Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00551)
MIC Name Enterococcus hirae (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus hirae
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Pathogen
Genome Size (bp) 2960055
No. of Coding Genes 2404
No. of Non-Coding Genes 54
No. of Small Non-Coding Genes 54
No. of Gene Transcripts 2458
No. of Base Pairs 2802314
Description Enterococcus hirae is a facultatively anaerobic, Gram positive species of Enterococcus. It is involved in growth depression in young chickens and endocarditis and sepsis in humans.
External Links Taxonomy ID
1354
Genome Assembly ID
INF_E1_1.0
GOLD Organism ID
Go0002089
Disease Relevance
          Infectious endocarditis  [ICD-11: BB40]
             Description Enterococcus hirae was associated with endocardial infection. [1]
          Sepsis  [ICD-11: 1G41]
             Description Enterococcus hirae can cause spontaneous bacterial peritonitis with sepsis. [2]
Host Immune Factors (HIFs)
          Programmed Cell Death 1 Protein
             HIF ID HIFM0191 HIF Info       Class Checkpoint molecule (CM)
             Description Enterococcus hirae could reverse resistance to PD-1 blockade. [3]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description IgG could response to Enterococcus hirae. [4]
          FOXP3+ regulatory T cells
             HIF ID HIFC0033 HIF Info       Class T cells (TCs)
             Description The CD8+ T cell-to-Foxp3+ regulatory T cell ratio was positively correlated with the proportions of Enterococcus hirae-reactive CD8+ T cells. [5]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Reactivity toward Enterococcus hirae demonstrated robust CD8+ T cell response. [5]
Environmental Factor(s)
             Disbiome ID
      796
             gutMDisorder ID
      gm0287
References
1 The application of the loop-mediated isothermal amplification (LAMP) method for diagnosing Enterococcus hirae-associated endocarditis outbreaks in chickens. BMC Microbiol. 2019 Feb 21;19(1):48. doi: 10.1186/s12866-019-1420-z.
2 Spontaneous bacterial peritonitis with sepsis caused by Enterococcus hirae. J Korean Med Sci. 2012 Dec;27(12):1598-600. doi: 10.3346/jkms.2012.27.12.1598. Epub 2012 Dec 7.
3 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.
4 Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota.Cell. 2018 Jun 14;173(7):1742-1754.e17. doi: 10.1016/j.cell.2018.05.008.
5 Reactivity toward Bifidobacterium longum and Enterococcus hirae demonstrate robust CD8(+) T cell response and better prognosis in HBV-related hepatocellular carcinoma. Exp Cell Res. 2017 Sep 15;358(2):352-359. doi: 10.1016/j.yexcr.2017.07.009. Epub 2017 Jul 8.

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