General Information of HIF (ID: HIFC0033)
HIF Name	FOXP3+ regulatory T cells
HIF Synonym(s)	FOXP3+, FOXP3+ Tregulatory cells
HIF Classification	T cells (TCs)
Description	FOXP3 + regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years.				[1]

Microbe Species (MIC) Regulated by This HIF
Akkermansia muciniphila (verrucomicrobia)			MIC00056
Description	Akkermansia muciniphila could increase adipose tissue-resident CD4+ Foxp3+ regulatory T cells.				[2]
Bacteroides caccae (CFB bacteria)			MIC00148
Description	Bacteroides caccae has been shown to induce the accumulation of FOXP3+ pTreg cells.				[3]
Bacteroides thetaiotaomicron (CFB bacteria)			MIC00179
Description	Bacteroides thetaiotaomicron has been shown to induce the accumulation of FOXP3+ pTreg cells.				[3]
Enterococcus hirae (firmicutes)			MIC00551
Description	The CD8+ T cell-to-Foxp3+ regulatory T cell ratio was positively correlated with the proportions of Enterococcus hirae-reactive CD8+ T cells.				[4]
Faecalibacterium prausnitzii (firmicutes)			MIC00590
Description	Faecalibacterium prausnitzii induced Foxp3+ Tregulatory cells to produce short-chain fatty acid butyrate.				[5]
Fusobacterium nucleatum (fusobacteria)			MIC00617
Description	High levels of infiltrating FOXP3+ cells have been associated with better patient prognosis in colorectal cancer with Fusobacterium nucleatum infection.				[6]

References
1	tTregs, pTregs, and iTregs: similarities and differences.Immunol Rev. 2014 May;259(1):88-102. doi: 10.1111/imr.12160.
2	Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function. PLoS One. 2017 Mar 1;12(3):e0173004. doi: 10.1371/journal.pone.0173004. eCollection 2017.
3	Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.
4	Reactivity toward Bifidobacterium longum and Enterococcus hirae demonstrate robust CD8(+) T cell response and better prognosis in HBV-related hepatocellular carcinoma. Exp Cell Res. 2017 Sep 15;358(2):352-359. doi: 10.1016/j.yexcr.2017.07.009. Epub 2017 Jul 8.
5	A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function.Gut Microbes. 2015 Jul 4;6(4):234-42. doi: 10.1080/19490976.2015.1056973.
6	Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J Gastroenterol. 2016 Jan 14;22(2):557-66. doi: 10.3748/wjg.v22.i2.557.

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