Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00617)
MIC Name Fusobacterium nucleatum (fusobacteria)
MIC Synonyms Bacillus fusiformis
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium nucleatum
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative; Proteolytic
Gram Negative
Host Relationship Commensal
Genome Size (bp) 2174500
No. of Coding Genes 2466
No. of Non-Coding Genes 16
No. of Small Non-Coding Genes 16
No. of Gene Transcripts 2482
No. of Base Pairs 2382847
Description Fusobacterium nucleatum is an obligate anaerobic, Gram negative oral bacterium that plays a role in periodontal disease. It is indigenous to the human oral cavity and is a key component of periodontal plaque. It has the ability to coaggregate with other bacteria species in the oral cavity.
External Links Taxonomy ID
851
Genome Assembly ID
ASM154643v1
GOLD Organism ID
Go0003582
Disease Relevance
          Colorectal cancer  [ICD-11: 2B91]
             Description Fusobacterium nucleatum was associated with colorectal cancer. [1]
          Crohn disease  [ICD-11: DD70]
             Description Lymph nodes contained great numbers of Fusobacteria in Crohn's disease. [2]
          Periodontal disease  [ICD-11: DA0C]
             Description Fusobacterium nucleatum is one of the most important types of microorganisms in the oral cavity in both healthy and non-healthy individuals, this Gram-negative pathogen is dominant in periodontal disease. [3]
          Sepsis  [ICD-11: 1G41]
             Description Fusobacteria was associated with septicaemia. [4]
Host Genetic Factors (HGFs)
          TLR4
             HGF ID HGF2320 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The overexpression of TLR4 displayed higher abundances of Fusobacteria. [5]
          hsa-miR-4802-5p
             HGF ID HGF0686 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-4802 expression can be downregulated by Fusobacterium nucleatum. [6]
          hsa-miR-515-5p
             HGF ID HGF0804 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The has-miR-515-5p could promote the growth of Fusobacterium nucleatum. [5]
          hsa-miR-135b-5p
             HGF ID HGF0264 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The abundance of Fusobacterium nucleatum can affect cytokine expression possibly via recognition by TLR4 and TLR2 with regulation by miR-135b. [7]
          hsa-miR-18a-5p
             HGF ID HGF0238 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-18a expression can be downregulated by Fusobacterium nucleatum. [6]
          hsa-miR-22-3p
             HGF ID HGF0197 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-22 was positively correlated with Fusobacterium nucleatum quantification in CRC tumours. [7]
          hsa-miR-28-5p
             HGF ID HGF0179 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-28-5p is significantly associated with levels of Fusobacterium nucleatum DNA (p-value<0.05). [7]
          hsa-miR-34a-5p
             HGF ID HGF0151 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The abundance of Fusobacterium nucleatum can affect cytokine expression possibly via recognition by TLR4 and TLR2 with regulation by miR-34a. [7]
          hsa-miR-21-3p
             HGF ID HGF0203 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The TLR4/MYD88/NF-B pathway is activated by Fusobacterium nucleatum infection, which stimulates the overexpression of miR-21. [7]
          hsa-miR-876-5p
             HGF ID HGF2514 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-876-5p expression could affect gene expression of the anaerobic species Fusobacterium nucleatum. [5]
          hsa-miR-325
             HGF ID HGF2515 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-325 expression could affect gene expression of the anaerobic species Fusobacterium nucleatum. [5]
          hsa-miR-1253
             HGF ID HGF2516 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1253 expression could affect gene expression of the anaerobic species Fusobacterium nucleatum. [5]
          has-miR-101
             HGF ID HGF2673 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The has-miR-101 could affect gene expression of the anaerobic species Fusobacterium nucleatum. [5]
          hsa-miR-515-5p
             HGF ID HGF0804 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-515-5p could affect gene expression of the anaerobic species Fusobacterium nucleatum. [5]
          rs1057028
             HGF ID HGF1735 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The haplotype block rs1057028 was significantly associated with pathogens Fusobacterium nucleatum (p0.05). [8]
          rs516246
             HGF ID HGF1582 HGF Info       Class Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
             Description The rs516246 SNP was significantly associated with the abundance of Fusobacteria (p-value=0.00731). [9]
Host Immune Factors (HIFs)
          Retinoic acid receptor responder protein2
             HIF ID HIFM0196 HIF Info       Class Antimicrobial peptide (AMP)
             Description Fusobacterium nucleatum is sensitive to chemerin. [10]
          CEA cell adhesion molecule 1
             HIF ID HIFM0057 HIF Info       Class Checkpoint molecule (CM)
             Description Fusobacterium nucleatum has a strong enzymatic activity which can bind and activates CEACAM1 leading to the inhibition of immune cell activities. [11]
          Indoleamine 2,3-dioxygenase 1
             HIF ID HIFM0120 HIF Info       Class Checkpoint molecule (CM)
             Description IDO1-induced low Trp and high Kyn environment inhibited the intracellular multiplication of Fusobacterium nucleatum (Fn) in dTHP1 cells. [12]
          T-cell immunoreceptor with Ig and ITIM domains
             HIF ID HIFM0214 HIF Info       Class Checkpoint molecule (CM)
             Description The colon cancer-associated bacterium Fusobacterium nucleatum may directly inhibit antitumor immunity by engaging TIGIT. [13]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Patent neutrophils present a primed phenotype when challenged ex vivo with Fusobacterium nucleatum. [14]
          M1 macrophages
             HIF ID HIFC0019 HIF Info       Class Macrophages (Mac)
             Description Fusobacteria nucleatum AI-2 enhanced M1 polarization of macrophages, possibly through TNFSF9/TRAF1/p-AKT/IL-1signaling. [15]
          CD68+ macrophages
             HIF ID HIFC0021 HIF Info       Class Macrophages (Mac)
             Description The high abundance of Fusobacterium nucleatum was positively correlated with a high density of CD68+ macrophages(79%;p=0.019). [16]
          FOXP3+ regulatory T cells
             HIF ID HIFC0033 HIF Info       Class T cells (TCs)
             Description High levels of infiltrating FOXP3+ cells have been associated with better patient prognosis in colorectal cancer with Fusobacterium nucleatum infection. [1]
          CD3+ T cells
             HIF ID HIFC0064 HIF Info       Class T cells (TCs)
             Description High levels of infiltrating CD3+ cells have been associated with better patient prognosis in colorectal cancer with Fusobacterium nucleatum infection. [1]
          CD45RO+ T cells
             HIF ID HIFC0070 HIF Info       Class T cells (TCs)
             Description High levels of infiltrating CD45RO+ T cells have been associated with better patient prognosis in colorectal cancer with Fusobacterium nucleatum infection. [1]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description High levels of infiltrating CD8+ cells have been associated with better patient prognosis in colorectal cancer with Fusobacterium nucleatum infection. [1]
Environmental Factor(s)
             Disbiome ID
      305
             gutMDisorder ID
      gm0344
             aBiofilm Organism
      Fusobacterium nucleatum
References
1 Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J Gastroenterol. 2016 Jan 14;22(2):557-66. doi: 10.3748/wjg.v22.i2.557.
2 The Human Mesenteric Lymph Node Microbiome Differentiates Between Crohn's Disease and Ulcerative Colitis. J Crohns Colitis. 2019 Jan 1;13(1):58-66. doi: 10.1093/ecco-jcc/jjy136.
3 Determination of the Role of Fusobacterium Nucleatum in the Pathogenesis in and Out the Mouth. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2020 Jun 1;41(1):87-99. doi: 10.2478/prilozi-2020-0026.
4 IgA and FcRI: Pathological Roles and Therapeutic Opportunities. Front Immunol. 2019 Mar 22;10:553. doi: 10.3389/fimmu.2019.00553. eCollection 2019.
5 Current understanding of the gut microbiota shaping mechanisms.J Biomed Sci. 2019 Aug 21;26(1):59. doi: 10.1186/s12929-019-0554-5.
6 Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development. Genome Med. 2019 Feb 25;11(1):11. doi: 10.1186/s13073-019-0621-2.
7 Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis. World J Gastroenterol. 2018 Dec 21;24(47):5351-5365. doi: 10.3748/wjg.v24.i47.5351.
8 Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease.J Periodontol. 2017 Jul;88(7):663-672. doi: 10.1902/jop.2017.160553. Epub 2017 Apr 7.
9 FUT2 genotype and secretory status are not associated with fecal microbial composition and inferred function in healthy subjects.Gut Microbes. 2018 Jul 4;9(4):357-368. doi: 10.1080/19490976.2018.1445956. Epub 2018 Apr 27.
10 Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease.Front Immunol. 2017 Mar 29;8:353. doi: 10.3389/fimmu.2017.00353. eCollection 2017.
11 Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1.Oncoimmunology. 2019 Mar 27;8(6):e1581531. doi: 10.1080/2162402X.2019.1581531. eCollection 2019.
12 Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications.J Cancer. 2019 Jun 2;10(12):2771-2782. doi: 10.7150/jca.31727. eCollection 2019.
13 Cancer and the microbiota.Science. 2015 Apr 3;348(6230):80-6. doi: 10.1126/science.aaa4972.
14 Human neutrophils and oral microbiota: a constant tug-of-war between a harmonious and a discordant coexistence.Immunol Rev. 2016 Sep;273(1):282-98. doi: 10.1111/imr.12451.
15 Autoinducer-2 of Fusobacterium nucleatum promotes macrophage M1 polarization via TNFSF9/IL-1 signaling.Int Immunopharmacol. 2019 Sep;74:105724. doi: 10.1016/j.intimp.2019.105724. Epub 2019 Jul 1.
16 Intratumoral Fusobacterium nucleatum abundance correlates with macrophage infiltration and CDKN2A methylation in microsatellite-unstable colorectal carcinoma.Virchows Arch. 2017 Sep;471(3):329-336. doi: 10.1007/s00428-017-2171-6. Epub 2017 Jun 8.

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