Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0120)
HIF Name
Indoleamine 2,3-dioxygenase 1
HIF Synonym(s)
Indoleamine-pyrrole 2,3-dioxygenase, IDO-1, IDO1, ID, INDO
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Dioxygenase; Oxidoreductase
Description IDO1 is reported to be crucial immune modulator. [1]
Pfam Indoleamine 2,3-dioxygenase (PF01231 )
Pathway African trypanosomiasis (hsa05143 )
Metabolic pathways (hsa01100 )
Tryptophan metabolism (hsa00380 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
I23O1_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description Indoleamine 2,3-dioxygenase (IDO) promotes uropathogenic Escherichia coli (UPEC) colonization of bladder in murine cystitis and survival of extracellular bacteria. [2]
         Fusobacterium nucleatum (fusobacteria) MIC00617
             Description IDO1-induced low Trp and high Kyn environment inhibited the intracellular multiplication of Fusobacterium nucleatum (Fn) in dTHP1 cells. [3]
         Lactobacillus reuteri (firmicutes) MIC00731
             Description Lactobacillus reuteri has been described to reduce despair like behavior in mice by inhibiting elevated levels of IDO and reducing peripheral levels of kynurenine. [4]
         Lactobacillus sp. (firmicutes) MIC00701
             Description The Lactobacillus species could inhibit the expression of mammalian IDO1. [5]
         Mycobacterium leprae (actinobacteria) MIC00851
             Description Induction of IDO in T cells and dendritic cells by Mycobacterium leprae. [2]
         Streptococcus pneumoniae (firmicutes) MIC01263
             Description The host tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase 1(IDO1), is induced specifically in the lungs of mice infected with Streptococcus pneumoniae. [6]
References
1 Exploration of a novel prognostic risk signatures and immune checkpoint molecules in endometrial carcinoma microenvironment.Genomics. 2020 Sep;112(5):3117-3134. doi: 10.1016/j.ygeno.2020.05.022. Epub 2020 May 29.
2 Induction of indoleamine 2,3-dioxygenase by uropathogenic bacteria attenuates innate responses to epithelial infection.J Infect Dis. 2012 Jun 15;205(12):1830-9. doi: 10.1093/infdis/jis280. Epub 2012 Apr 3.
3 Role of IDO and TDO in Cancers and Related Diseases and the Therapeutic Implications.J Cancer. 2019 Jun 2;10(12):2771-2782. doi: 10.7150/jca.31727. eCollection 2019.
4 Role of Microbiota and Tryptophan Metabolites in the Remote Effect of Intestinal Inflammation on Brain and Depression.Pharmaceuticals (Basel). 2018 Jun 25;11(3):63. doi: 10.3390/ph11030063.
5 Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques.Cell Rep. 2015 Nov 24;13(8):1589-97. doi: 10.1016/j.celrep.2015.10.026. Epub 2015 Nov 12.
6 Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs.Infect Immun. 2010 Jun;78(6):2723-33. doi: 10.1128/IAI.00008-10. Epub 2010 Apr 12.

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