Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00701)
MIC Name Lactobacillus sp. (firmicutes)
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus sp.
Oxygen Sensitivity Facultative anaerobe; Microaerophile
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Probiotic
Description Lactobacillus is a genus of Gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria. They are a major part of the lactic acid bacteria group. In humans, they constitute a significant component of the microbiota at a number of body sites, such as the digestive system, urinary system, and genital system. In women of European ancestry, Lactobacillus species are normally a major part of the vaginal microbiota.
External Links Taxonomy ID
1591
GOLD Organism ID
Go0546899
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Lactobacillus was reported to be present in higher concentrations in children with Autism Spectrum Disorder. [1]
          Autoimmune liver disease  [ICD-11: DB96]
             Description Lactobacillus was associated with PSC-IBD(primary sclerosing cholangitis-inflammatory bowel disease), but not with isolated PSC. [2]
          Behcet disease  [ICD-11: 4A62]
             Description The abundance of Lactobacillaceae increased significantly in patients with Behcet's disease. [3]
          Chronic kidney disease  [ICD-11: GB61]
             Description Lactobacillaceae decreased in uremia subjects. [4]
          Colon cancer  [ICD-11: 2B90]
             Description Lactobacillus is downregulated in expression of Colon cancer. [5]
          Crohn disease  [ICD-11: DD70]
             Description Lactobacillus were enriched in Crohns disease. [6]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description The feces of patients with irritable bowel syndrome had lower numbers of Lactobacillus compared with controls. [7]
          Obesity  [ICD-11: 5B81]
             Description Lactobacillus is upregulated in disease expression of obesity. [8]
          Rheumatoid arthritis  [ICD-11: FA20]
             Description Lactobacillus was associated with genetic variants in Rheumatoid Arthritis. [9]
          Schizophrenia  [ICD-11: 6A20]
             Description Lactobacillus was relatively more abundant in schizophrenia which had been shown to modulate chronic inflammation. [10]
          Ulcerative colitis  [ICD-11: DD71]
             Description Lactobacillus was associated with PSC-IBD(primary sclerosing cholangitis -inflammatory bowel disease), but not with isolated PSC. [2]
Host Genetic Factors (HGFs)
          15q11-13
             HGF ID HGF2318 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The duplicaton of 15q is assciated with the reduction of the relative abundance of Lactobacillus caused by ampicillin (p-value<0.05). [11]
          SIRT1
             HGF ID HGF2327 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of SIRT1 could significantly decrease relative abundances of Lactobacillus. (p-value<0.05) [12]
          MUC2
             HGF ID HGF2331 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MUC2 showed decreased abundance of Lactobacilli. [13]
          ARNTL
             HGF ID HGF2325 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of BMAL1 could decrease relative abundances of Lactobacillaceae spp. (p-value<0.0001). [14]
          AVP
             HGF ID HGF2328 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of AVP could significantly increase relative abundances of Lactobacillaceae spp. (p-value<0.05). [15]
          SLC15A1
             HGF ID HGF2354 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of PepT1 could decrease the abundance of Lactobacillus. [16]
          rs921312
             HGF ID HGF2072 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs921312 SNP was significantly associated with the abundance of Lactobacillus (p-value=3.67E-07). [17]
          rs76906435
             HGF ID HGF2176 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs76906435 SNP was significantly associated with the relative abundance of Lactobacillus (p-value=2.58E-09). [18]
          rs7604649
             HGF ID HGF1559 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7604649 SNP was significantly associated with the abundance of Lactobacillus (p-value=1.73E-05). [17]
          rs6761743
             HGF ID HGF1561 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6761743 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs6547547
             HGF ID HGF1560 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6547547 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs6547544
             HGF ID HGF1562 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6547544 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs651821
             HGF ID HGF1924 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The APOA5 rs651821 SNP increased the abundance of Lactobacillus. [19]
          rs448261
             HGF ID HGF2071 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs448261 SNP was significantly associated with the abundance of Lactobacillus (p-value=3.67E-07). [17]
          rs443233
             HGF ID HGF2069 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs443233 SNP was significantly associated with the abundance of Lactobacillus (p-value=3.67E-07). [17]
          rs4142162
             HGF ID HGF2212 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs4142162 SNP in mucosal immunity pathways influences the abundance of Lactobacillus in the upper airway (p-value=1.45E-07). [20]
          rs374816
             HGF ID HGF2070 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs374816 SNP was significantly associated with the abundance of Lactobacillus (p-value=3.67E-07). [17]
          rs2886029
             HGF ID HGF1568 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2886029 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.31E-05). [17]
          rs2702164
             HGF ID HGF1662 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2702164 SNP was significantly associated with the abundance of Lactobacillus (p-value=8.02E-06). [17]
          rs2702158
             HGF ID HGF1660 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2702158 SNP was significantly associated with the abundance of Lactobacillus (p-value=1.40E-05). [17]
          rs2364267
             HGF ID HGF1563 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2364267 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs2124177
             HGF ID HGF1557 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2124177 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs2061080
             HGF ID HGF1555 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2061080 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs17697515
             HGF ID HGF1589 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17697515 SNP was significantly associated with the abundance of Lactobacillus (p-value=1.71E-05). [17]
          rs1733329
             HGF ID HGF1661 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1733329 SNP was significantly associated with the abundance of Lactobacillus (p-value=1.40E-05). [17]
          rs12714120
             HGF ID HGF1564 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12714120 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs11686691
             HGF ID HGF1556 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11686691 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs11126954
             HGF ID HGF1565 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11126954 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs11126953
             HGF ID HGF1566 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11126953 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs10865473
             HGF ID HGF1567 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10865473 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs1031532
             HGF ID HGF1558 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1031532 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs10180739
             HGF ID HGF1569 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10180739 SNP was significantly associated with the abundance of Lactobacillus (p-value=2.34E-05). [17]
          rs7113056
             HGF ID HGF1514 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7113056 SNP was significantly associated with the abundance of Lactobacillales (p-value=1.72E-13). [21]
          rs7083345
             HGF ID HGF1602 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7083345 SNP was significantly associated with the abundance of Lactobacillales (p-value=2.89E-9). [21]
          rs62295801
             HGF ID HGF1614 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs62295801 SNP was significantly associated with the abundance of Lactobacillales (p-value=5.32E-10). [21]
          rs59042687
             HGF ID HGF2083 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs59042687 SNP was significantly associated with the abundance of Lactobacillales (p-value=6.22E-9). [21]
          rs1362404
             HGF ID HGF2183 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1362404 SNP was significantly associated with the abundance of Lactobacillales (p-value=1.56E-8). [21]
          rs10928827
             HGF ID HGF2141 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10928827 SNP was significantly associated with the abundance of Lactobacillales (p-value=4.19E-9). [21]
          rs2413583
             HGF ID HGF2559 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2413583 SNP is associated with the abundance of Lactobacillus. [22]
          rs13204742
             HGF ID HGF2560 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs13204742 SNP is associated with the abundance of Lactobacillus. [22]
          rs6651252
             HGF ID HGF2561 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6651252 SNP is associated with the abundance of Lactobacillus. [22]
          rs6740462
             HGF ID HGF2537 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6740462 SNP is associated with the abundance of Lactobacillus. [22]
          rs16967103
             HGF ID HGF2562 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs16967103 SNP is associated with the abundance of Lactobacillus. [22]
          rs4743820
             HGF ID HGF2563 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4743820 SNP is associated with the abundance of Lactobacillus. [22]
          rs1801274
             HGF ID HGF2564 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-MV)
             Description The rs1801274 SNP is associated with the abundance of Lactobacillus. [22]
          rs1250546
             HGF ID HGF2565 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1250546 SNP is associated with the abundance of Lactobacillus. [22]
          rs6708413
             HGF ID HGF2544 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6708413 SNP is associated with the abundance of Lactobacillus. [22]
          rs12778642
             HGF ID HGF2566 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs12778642 SNP is associated with the abundance of Lactobacillus. [22]
          rs1819333
             HGF ID HGF2529 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1819333 SNP is associated with the abundance of Lactobacillus. [22]
          rs1292053
             HGF ID HGF2567 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-MV)
             Description The rs1292053 SNP is associated with the abundance of Lactobacillus. [22]
          rs6087990
             HGF ID HGF2568 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-UV)
             Description The rs6087990 SNP is associated with the abundance of Lactobacillus. [22]
Host Immune Factors (HIFs)
          C-C motif chemokine 13
             HIF ID HIFM0018 HIF Info       Class Antimicrobial peptide (AMP)
             Description The CCL13 expression was upregulated by Lactobacillus. [23]
          Melanocyte-stimulating hormone alpha
             HIF ID HIFM0064 HIF Info       Class Antimicrobial peptide (AMP)
             Description Lactobacillus-based probiotics can be useful for modulation of the production of Alpha-MSH autoAbs due to their Clp proteins sequence homology with the C-terminal of -MSH. [24]
          Human beta defensin 2
             HIF ID HIFM0092 HIF Info       Class Antimicrobial peptide (AMP)
             Description Lactobacillus strains are able to induce secretion of hBD-2 from enterocytes. [25]
          Regenerating islet-derived protein 3-gamma
             HIF ID HIFM0198 HIF Info       Class Antimicrobial peptide (AMP)
             Description The increasing probiotic Lactobacilli can restore the properties of RegIII gamma. [26]
          Human lactoferricin
             HIF ID HIFM0237 HIF Info       Class Antimicrobial peptide (AMP)
             Description A positive correlation between the fecal Lactobacillus amount and lactoferrin has previously been reported in 3-day old infants. [27]
          HD-5(1-9)
             HIF ID HIFM0289 HIF Info       Class Antimicrobial peptide (AMP)
             Description HD-519 treatment could decrease Lactobacillus. [28]
          Rantes
             HIF ID HIFM0323 HIF Info       Class Antimicrobial peptide (AMP)
             Description A reduced relative abundance of Lactobacillus causes increased production of several inflammatory cytokines RANTES. [29]
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description Lactobacillus species were insufficient to ameliorate DSS colitis once gut B cells were reduced below a certain threshold. [30]
          CD40 ligand
             HIF ID HIFM0051 HIF Info       Class Checkpoint molecule (CM)
             Description T helper cells up-regulates CD154 when stimulated with antigens from Lactobacillus. [31]
          Indoleamine 2,3-dioxygenase 1
             HIF ID HIFM0120 HIF Info       Class Checkpoint molecule (CM)
             Description The Lactobacillus species could inhibit the expression of mammalian IDO1. [32]
          Tumor necrosis factor ligand superfamily member 15
             HIF ID HIFM0224 HIF Info       Class Checkpoint molecule (CM)
             Description The deletion of TL1A could reduce the abundance of Lactobacillus. [33]
          Interferon-22
             HIF ID HIFM0143 HIF Info       Class Cytokine (Cyt)
             Description Lactobacilli produce an AhR ligand,which induces IL22 expression. [34]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillaceae was negatively correlated with IL-6 expression. [35]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Lactobacillus can activate Syk in dendritic cells. [36]
          Bone marrow-derived dendritic cells
             HIF ID HIFC0166 HIF Info       Class Dendritic cells (DCs)
             Description Lactobacilli is able to induce autophagy activation in bone marrow-derived dendritic cells. [37]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Lactobacillus was selectively IgA+ (High IgA binding) coated in patients with inflammatory bowel disease (Crohn disease and ulcerative colitis). [38]
          CD16+ Natural Killer cells
             HIF ID HIFC0094 HIF Info       Class Natural killer cells (NKCs)
             Description The increased proportion of CD16+ NK cells was associated with the decrease of gut commensal bacteria(Lactobacillus). [39]
          Regulatory T cells
             HIF ID HIFC0030 HIF Info       Class T cells (TCs)
             Description Treg cells are thymic Treg cells that can recognize bacterial antigens from Lactobacillus. [34]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description Higher proportions of gut Lactobacillales were associated with higher CD4 T cells in the gut during antiretroviral therapy. [40]
          T-cell surface glycoprotein CD4
             HIF ID HIFM0050 HIF Info       Class T-cell receptor (TCR)
             Description HIV-pneumonia patients with low CD4 counts exhibited enrichment of specific Lactobacillales(false discovery rate q < 0.05, read difference 100 reads, and presence in 50%). [41]
Environmental Factor(s)
             Disbiome ID
      1
             gutMDisorder ID
      gm0393
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