Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0198)
HIF Name
Regenerating islet-derived protein 3-gamma
HIF Synonym(s)
REG3-gama, REG3G
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antimicrobial
Description Regenerating islet-derived protein 3-gamma has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Lectin C-type domain (PF00059 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
REG3G_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Akkermansia muciniphila (verrucomicrobia) MIC00056
             Description Akkermansia muciniphila transfer increased expression of antimicrobial peptide REGIII gamma. [2]
         Bacteroides thetaiotaomicron (CFB bacteria) MIC00179
             Description Monocolonization of germ-free mice with Gram-negative Bacteroides thetaiotaomicron resulted in a modest upregulation of RegIII gamma(2.5-fold). [3]
         Bifidobacterium breve (actinobacteria) MIC00210
             Description The phenotype was reversed by colonization of the mice with altered Bifidobacterium breve and normalized RegIII expression levels. [4]
         Bifidobacterium sp. (actinobacteria) MIC00224
             Description The increasing probiotic Bifidobacteria can restore the properties of RegIII gamma. [5]
         Citrobacter rodentium (enterobacteria) MIC00366
             Description It was described that microbiota transplantation from resistant to susceptible wild-type mice before Citrobacter rodentium infection caused delayed pathogen colonization and mortality due to IL-22 mediated production of RegIII. [4]
         Enterococcus faecalis (firmicutes) MIC00548
             Description RegIII gamma promoted protection against vancomycin resistant Enterococcus faecalis(enzymatic activity). [6]
         Enterococcus sp. (firmicutes) MIC00552
             Description The upregulated RegIII level providing increased resistance to vancomycin-resistant Enterococcus (VRE). [3]
         Lactobacillus sp. (firmicutes) MIC00701
             Description The increasing probiotic Lactobacilli can restore the properties of RegIII gamma. [5]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Innate upregulation of RegIII gamma in intestinal epithelium conferred protection against Listeria monocytogenes infection. [3]
         Listeria welshimeri (firmicutes) MIC00773
             Description RegIII gamma killed Gram+ bacteria(enzymatic activity)and protected against mucosal Listeria infections. [7]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description RegIII gamma showed little regulatory affinity binding to preparations of Pseudomonas aeruginosa compare with the positive bacteria(p<0.05). [8]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description RegIII gamma showed little regulatory affinity binding to preparations of Salmonella typhimurium compare with the positive bacteria(p<0.05). [8]
         Salmonella sp. (enterobacteria) MIC01149
             Description RegIII gamma expression was markedly increased in a model of Salmonella colitis. [4]
References
1 Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950.Appl Environ Microbiol. 2013 Dec;79(24):7745-54. doi: 10.1128/AEM.02470-13. Epub 2013 Oct 4.
2 Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice. Gut. 2018 Aug;67(8):1445-1453. doi: 10.1136/gutjnl-2017-314508. Epub 2017 Dec 21.
3 The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria.Front Immunol. 2020 May 20;11:965. doi: 10.3389/fimmu.2020.00965. eCollection 2020.
4 Intestinal antimicrobial peptides during homeostasis, infection, and disease.Front Immunol. 2012 Oct 9;3:310. doi: 10.3389/fimmu.2012.00310. eCollection 2012.
5 Leaky Gut As a Danger Signal for Autoimmune Diseases.Front Immunol. 2017 May 23;8:598. doi: 10.3389/fimmu.2017.00598. eCollection 2017.
6 Role of the microbiota in immunity and inflammation.Cell. 2014 Mar 27;157(1):121-41. doi: 10.1016/j.cell.2014.03.011.
7 Salmonella-induced mucosal lectin RegIII kills competing gut microbiota.PLoS One. 2011;6(6):e20749. doi: 10.1371/journal.pone.0020749. Epub 2011 Jun 9.
8 Symbiotic bacteria direct expression of an intestinal bactericidal lectin.Science. 2006 Aug 25;313(5790):1126-30. doi: 10.1126/science.1127119.

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