Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01054)
MIC Name Pseudomonas aeruginosa (gamma-proteobacteria)
MIC Synonyms Bacterium aeruginosum
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas aeruginosa
Oxygen Sensitivity Aerobe
Microbial Metabolism Strictly respiratory; Utilize amino acids,carbohydrates and fatty acids
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 6829406
No. of Coding Genes 5718
No. of Non-Coding Genes 68
No. of Small Non-Coding Genes 68
No. of Gene Transcripts 5786
No. of Base Pairs 6341502
Description Pseudomonas aeruginosa is a Gram-negative, rod-shaped, asporogenous, and monoflagellated bacterium that has an incredible nutritional versatility. It has been found in environments such as soil, water, humans, animals, plants, sewage and hospitals. It is known to cause chronic respiratory disease.
External Links Taxonomy ID
287
Genome Assembly ID
PUPa3_1.0
GOLD Organism ID
Go0005309
Disease Relevance
          Chronic obstructive pulmonary disease  [ICD-11: CA22]
             Description Pseudomonas aeruginosa outgrowth was associated with chronic respiratory disease. [1]
          Cystic fibrosis  [ICD-11: CA25]
             Description Pseudomonas aeruginosa is an opportunistic pathogen that commonly infects the Cystic fibrosis lung, promoting an accelerated decline of pulmonary function. [2]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Pseudomonas aeruginosa significantly increased in irritable bowel syndrome patients. [3]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Pseudomonas aeruginosa was associated with type 2 diabetes. [4]
Host Genetic Factors (HGFs)
          hsa-miR-182-5p
             HGF ID HGF0234 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-182-5p expression showed significantly upregulated upon Staphylococcus aureus infection (p-value<0.05). [5]
          hsa-miR-26a-5p
             HGF ID HGF0185 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-26a-5p expression showed significantly downregulated upon Pseudomonas aeruginosa infection (p-value<0.05). [5]
          WFDC21P
             HGF ID HGF0970 HGF Info       Class Non-coding RNA: Pseudogene (ncRNA-PDG)
             Description The differentially expressed lncRNA WFDC21P might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          hsa-miR-1247-5p
             HGF ID HGF0281 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-1207 expression was upregulated 2-fold by Pseudomonas aeruginosa antigens. [7]
          CMB9-55F22.1
             HGF ID HGF1088 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA CMB9-55F22.1 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          LINC02551
             HGF ID HGF0908 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA LINC02551 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          LINC01138
             HGF ID HGF0873 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA RP11-495P10.8 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          POLR2J4
             HGF ID HGF0810 HGF Info       Class Non-coding RNA: Pseudogene (ncRNA-PDG)
             Description The differentially expressed lncRNA POLR2J4 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          mmu-miR-453
             HGF ID HGF0807 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-667 expression showed 1.20-fold up-regulation by Pseudomonas aeruginosa infection. [8]
          hsa-miR-762
             HGF ID HGF0697 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-762 expression was 2-fold upregulation by Pseudomonas aeruginosa antigens. [7]
          LINC00992
             HGF ID HGF0618 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA LINC00992 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          LINC00862
             HGF ID HGF0610 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA LINC00862 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          MANCR
             HGF ID HGF0609 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA LINC00704 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          hsa-miR-449c
             HGF ID HGF0584 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-449c was differentially expressed in the positive and negative groups of Pseudomonas aeruginosa (p-value<0.01). [9]
          hsa-miR-432-5p
             HGF ID HGF0583 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-432-5p was differentially expressed in the positive and negative groups of Pseudomonas aeruginosa (p-value<0.01). [9]
          hsa-miR-3170
             HGF ID HGF0582 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-3170 was differentially expressed in the positive and negative groups of Pseudomonas aeruginosa (p-value<0.01). [9]
          hsa-miR-1276
             HGF ID HGF0581 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-1276 was differentially expressed in the positive and negative groups of Pseudomonas aeruginosa (p-value<0.01). [9]
          LINC02560
             HGF ID HGF0446 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA LINC02560 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          DDIT4-AS1
             HGF ID HGF0308 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA RP11-442H21.2 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          hsa-let-7b-5p
             HGF ID HGF0300 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of let-7b expression was down-regulated 2-fold by Pseudomonas aeruginosa antigens. [7]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The negative feedback miRNAs, such as miR-155, whose levels are enhanced upon Pseudomonas aeruginosa infection to downregulate levels of immune response genes. [10]
          hsa-miR-200c-3p
             HGF ID HGF0210 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-200c-3p expression was significantly upregulated upon Pseudomonas aeruginosa infection (p-value<0.05). [5]
          hsa-miR-302b-3p
             HGF ID HGF0171 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-302b-3p expression was significantly upregulated upon Pseudomonas aeruginosa infection (p-value<0.05). [5]
          hsa-miR-495-3p
             HGF ID HGF0121 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-495-3p expression was significantly upregulated upon Pseudomonas aeruginosa infection (p-value<0.05). [5]
          hsa-miR-548a-3p
             HGF ID HGF0106 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-548 was differentially expressed in the positive and negative groups of Pseudomonas aeruginosa (p-value<0.01). [9]
          hsa-miR-92a-3p
             HGF ID HGF0089 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-92 expression was down-regulated 2-fold by Pseudomonas aeruginosa antigens. [7]
          LINC02561
             HGF ID HGF0068 HGF Info       Class Non-coding RNA: Long Non-coding (ncRNA-lncRNA)
             Description The differentially expressed lncRNA RP11-445P17.8 might be associated with Pseudomonas aeruginosa infection (p-value<0.05). [6]
          mmu-miR-294-3p
             HGF ID HGF0028 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-294-3p was significantly down-regulated by Pseudomonas aeruginosa antigens (p-value<0.05). [5]
          mmu-miR-669k-3p
             HGF ID HGF0017 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of miR-669k-3p was significantly down-regulated by Pseudomonas aeruginosa antigens (p-value<0.05). [5]
          hsa-miR-106b-5p
             HGF ID HGF0287 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Biofilm featuring presence of Pseudomonas demonstrated additive effect in inducing miR-106b. [11]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description Pseudomonas aeruginosa infection was negatively associated with abundance of monocytes and the presence of hsa-miR-146a. [12]
          rs1800797
             HGF ID HGF1722 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1800797 SNP was significantly associated with the abundance of Pseudomonas aeruginosa (p-value<0.05). [13]
          rs1800795
             HGF ID HGF1720 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1800795 SNP was significantly associated with the abundance of Pseudomonas aeruginosa (p-value<0.05). [13]
Host Immune Factors (HIFs)
          C-X-C motif chemokine 14
             HIF ID HIFM0077 HIF Info       Class Antimicrobial peptide (AMP)
             Description A concentration of 1M CXCL14 induced >99% killing of Pseudomonas aeruginosa PAO1. [14]
          Human beta defensin 3
             HIF ID HIFM0079 HIF Info       Class Antimicrobial peptide (AMP)
             Description HBD-3 of 8g/ml against Pseudomonas aeruginosa nosocomial strains bactericidal activity with defined resistance phenotypes such as amoxycillin. [15]
          Human beta defensin 4
             HIF ID HIFM0080 HIF Info       Class Antimicrobial peptide (AMP)
             Description HBD-4 is bactericidal against Pseudomonas aeruginosa. [16]
          Human beta defensin 2
             HIF ID HIFM0092 HIF Info       Class Antimicrobial peptide (AMP)
             Description HBD-2 has 21.4% effective for against Pseudomonas aeruginosa. [16]
          Human granulysin
             HIF ID HIFM0108 HIF Info       Class Antimicrobial peptide (AMP)
             Description Granulysin has effect on multidrug-resistant strains of Pseudomonas aeruginosa. [17]
          Interleukin 26
             HIF ID HIFM0146 HIF Info       Class Antimicrobial peptide (AMP)
             Description The recombinant human (rh) IL-26 inhibited the growth of gram-negative bacteria, such as Pseudomonas aeruginosa by direct bactericidal action and the median minimum inhibitory concentration values were in the range of 8.6 to 18.6 M. [18]
          Regenerating islet-derived protein 3-gamma
             HIF ID HIFM0198 HIF Info       Class Antimicrobial peptide (AMP)
             Description RegIII gamma showed little regulatory affinity binding to preparations of Pseudomonas aeruginosa compare with the positive bacteria(p<0.05). [19]
          Ribonuclease 8
             HIF ID HIFM0202 HIF Info       Class Antimicrobial peptide (AMP)
             Description RNase 8 had no significant antimicrobial activity against Pseudomonas aeruginosa(p>0.05)at the cefotaxime (30 g), ceftazidime (30 g), cefoperazone (75 g),and ceftriaxone (30 g) on MH agar. [20]
          Human calcitermin
             HIF ID HIFM0206 HIF Info       Class Antimicrobial peptide (AMP)
             Description The concentration of Calcitermin(50ug/ml) was active against Pseudomonas aeruginosa. [21]
          Human neutrophil peptide-1
             HIF ID HIFM0305 HIF Info       Class Antimicrobial peptide (AMP)
             Description Human neutrophil peptide-1(HNP-1) could kill the enzymatic activity of Pseudomonas aeruginosa. [22]
          KDAMP 19-mer
             HIF ID HIFM0311 HIF Info       Class Antimicrobial peptide (AMP)
             Description 19-mer KDAMP could kill the enzymatic activity of Pseudomonas aeruginosa. [23]
          Semenogelin I-derived AMP 29-residues, human
             HIF ID HIFM0326 HIF Info       Class Antimicrobial peptide (AMP)
             Description SgI-29 has a defense against Pseudomonas aeruginosa. [24]
          secreted type IIA Phospholipase A2
             HIF ID HIFM0329 HIF Info       Class Antimicrobial peptide (AMP)
             Description Pseudomonas aeruginosa laboratory strains and isolates could induce sPLA2-IIA expression. [25]
          Thrombin-derived C-terminal Peptide
             HIF ID HIFM0330 HIF Info       Class Antimicrobial peptide (AMP)
             Description Pseudomonas aeruginosa elastase cleaves thrombin is associated with the formation of a 21 amino acid TCP. [26]
          Ubiquicidin
             HIF ID HIFM0333 HIF Info       Class Antimicrobial peptide (AMP)
             Description Synthesized ubiquicidin (UBI)-loaded micelle to combat Pseudomonas aeruginosa in vitro and in vivo. [27]
          Human beta-defensin-28
             HIF ID HIFM0338 HIF Info       Class Antimicrobial peptide (AMP)
             Description Human HBD-28 variant against pathogenic bacteria Pseudomonas aeruginosa. [28]
          T cell immunoglobulin 3
             HIF ID HIFM0110 HIF Info       Class Checkpoint molecule (CM)
             Description The TIM-3 expression on neutrophils has enzymatic activity directly involved in a killing mechanism specific for Pseudomonas aeruginosa. [29]
          C-X-C motif chemokine 10
             HIF ID HIFM0074 HIF Info       Class Cytokine (Cyt)
             Description Pseudomonas aeruginosa keratitis identified CXCL10 as a major chemokine induced by Pseudomonas aeruginosa infection. [30]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Neutrophils has killed or inactivated activity against Pseudomonas aeruginosa. [31]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description IgM leads to protection against bacterial infection of Pseudomonas aeruginosa. [32]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model. [33]
          Immunoglobulin D
             HIF ID HIFM0277 HIF Info       Class Immunoglobulin (Ig)
             Description elevated IgD levels is associated with Pseudomonas aeruginosa infection. [34]
          CD56+ Natural Killer cells
             HIF ID HIFC0095 HIF Info       Class Natural killer cells (NKCs)
             Description The NKp44, of which the induction involved mainly CD56+ NK cells, was able to bind the Mycobacterium Pseudomonas aeruginosa. [35]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description A kill or inactivate but metabolically active Pseudomonas aeruginosa(deactivate enzymatic activity)could elicit Th1 pathways of cell-mediated immune responses. [36]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description A kill or inactivate but metabolically active Pseudomonas aeruginosa(deactivate enzymatic activity) could elicit Th17 pathways of cell-mediated immune responses. [36]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description A kill or inactivate but metabolically active Pseudomonas aeruginosa(deactivate enzymatic activity) could elicit Th2 pathways of cell-mediated immune responses. [36]
Environmental Factor(s)
             Disbiome ID
      37
             gutMDisorder ID
      gm0551
             aBiofilm Organism
      Pseudomonas aeruginosa
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