Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0074)
HIF Name
C-X-C motif chemokine 10
HIF Synonym(s)
C-X-C motif chemokine ligand 10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Hepatitis C and Endotheliitis. Among its related pathways are Signaling by GPCR and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity. [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Cytosolic DNA-sensing pathway (hsa04623 )
Epstein-Barr virus infection (hsa05169 )
Hepatitis C (hsa05160 )
IL-17 signaling pathway (hsa04657 )
Influenza A (hsa05164 )
RIG-I-like receptor signaling pathway (hsa04622 )
TNF signaling pathway (hsa04668 )
Toll-like receptor signaling pathway (hsa04620 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CXL10_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Candida albicans (budding yeasts) MIC00317
             Description Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection. [2]
         Lactobacillus casei (firmicutes) MIC00707
             Description Lactobacillus casei induced IP-10 ubiquitination. [3]
         Mycobacterium ulcerans (actinobacteria) MIC00852
             Description Mycobacterium marinum caused higher expression of chemokines including CXCL10. [4]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description Pseudomonas aeruginosa keratitis identified CXCL10 as a major chemokine induced by Pseudomonas aeruginosa infection. [2]
         Streptococcus pneumoniae (firmicutes) MIC01263
             Description Streptococcus pneumoniae contributes to a faster and possibly higher level of CXCL10/IP-10 expression induced by RSV infection in human MDMs. [5]
References
1 NF-B signaling regulates cell-autonomous regulation of CXCL10 in breast cancer 4T1 cells.Exp Mol Med. 2017 Feb 17;49(2):e295. doi: 10.1038/emm.2016.148.
2 Flagellin-induced expression of CXCL10 mediates direct fungal killing and recruitment of NK cells to the cornea in response to Candida albicans infection.Eur J Immunol. 2014 Sep;44(9):2667-79. doi: 10.1002/eji.201444490. Epub 2014 Aug 14.
3 Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation.PLoS One. 2009;4(2):e4365. doi: 10.1371/journal.pone.0004365. Epub 2009 Feb 6.
4 Mycobacterium marinum: a potential immunotherapy for Mycobacterium tuberculosis infection. Drug Des Devel Ther. 2013 Jul 29;7:669-80. doi: 10.2147/DDDT.S45197. Print 2013.
5 RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection.Int J Mol Sci. 2017 Dec 7;18(12):2654. doi: 10.3390/ijms18122654.

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