General Information of HIF (ID: HIFM0077)
HIF Name	C-X-C motif chemokine 14
HIF Synonym(s)	Cxcl14, BRAK
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Cytokine
Description	CXCL14 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Pfam	Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway	Chemokine signaling pathway (hsa04062 )
	Cytokine-cytokine receptor interaction (hsa04060 )
	Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CXL14_HUMAN
	APD ID	AP01373

Microbe Species (MIC) Regulated by This HIF
Candida albicans (budding yeasts)			MIC00317
Description	A concentration of 1M CXCL14 induced >99% killing of Streptococcus mitis.				[2]
Escherichia coli (enterobacteria)			MIC00516
Description	The recombinant CXCL14 demonstrates antimicrobial effects against Escherichia coli at 10g/ml.				[3]
Pseudomonas aeruginosa (gamma-proteobacteria)			MIC01054
Description	A concentration of 1M CXCL14 induced >99% killing of Pseudomonas aeruginosa PAO1.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	The recombinant CXCL14 demonstrates antimicrobial effects against Escherichia coli at 10g/ml.				[2]
Streptococcus pyogenes (firmicutes)			MIC01267
Description	The expression of CXCL14 is completely degraded by the cysteine proteinase SpeB from a strictly human pathogen Streptococcus pyogenes.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	CXCL14 as an emerging immune and inflammatory modulator.J Inflamm (Lond). 2016 Jan 5;13:1. doi: 10.1186/s12950-015-0109-9. eCollection 2016.
3	Mucosal Microbiome Profiles Polygenic Irritable Bowel Syndrome in Mestizo Individuals.Front Cell Infect Microbiol. 2020 Mar 20;10:72. doi: 10.3389/fcimb.2020.00072. eCollection 2020.

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