Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0305)
HIF Name
Human neutrophil peptide-1
HIF Synonym(s)
Human Neutrophil Peptide-1, HNP-1, HNP1
HIF Classification
Antimicrobial peptide (AMP)
Description human neutrophil peptide-1 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
External Links
APD ID
AP00176
Microbe Species (MIC) Regulated by This HIF
         Escherichia coli (enterobacteria) MIC00516
             Description The lethal concentrations of HNP-1 for killing Escherichia coli is 1.0M. [2]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description Human neutrophil peptide-1(HNP-1) could kill the enzymatic activity of Pseudomonas aeruginosa. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Human neutrophil peptide-1(HNP-1) could kill the enzymatic activity of Staphylococcus aureus. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines.Antimicrob Agents Chemother. 2005 Nov;49(11):4561-6. doi: 10.1128/AAC.49.11.4561-4566.2005.

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