Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0092)
HIF Name
Human beta defensin 2
HIF Synonym(s)
Human Beta Defensin 2, hBD-2, BD-2, SAP1, Beta-defensin 4A
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Antibiotic; Antimicrobial; Defensin
Description Human beta defensin 2 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Beta defensin (PF00711 )
Pathway IL-17 signaling pathway (hsa04657 )
NOD-like receptor signaling pathway (hsa04621 )
Staphylococcus aureus infection (hsa05150 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
DFB4A_HUMAN
APD ID
AP00522
Microbe Species (MIC) Regulated by This HIF
         Candida albicans (budding yeasts) MIC00317
             Description HBD-2 has 21.4% effective for against Candida albicans. [2]
         Candida glabrata (budding yeasts) MIC01794
             Description The expression of HBD-2 are upregulated in Candida esophagitis. [3]
         Escherichia coli (enterobacteria) MIC00516
             Description Escherichia coli strains are able to induce secretion of hBD-2 from enterocytes. [4]
         Lactobacillus sp. (firmicutes) MIC00701
             Description Lactobacillus strains are able to induce secretion of hBD-2 from enterocytes. [4]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description HBD-2 has 21.4% effective for against Pseudomonas aeruginosa. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description HBD-2 has 21.4% effective for against Staphylococcus aureus. [2]
References
1 APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2 Bacteria in the intestine, helpful residents or enemies from within. Infect Immun. 2008 Aug;76(8):3360-73. doi: 10.1128/IAI.00187-08. Epub 2008 May 12.
3 The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.BMC Immunol. 2009 Jun 12;10:36. doi: 10.1186/1471-2172-10-36.
4 The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems.Front Immunol. 2019 Dec 17;10:2950. doi: 10.3389/fimmu.2019.02950. eCollection 2019.

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