Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01794)
MIC Name Candida glabrata (budding yeasts)
MIC Synonyms Torulopsis glabrata
Body Site Mucosa
Lineage Kingdom: Eukaryota
Phylum: Ascomycota
Class: Saccharomycetes
Order: Saccharomycetales
Family: Saccharomycetaceae
Genus: Nakaseomyces
Species: Candida glabrata
Oxygen Sensitivity Facultative aerobe
Microbial Metabolism Fermentative; Respiratory
Host Relationship Opportunistic pathogen
Description Candida glabrata is generally a commensal of human mucosal tissues, but in today's era of wider human immunodeficiency from various causes, C. glabrata is often the second or third most common cause of candidiasis as an opportunistic pathogen.
External Links Taxonomy ID
5478
Genome Assembly ID
ASM1011175v1
Host Immune Factors (HIFs)
          C-C motif chemokine 27
             HIF ID HIFM0029 HIF Info       Class Antimicrobial peptide (AMP)
             Description Candida antigens can express CCR10, which is the receptor for CCL27. [1]
          Human beta defensin 3
             HIF ID HIFM0079 HIF Info       Class Antimicrobial peptide (AMP)
             Description The expression of HBD-3 are upregulated in Candida esophagitis. [2]
          Human beta defensin 2
             HIF ID HIFM0092 HIF Info       Class Antimicrobial peptide (AMP)
             Description The expression of HBD-2 are upregulated in Candida esophagitis. [2]
          Non-secretory ribonuclease
             HIF ID HIFM0200 HIF Info       Class Antimicrobial peptide (AMP)
             Description RNase 2 had significant antimicrobial activity against Candida glabrata(p<0.0001). [3]
          Ribonuclease 8
             HIF ID HIFM0202 HIF Info       Class Antimicrobial peptide (AMP)
             Description RNase 8 had significant antimicrobial activity against Candida glabrata(p<0.0001). [3]
          Chromogranin A-N46
             HIF ID HIFM0285 HIF Info       Class Antimicrobial peptide (AMP)
             Description CGA-N46 could inhibite the growth of Candida species by decreasing intracellular reactive oxygen species levels. [4]
          Polymorphonuclear leukocytes
             HIF ID HIFC0017 HIF Info       Class Granulocytes (Gra)
             Description Candida glabrata can induce protection against a lethal Candida albicans intra-abdominal infections that is mediated by polymorphonuclear leukocytes. [5]
Environmental Factor(s)
             Disbiome ID
      1225
             aBiofilm Organism
      Candida glabrata
References
1 Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi.Infect Immun. 2005 Jul;73(7):3896-902. doi: 10.1128/IAI.73.7.3896-3902.2005.
2 The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.BMC Immunol. 2009 Jun 12;10:36. doi: 10.1186/1471-2172-10-36.
3 RNase 1, 2, 5 & 8 role in innate immunity: Strain specific antimicrobial activity.Int J Biol Macromol. 2020 Jun 3;160:1042-1049. doi: 10.1016/j.ijbiomac.2020.06.001. Online ahead of print.
4 Protective effect of a novel antifungal peptide derived from human chromogranin a on the immunity of mice infected with Candida krusei.Exp Ther Med. 2017 May;13(5):2429-2434. doi: 10.3892/etm.2017.4290. Epub 2017 Mar 30.
5 Immune Protection against Lethal Fungal-Bacterial Intra-Abdominal Infections.mBio. 2018 Jan 16;9(1):e01472-17. doi: 10.1128/mBio.01472-17.

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