Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0200)
HIF Name
Non-secretory ribonuclease
HIF Synonym(s)
RNase 2, EDN, Eosinophil-Derived Neurotoxin
HIF Classification
Antimicrobial peptide (AMP)
Molecular Function
Endonuclease; Hydrolase; Lyase; Nuclease
Description RNase 2 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system. [1]
Pfam Pancreatic ribonuclease (PF00074 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
RNAS2_HUMAN
APD ID
AP02339
Microbe Species (MIC) Regulated by This HIF
         Candida albicans (budding yeasts) MIC00317
             Description RNase 2 had significant antimicrobial activity against Candida albicans(p<0.0001). [2]
         Candida glabrata (budding yeasts) MIC01794
             Description RNase 2 had significant antimicrobial activity against Candida glabrata(p<0.0001). [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description RNase 2 had significant antimicrobial activity against Staphylococcus aureus(p<0.0001). [2]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description RNase 2 had significant antimicrobial activity against Streptococcus thermophilus(p<0.0001). [2]
References
1 Antimicrobial peptides and the skin immune defense system.J Allergy Clin Immunol. 2008 Aug;122(2):261-6. doi: 10.1016/j.jaci.2008.03.027. Epub 2008 Apr 25.
2 RNase 1, 2, 5 & 8 role in innate immunity: Strain specific antimicrobial activity.Int J Biol Macromol. 2020 Jun 3;160:1042-1049. doi: 10.1016/j.ijbiomac.2020.06.001. Online ahead of print.

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