Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01272)
MIC Name Streptococcus thermophilus (firmicutes)
MIC Synonyms Streptococcus salivarius subsp. thermophilus
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus thermophilus
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative; Proteolysis
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 1929905
No. of Coding Genes 2037
No. of Non-Coding Genes 82
No. of Small Non-Coding Genes 82
No. of Gene Transcripts 2122
No. of Pseudogenes 3
No. of Base Pairs 1861792
Description Streptococcus thermophilus also known as Streptococcus salivarius subsp. thermophilus is a Gram-positive bacterium, and a fermentative facultative anaerobe, of the viridans group. It is known associated with periodontal disease.
External Links Taxonomy ID
1308
Genome Assembly ID
ASM97166v1
GOLD Organism ID
Go0000524
Disease Relevance
          Colorectal cancer  [ICD-11: 2B91]
             Description The numbers of Streptococcus thermophilus were decreased in feces from patients with colorectal adenoma or cancer. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Streptococcus thermophiles is associated with inflammatory bowel disease. [2]
          Periodontal disease  [ICD-11: DA0C]
             Description Periodontal disease was associated with Streptococcus thermophilus infection. [3]
Host Genetic Factors (HGFs)
          rs513735
             HGF ID HGF1262 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs513735 SNP was significantly associated with the abundance of Streptococcus thermophilus (p-value<1.00E-08). [4]
          rs12195861
             HGF ID HGF1773 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs12195861 SNP was significantly associated with the abundance of Streptococcus thermophilus (p-value<1.00E-08). [4]
Host Immune Factors (HIFs)
          Non-secretory ribonuclease
             HIF ID HIFM0200 HIF Info       Class Antimicrobial peptide (AMP)
             Description RNase 2 had significant antimicrobial activity against Streptococcus thermophilus(p<0.0001). [5]
          Ribonuclease 8
             HIF ID HIFM0202 HIF Info       Class Antimicrobial peptide (AMP)
             Description RNase 8 had significant antimicrobial activity against Streptococcus thermophilus(p<0.0001). [5]
          Granulocyte-macrophage colony-stimulating factor
             HIF ID HIFM0066 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus thermophilus decreased the mRNA expression of CSF-2. [6]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus thermophilus 285 infection could upregulated IL-10 expression. [6]
          Interferon-18
             HIF ID HIFM0136 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus thermophilus 285 decreased mRNA expression IL-18. [6]
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus thermophilus 285 upregulated expression of IL-1alpha. [6]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus thermophilus alters cytokine IL-6 expression levels(25.12 0.61 fold ) of peripheral blood mononuclear cell. [6]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Chemokine CXCL8 is upregulated (11.26 0.27 fold )following Streptococcus thermophilus culture. [6]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Streptococcus thermophilus 285 could upregulate IFN-Gamma. [6]
          Natural Killer cells
             HIF ID HIFC0028 HIF Info       Class Natural killer cells (NKCs)
             Description NK cells secreted colony-stimulating factor (CSF)-2 which was significantly increased after co-culturing peripheral blood mononuclear cell with Streptococcus thermophilus bacteria. [6]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description T cells can secrete GM-CSF which enables cell proliferation and differentiation and stimulates the production of various immune cells in fighting againts Streptococcus thermophilus infection. [6]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description Streptococcus thermophilus 285 promoted Th2 polarization. [6]
          Toll-like receptor 1
             HIF ID HIFM0216 HIF Info       Class Toll-like receptor (TLR)
             Description Streptococcus thermophilus decreased mRNA expression of TLR1. [6]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Streptococcus thermophilus could the decreased mRNA expression of TLR2. [6]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description Streptococcus thermophilus decreased mRNA expression of TLR4. [6]
          Toll-like receptor 8
             HIF ID HIFM0222 HIF Info       Class Toll-like receptor (TLR)
             Description Streptococcus thermophilus decreased mRNA expression of TLR8. [6]
Environmental Factor(s)
             Disbiome ID
      5
             gutMDisorder ID
      gm0624
References
1 Intestinal microbiota, chronic inflammation, and colorectal cancer. Intest Res. 2018 Jul;16(3):338-345. doi: 10.5217/ir.2018.16.3.338. Epub 2018 Jul 27.
2 Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases. Microbiome. 2019 Jan 3;7(1):1. doi: 10.1186/s40168-018-0604-3.
3 Competition between yogurt probiotics and periodontal pathogens in vitro. Acta Odontol Scand. 2010 Sep;68(5):261-8. doi: 10.3109/00016357.2010.492235.
4 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
5 RNase 1, 2, 5 & 8 role in innate immunity: Strain specific antimicrobial activity.Int J Biol Macromol. 2020 Jun 3;160:1042-1049. doi: 10.1016/j.ijbiomac.2020.06.001. Online ahead of print.
6 Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS One. 2020 Feb 11;15(2):e0228531. doi: 10.1371/journal.pone.0228531. eCollection 2020.

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