General Information of HIF (ID: HIFM0222)
HIF Name	Toll-like receptor 8
HIF Synonym(s)	toll like receptor 8, TLR8, CD288
HIF Classification	Toll-like receptor (TLR)
Molecular Function	Receptor
Description	TLR8 (Toll Like Receptor 8) is a Protein Coding gene				[1]
Pfam	Leucine rich repeat (PF13855 )
	TIR domain (PF01582 )
Pathway	Toll-like receptor signaling pathway (hsa04620 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	TLR8_HUMAN

Microbe Species (MIC) Regulated by This HIF
Methanosphaera stadtmanae (euryarchaeotes)			MIC00807
Description	The human-associated archaeon Methanosphaera stadtmanae is recognized through its RNA and induces TLR8-dependent NLRP3 inflammasome activation.				[2]
Streptococcus thermophilus (firmicutes)			MIC01272
Description	Streptococcus thermophilus decreased mRNA expression of TLR8.				[3]

References
1	Endosomal TLR-8 Senses microRNA-1294 Resulting in the Production of NFB Dependent Cytokines.Front Immunol. 2019 Dec 6;10:2860. doi: 10.3389/fimmu.2019.02860. eCollection 2019.
2	The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation. Front Immunol. 2017 Nov 13;8:1535. doi: 10.3389/fimmu.2017.01535. eCollection 2017.
3	Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS One. 2020 Feb 11;15(2):e0228531. doi: 10.1371/journal.pone.0228531. eCollection 2020.

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