| General Information of MIC (ID: MIC00807) |
| MIC Name |
Methanosphaera stadtmanae (euryarchaeotes)
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| MIC Synonyms |
Methanosphaera stadtmaniae
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| Body Site |
Gut
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| Lineage |
Kingdom: Archaea
Phylum: Euryarchaeota
Class: Methanobacteria
Order: Methanobacteriales
Family: Methanobacteriaceae
Genus: Methanosphaera
Species: Methanosphaera stadtmanae
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| Oxygen Sensitivity |
Anaerobe
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| Microbial Metabolism |
Energy metabolism
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| Gram |
Positive
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| Host Relationship |
Commensal
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| Genome Size (bp) |
1767403
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| Description |
Methanosphaera stadtmanae is an archaeon organism that lives in the human intestine. It can help prevent chronic inflammatory diseases of the intestine.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Disease Relevance |
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| Inflammatory bowel disease [ICD-11: DD72] |
| Description |
Methanosphaera stadtmanae was a strong inducer of the inflammatory response in inflammatory bowel disease. |
[1] |
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| Host Immune Factors (HIFs) |
| Toll-like receptor 8 |
| HIF ID |
HIFM0222 |
HIF Info
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Class |
Toll-like receptor (TLR) |
| Description |
The human-associated archaeon Methanosphaera stadtmanae is recognized through its RNA and induces TLR8-dependent NLRP3 inflammasome activation. |
[2] |
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| Environmental Factor(s) |
| Disbiome ID |
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| References |
| 1 |
Increased prevalence of Methanosphaera stadtmanae in inflammatory bowel diseases. PLoS One. 2014 Feb 3;9(2):e87734. doi: 10.1371/journal.pone.0087734. eCollection 2014.
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| 2 |
The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation. Front Immunol. 2017 Nov 13;8:1535. doi: 10.3389/fimmu.2017.01535. eCollection 2017.
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