Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0216)
HIF Name
Toll-like receptor 1
HIF Synonym(s)
toll like receptor 1, TIL, CD281, rsc786, TIL. LPRS5, TLR1
HIF Classification
Toll-like receptor (TLR)
Molecular Function
Hydrolase; Receptor
Description Toll-like receptors (TLRs) are a family of 10 (TLR1TLR10) receptor proteins found on the cells of the innate immune system that are vital for the recognition of microbial components known as pathogen-associated molecular patterns (PAMPs). [1]
Pfam Leucine rich repeat C-terminal domain (PF01463 )
Leucine rich repeat (PF13855 )
TIR domain (PF01582 )
Pathway Toll-like receptor signaling pathway (hsa04620 )
Tuberculosis (hsa05152 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TLR1_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Mycoplasma genitalium (mycoplasmas) MIC00870
             Description TLR1 activation is associated with Mycoplasma genitalium recognition. [2]
         Mycoplasma synoviae (mycoplasmas) MIC00877
             Description The expression of TLR1 and TLR2 were significantly down-regulated after 6 h and 24 h (p < 0.001) with Mycoplasma synoviae infection. [3]
         Porphyromonas gingivalis (CFB bacteria) MIC01000
             Description TLR2/1 ligation induces cytokine and chemokine release which is antagonized by Porphyromonas gingivalis. [4]
         Pseudomonas fluorescens (gamma-proteobacteria) MIC01056
             Description Pseudomonas fluorescens is associated with the expression of TLR-1. [5]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description Streptococcus thermophilus decreased mRNA expression of TLR1. [6]
References
1 TNF alpha and the TNF receptor superfamily: structure-function relationship(s).Microsc Res Tech. 2000 Aug 1;50(3):184-95. doi: 10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H.
2 Mycoplasma genitalium can modulate the local immune response in patients with endometriosis. Fertil Steril. 2018 Mar;109(3):549-560.e4. doi: 10.1016/j.fertnstert.2017.11.009. Epub 2018 Feb 7.
3 Diacylated lipopeptide from Mycoplasma synoviae mediates TLR15 induced innate immune responses. Vet Res. 2013 Oct 17;44(1):99. doi: 10.1186/1297-9716-44-99.
4 The role of Porphyromonas gingivalis gingipains in platelet activation and innate immune modulation. Mol Oral Microbiol. 2015 Feb;30(1):62-73. doi: 10.1111/omi.12067. Epub 2014 Oct 3.
5 Polyvalent protective immunogens identified from outer membrane proteins of Vibrio parahaemolyticus and their induced innate immune response. Fish Shellfish Immunol. 2018 Jan;72:104-110. doi: 10.1016/j.fsi.2017.10.046. Epub 2017 Oct 28.
6 Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS One. 2020 Feb 11;15(2):e0228531. doi: 10.1371/journal.pone.0228531. eCollection 2020.

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