General Information of MIC (ID: MIC00870)
MIC Name	Mycoplasma genitalium (mycoplasmas)
Body Site	Vagina
Lineage	Kingdom: Bacteria Phylum: Tenericutes Class: Mollicutes Order: Mycoplasmatales Family: Mycoplasmataceae Genus: Mycoplasma Species: Mycoplasma genitalium
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Saccharolytic; Fermentative
Gram	Positive
Host Relationship	Pathogen
Genome Size (bp)	580076
Description	Mycoplasma genitalium is a sexually transmitted, small and pathogenic bacterium that lives on the skin cells of the urinary and genital tracts in humans.
External Links	Taxonomy ID	2097
	Genome Assembly ID	ASM29248v1
	GOLD Organism ID	Go0189905
Disease Relevance
Female pelvic inflammatory disease  [ICD-11: GA05]
Description	Mycoplasma genitalium can cause pelvic inflammatory disease among other complications.				[1]
Obesity  [ICD-11: 5B81]
Description	Diet-induced obesity produced a bloom in a single uncultured clade within the Mollicutes class of the Firmicutes, which was diminished by subsequent dietary manipulations that limit weight gain.				[2]

Host Genetic Factors (HGFs)
rs1800795
HGF ID	HGF1720	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The variant gene IL-6 of innate immunity rs1800795 is significantly associated with the abundance of gut micriobiota Mollicutes (p-value=0.0181).				[3]

Host Immune Factors (HIFs)
Interleukin-1 beta
HIF ID	HIFM0138	HIF Info	Class	Cytokine (Cyt)
Description	There is no statistically significant differences in the levels of IL-1beta(p>0.05)in the Mollicutes infection with the health.				[4]
Interferon-6
HIF ID	HIFM0151	HIF Info	Class	Cytokine (Cyt)
Description	There is no statistically significant differences in the levels of IL-1beta(p>0.05)in the Mollicutes infection with the health.				[4]
C-X-C motif chemokine 8
HIF ID	HIFM0153	HIF Info	Class	Cytokine (Cyt)
Description	There is no statistically significant differences in the levels of IL-8(p>0.05)in the Mollicutes infection with the health.				[4]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	Mollicutes is associated with the level of TNF-Alpha.				[4]
Interferon gamma
HIF ID	HIFM0260	HIF Info	Class	Cytokine (Cyt)
Description	At the class level, Mollicutes is associated with IFN-Gamma.				[4]
Toll-like receptor 1
HIF ID	HIFM0216	HIF Info	Class	Toll-like receptor (TLR)
Description	TLR1 activation is associated with Mycoplasma genitalium recognition.				[4]
Toll-like receptor 2
HIF ID	HIFM0217	HIF Info	Class	Toll-like receptor (TLR)
Description	Mycoplasma genitalium is associated with TLR2 expression.				[4]
Toll-like receptor 6
HIF ID	HIFM0221	HIF Info	Class	Toll-like receptor (TLR)
Description	Mycoplasma genitaliummediated inflammatory process could be dependent on TLR6.				[4]

Environmental Factor(s)
Disbiome ID			797

References
1	The two-sided role of the vaginal microbiome in Chlamydia trachomatis and Mycoplasma genitalium pathogenesis. J Reprod Immunol. 2018 Nov;130:11-17. doi: 10.1016/j.jri.2018.08.006. Epub 2018 Aug 22.
2	Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe. 2008 Apr 17;3(4):213-23. doi: 10.1016/j.chom.2008.02.015.
3	Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
4	Mycoplasma genitalium can modulate the local immune response in patients with endometriosis. Fertil Steril. 2018 Mar;109(3):549-560.e4. doi: 10.1016/j.fertnstert.2017.11.009. Epub 2018 Feb 7.

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