General Information of HIF (ID: HIFM0221)
HIF Name	Toll-like receptor 6
HIF Synonym(s)	toll like receptor 6, CD286
HIF Classification	Toll-like receptor (TLR)
Molecular Function	Hydrolase; Receptor
Description	TLR6 (Toll Like Receptor 6) is a Protein Coding gene.				[1]
Pfam	Leucine rich repeat C-terminal domain (PF01463 )
	Leucine rich repeat (PF13855 )
	TIR domain (PF01582 )
Pathway	Chagas disease (American trypanosomiasis) (hsa05142 )
	Phagosome (hsa04145 )
	Salmonella infection (hsa05132 )
	Toll-like receptor signaling pathway (hsa04620 )
	Tuberculosis (hsa05152 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	TLR6_HUMAN

Microbe Species (MIC) Regulated by This HIF
Mycoplasma genitalium (mycoplasmas)			MIC00870
Description	Mycoplasma genitaliummediated inflammatory process could be dependent on TLR6.				[2]
Paeniclostridium sordellii (firmicutes)			MIC00417
Description	Innate immune recognition of, and response to, cell-associated components of C. sordellii and other clostridial pathogens are mediated by TLR2 in combination with TLR6.				[3]
Yersinia pestis (enterobacteria)			MIC01401
Description	TLR6 drove differentiation of tolerogenic DC and contributed to LcrV-mediated plague (caused by Yersinia pestis Infection) pathogenesis.				[4]

References
1	Association of a common TLR-6 polymorphism with coronary artery disease - implications for healthy ageing. Immun Ageing. 2013 Oct 30;10(1):43. doi: 10.1186/1742-4933-10-43.
2	Mycoplasma genitalium can modulate the local immune response in patients with endometriosis. Fertil Steril. 2018 Mar;109(3):549-560.e4. doi: 10.1016/j.fertnstert.2017.11.009. Epub 2018 Feb 7.
3	Innate immune recognition of, and response to, Clostridium sordellii. Anaerobe. 2010 Apr;16(2):125-30. doi: 10.1016/j.anaerobe.2009.06.004. Epub 2009 Jun 25.
4	Immunology of Yersinia pestis Infection. Adv Exp Med Biol. 2016;918:273-292. doi: 10.1007/978-94-024-0890-4_10.

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