Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01401)
MIC Name Yersinia pestis (enterobacteria)
MIC Synonyms Bacterium pestis
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Yersiniaceae
Genus: Yersinia
Species: Yersinia pestis
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative
Gram Negative
Description Yersinia pestis is a Gram-negative, non-motile, rod-shaped, coccobacillus bacterium, with no spores. It is a facultative anaerobic organism that can infect humans via the Oriental rat flea.
External Links Taxonomy ID
632
Genome Assembly ID
ASM379822v1
GOLD Organism ID
Go0037413
Disease Relevance
          Providencia alcalifaciens gastroenteritis  [ICD-11: 1A40]
             Description Yersinia is a cause of food-borne gastroenteritis worldwide. [1]
Host Immune Factors (HIFs)
          C-X-C motif chemokine 1
             HIF ID HIFM0109 HIF Info       Class Cytokine (Cyt)
             Description There is no significant changes observed in the lungs in the levels of the major neutrophil chemoattractant CXCL1 after pulmonary infection with a fully virulent Yersinia pestis strain. [2]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Yersinia pestis can suppress the production of cytokines and chemokines IL-10 through reducing enzyme activity. [2]
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description Bone marrowderived neutrophils transferred to IL-17A KO mice after 20 days could mitigate the severe inflammatory injuries challenged with Yersinia pestis(p<0.001). [2]
          Interferon-18
             HIF ID HIFM0136 HIF Info       Class Cytokine (Cyt)
             Description Yersinia pestis is associated with IL-18 expression. [2]
          Protransforming growth factor alpha
             HIF ID HIFM0212 HIF Info       Class Cytokine (Cyt)
             Description Yersinia pestis causes apoptosis and poptotic cells are cleared by phagocytes to trigger production of the anti-infl ammatory cytokines TGFalpa. [2]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Specific CD8 T cellmediated protection against pneumonic plague (caused by Yersinia pestis Infection) is dependent on TNFAlpha and IFNGamma, but not on perforin. [2]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Specific CD8 T cellmediated protection against pneumonic plague (caused by Yersinia pestis Infection) is dependent on TNFAlpha and IFNGamma, but not on perforin. [2]
          Interleukin-1
             HIF ID HIFM0263 HIF Info       Class Cytokine (Cyt)
             Description When Yersinia pestis grow in the flea gut (21 26 C), they produce a typical hexa-acylated LPS, which activates TLR4-mediated immune signaling to induce the expression of proinfl ammatory cytokines (TNFAlpha, IL-1, IL-6, and IL-8). [2]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Relative abundances of Yersinia pestis is associated with dendritic cells response. [2]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Neutrophil was the first defense against Yersinia pestis invading through phagocytosis and killing. [2]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description Yersinia pestis was associated with IgG1 response. [3]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Yersinia pestis is associated with IgG response. [2]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Macrophage was the first defense against Yersinia pestis invading through phagocytosis and killing. [2]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description LPS in Yersinia pestis upregulates cell survival genes and inflammatory cytokine production controlled by MAPK and NF-kB. [2]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Yersinia could paticipate in Th1 responses. [3]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description Yersinia could paticipate in Th2 responses. [3]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description YopE of Yersinia pestis was found to contain a dominant CD8 T cell epitope, which can be recognized by nearly 20 % of pulmonary CD8 T cells. [2]
          Toll-like receptor 6
             HIF ID HIFM0221 HIF Info       Class Toll-like receptor (TLR)
             Description TLR6 drove differentiation of tolerogenic DC and contributed to LcrV-mediated plague (caused by Yersinia pestis Infection) pathogenesis. [2]
Environmental Factor(s)
             Disbiome ID
      718
References
1 Directional gene flow and ecological separation in Yersinia enterocolitica. Microb Genom. 2015 Sep 29;1(3):e000030. doi: 10.1099/mgen.0.000030. eCollection 2015 Sep.
2 Immunology of Yersinia pestis Infection. Adv Exp Med Biol. 2016;918:273-292. doi: 10.1007/978-94-024-0890-4_10.
3 Induction of Protective Antiplague Immune Responses by Self-Adjuvanting Bionanoparticles Derived from Engineered Yersinia pestis. Infect Immun. 2020 Apr 20;88(5):e00081-20. doi: 10.1128/IAI.00081-20. Print 2020 Apr 20.

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