Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0085)
HIF Name
T helper type 2 cells
HIF Synonym(s)
T-helper type 2, T helper type 2(Th2) cells
HIF Classification
T cells (TCs)
Description T helper type 2(Th2)cellsare a subset of CD4 + effectorT cellsthat is required for host defense against intracellular viral and bacterial pathogens. [1]
Microbe Species (MIC) Regulated by This HIF
         Bacillus clausii (firmicutes) MIC01420
             Description Bacillus clausii was able to ameliorate Salmonella-induced dysbiosis and inflammation in Th2-biased subject. [2]
         Clostridium butyricum (firmicutes) MIC00388
             Description Clostridium butyricum CGMCC0313.1 reduces pancreas inflammation and reversed the imbalance in Th1/Th2/Th17/Tregs. [3]
         Clostridium leptum (firmicutes) MIC00402
             Description Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung, resulting in the inhibition of Th2 cell responses. [4]
         Dialister pneumosintes (firmicutes) MIC00506
             Description An increased levels of Dialister was accompanied by a decrease in T-helper 2 (Th2) responses and altered Th1/Th2 ratios. [5]
         Gardnerella vaginalis (actinobacteria) MIC00626
             Description Th2 cells secreted IL5 and IL13 which were significantly associated with the perturbation of Gardnerella vaginalis. [6]
         Helicobacter cinaedi (epsilon-proteobacteria) MIC00665
             Description IgG1 serological markers for Th2 responses were significantly increased in subjects infected with WT Helicobacter cinaedi compared with uninfected controls. [7]
         Heligmosomoides polygyrus (nematodes) MIC02012
             Description Heligmosomoides polygyrus infection resulted in the increasement of T helper type 2 (Th2) cells in diabetes mellitus patients. [8]
         Lactobacillus helveticus (firmicutes) MIC01410
             Description Lactobacillus helveticus OFS 1515 alleviated proinflammatory cytokines TNF-, IFN- and IL-1 as well as IL-4 produced by Th2 cells. [9]
         Lactobacillus paracasei (firmicutes) MIC00726
             Description Lactobacillus paracasei OFS 0291 alleviated proinflammatory cytokines TNF-, IFN- and IL-1 as well as IL-4 produced by Th2 cells. [9]
         Lactobacillus reuteri (firmicutes) MIC00731
             Description Lactobacillus reuteri could mediate suppression of Th2 responses. [10]
         Leuconostoc mesenteroides (firmicutes) MIC00766
             Description Leuconostoc mesenteroides can induce of Th1 cytokines under Th2-type conditions. [11]
         Megasphaera elsdenii (firmicutes) MIC00788
             Description Prevotella timonensis could inhibite the enzyme activity to suppress T-helper type 2 cells responses. [12]
         Mycobacterium ulcerans (actinobacteria) MIC00852
             Description Mycobacterium marinum induced significant Th2 cell immunity. [13]
         Mycobacterium parascrofulaceum (actinobacteria) MIC00853
             Description Th2-type immunity might play important roles in the defense against Mycobacterium parascrofulaceum in the exudative lesion. [14]
         Neisseria meningitidis (beta-proteobacteria) MIC00891
             Description Neisseria meningitidis induced more TH2 cytokine (higher IL-10/IFN- ratio) in older children. [15]
         Pantoea agglomerans (enterobacteria) MIC00944
             Description Lipopolysaccharides derived from Pantoea agglomerans stimulated macrophages which normalized the T-helper type 1 and 2 (Th1/Th2) immune system balance. [16]
         Pseudomonas aeruginosa (gamma-proteobacteria) MIC01054
             Description A kill or inactivate but metabolically active Pseudomonas aeruginosa(deactivate enzymatic activity) could elicit Th2 pathways of cell-mediated immune responses. [17]
         Rickettsia prowazekii (alpha-proteobacteria) MIC01108
             Description Th2 response was associated with IgG1 secretion during Rickettsia prowazekii infection. [18]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description Salmonella typhimurium could increase T helper type 2(Th2)cells responses. [19]
         Schistosoma mansoni (flatworms) MIC01158
             Description Schistosoma mansoni infection resulted in the increasement of T helper type 2(Th2) cells in diabetes mellitus patients. [8]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description Streptococcus thermophilus 285 promoted Th2 polarization. [20]
         Trichinella spiralis (nematodes) MIC01802
             Description Trichinella spiralis infection resulted in the increasement of T helper type 2 (Th2) cells in diabetes mellitus patients. [8]
         Yersinia pestis (enterobacteria) MIC01401
             Description Yersinia could paticipate in Th2 responses. [21]
References
1 Thymic stromal lymphopoietin drives the development of IL-13(+) Th2 cells.Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1033-1038. doi: 10.1073/pnas.1714348115. Epub 2018 Jan 16.
2 Probiotics L. acidophilus and B. clausii Modulate Gut Microbiota in Th1- and Th2-Biased Mice to Ameliorate Salmonella Typhimurium-Induced Diarrhea. Probiotics Antimicrob Proteins. 2019 Sep;11(3):887-904. doi: 10.1007/s12602-018-9436-5.
3 Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
4 Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
5 Host-bacterial interactions during induction and resolution of experimental gingivitis in current smokers. J Periodontol. 2013 Jan;84(1):32-40. doi: 10.1902/jop.2012.110662. Epub 2012 Mar 16.
6 In vivo microbiome and associated immune markers: New insights into the pathogenesis of vaginal dysbiosis. Sci Rep. 2018 Feb 2;8(1):2307. doi: 10.1038/s41598-018-20649-x.
7 Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice. Infect Immun. 2012 Mar;80(3):921-8. doi: 10.1128/IAI.05477-11. Epub 2011 Dec 19.
8 Microbiota in T-cell homeostasis and inflammatory diseases.Exp Mol Med. 2017 May 26;49(5):e340. doi: 10.1038/emm.2017.36.
9 Lactobacillus sp. improved microbiota and metabolite profiles of aging rats. Pharmacol Res. 2019 Aug;146:104312. doi: 10.1016/j.phrs.2019.104312. Epub 2019 Jun 14.
10 Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells. Front Immunol. 2019 Jun 4;10:1235. doi: 10.3389/fimmu.2019.01235. eCollection 2019.
11 Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK. Cytokine. 2009 May;46(2):283-9. doi: 10.1016/j.cyto.2009.02.005. Epub 2009 Mar 18.
12 Vaginal dysbiosis associated-bacteria Megasphaera elsdenii and Prevotella timonensis induce immune activation via dendritic cells. J Reprod Immunol. 2020 Apr;138:103085. doi: 10.1016/j.jri.2020.103085. Epub 2020 Jan 22.
13 Mycobacterium marinum: a potential immunotherapy for Mycobacterium tuberculosis infection. Drug Des Devel Ther. 2013 Jul 29;7:669-80. doi: 10.2147/DDDT.S45197. Print 2013.
14 Immunopathological characteristics of immune reconstitution inflammatory syndrome caused by Mycobacterium parascrofulaceum infection in a patient with AIDS. Pathol Res Pract. 2011 Apr 15;207(4):262-70. doi: 10.1016/j.prp.2011.01.003. Epub 2011 Mar 4.
15 Cellular immune responses to Neisseria meningitidis in children. Infect Immun. 1999 May;67(5):2452-63.
16 Improvement of allergic dermatitis via regulation of the Th1/Th2 immune system balance by macrophages activated with lipopolysaccharide derived from Pantoea agglomerans (IP-PA1). Anticancer Res. 2009 Nov;29(11):4867-70.
17 Killed but metabolically active Pseudomonas aeruginosa-based vaccine induces protective humoral- and cell-mediated immunity against Pseudomonas aeruginosa pulmonary infections. Vaccine. 2018 Mar 27;36(14):1893-1900. doi: 10.1016/j.vaccine.2018.02.040. Epub 2018 Mar 2.
18 A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. Microbes Infect. 2007 Jun;9(7):898-906. doi: 10.1016/j.micinf.2007.03.008. Epub 2007 Mar 21.
19 Salmonella Typhimurium, the major causative agent of foodborne illness inactivated by a phage lysis system provides effective protection against lethal challenge by induction of robust cell-mediated immune responses and activation of dendritic cells. Vet Res. 2017 Oct 25;48(1):66. doi: 10.1186/s13567-017-0474-x.
20 Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS One. 2020 Feb 11;15(2):e0228531. doi: 10.1371/journal.pone.0228531. eCollection 2020.
21 Induction of Protective Antiplague Immune Responses by Self-Adjuvanting Bionanoparticles Derived from Engineered Yersinia pestis. Infect Immun. 2020 Apr 20;88(5):e00081-20. doi: 10.1128/IAI.00081-20. Print 2020 Apr 20.

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