Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00388)
MIC Name Clostridium butyricum (firmicutes)
MIC Synonyms Bacillus butyricus
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium butyricum
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 4922643
No. of Coding Genes 4042
No. of Non-Coding Genes 43
No. of Small Non-Coding Genes 43
No. of Gene Transcripts 4085
No. of Base Pairs 4922643
Description Clostridium butyricum is a strictly anaerobic, endospore forming, Gram positive, butyric acid producing bcillus. It is uncommonly reported as a human pathogen and is widely used as a probiotic in Asia (particularly in Japan, Korea and China). C.butyricum has been cultured from the stool of healthy children and adults.
External Links Taxonomy ID
1492
Genome Assembly ID
ASM78518v1
GOLD Organism ID
Go0041666
Disease Relevance
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Clostridium butyricum decreased post-weaning diarrhea by improving the intestinal morphology, intestinal microflora profile, and immune function. [1]
Host Immune Factors (HIFs)
          B- and T-lymphocyte attenuator
             HIF ID HIFM0009 HIF Info       Class Checkpoint molecule (CM)
             Description The continuous high expression of BTLA on CD4+ T cells in Live Clostridium butyricum therapy group. [2]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Clostridium butyricum CGMCC0313.1 might increase the IL-10 expression. [3]
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description Clostridium butyricum CGMCC0313.1 is associated with IL-17A expression. [3]
          Interferon-4
             HIF ID HIFM0149 HIF Info       Class Cytokine (Cyt)
             Description Clostridium butyricum CGMCC0313.1 is associated with IL-4 expression. [3]
          Transforming growth factor beta-2 proprotein
             HIF ID HIFM0213 HIF Info       Class Cytokine (Cyt)
             Description Clostridium butyricum CGMCC0313.1 is associated with TGF-Beta concentrations. [3]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Clostridium butyricum CGMCC0313.1 decreases systemic inflammation primarily by reducing IFN-gamma+CD4+ T cells. [3]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Protective T cells can response to Clostridium butyricum infection. [4]
          Regulatory T cells
             HIF ID HIFC0030 HIF Info       Class T cells (TCs)
             Description Clostridium butyricum CGMCC0313.1 could induce Tregs. [3]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Clostridium butyricum CGMCC0313.1 is associated with CD4+ T cells responses. [3]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Clostridium butyricum CGMCC0313.1 reduces pancreas inflammation and reversed the imbalance in Th1/Th2/Th17/Tregs. [3]
          Gammadelta+ T cells
             HIF ID HIFC0077 HIF Info       Class T cells (TCs)
             Description Intracellular staining for cytokine profile of T cells from the pancreas demonstrated a lower percentage of IFN-gamma+ in non-obese diabetic disease with Clostridium butyricum CGMCC0313.1 infection. [3]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Clostridium butyricum CGMCC0313.1 reduces pancreas inflammation and reversed the imbalance in Th1/Th2/Th17/Tregs. [3]
          T helper type 2 cells
             HIF ID HIFC0085 HIF Info       Class T cells (TCs)
             Description Clostridium butyricum CGMCC0313.1 reduces pancreas inflammation and reversed the imbalance in Th1/Th2/Th17/Tregs. [3]
          IL10+FOXP3+CD4+ regulatory T cells
             HIF ID HIFC0187 HIF Info       Class T cells (TCs)
             Description Clostridium butyricum is related to the differentiation of IL10+FOXP3+CD4+ Tregulatory cells Treg cells in the colon. [5]
Environmental Factor(s)
             Disbiome ID
      191
             gutMDisorder ID
      gm0187
References
1 Effects of dietary Clostridium butyricum supplementation on growth performance, intestinal development, and immune response of weaned piglets challenged with lipopolysaccharide. J Anim Sci Biotechnol. 2018 Aug 23;9:62. doi: 10.1186/s40104-018-0275-8. eCollection 2018.
2 Effects of clostridium butyricum and bifidobacterium on BTLA expression on CD4(+) T cells and lymphocyte differentiation in late preterm infants.Microb Pathog. 2016 Nov;100:112-118. doi: 10.1016/j.micpath.2016.09.008. Epub 2016 Sep 10.
3 Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
4 Gut Microbiota Interventions With Clostridium butyricum and Norfloxacin Modulate Immune Response in Experimental Autoimmune Encephalomyelitis Mice. Front Immunol. 2019 Jul 23;10:1662. doi: 10.3389/fimmu.2019.01662. eCollection 2019.
5 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.

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