Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0149)
HIF Name
Interferon-4
HIF Synonym(s)
interleukin 4, IL4, BSF1, IL-4, BCGF1, BSF-1, BCGF-1
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine; Growth factor
Description IL-4 is a ligand for IL4 receptor (as is IL13), and it induces the expression of class II MHC molecules on resting B-cells. [1]
Pfam Interleukin 4 (PF00727 )
Pathway Allograft rejection (hsa05330 )
Asthma (hsa05310 )
Autoimmune thyroid disease (hsa05320 )
Cytokine-cytokine receptor interaction (hsa04060 )
Fc epsilon RI signaling pathway (hsa04664 )
Hematopoietic cell lineage (hsa04640 )
IL-17 signaling pathway (hsa04657 )
Inflammatory bowel disease (IBD) (hsa05321 )
Intestinal immune network for IgA production (hsa04672 )
JAK-STAT signaling pathway (hsa04630 )
Leishmaniasis (hsa05140 )
PI3K-Akt signaling pathway (hsa04151 )
Pathways in cancer (hsa05200 )
T cell receptor signaling pathway (hsa04660 )
Th1 and Th2 cell differentiation (hsa04658 )
Th17 cell differentiation (hsa04659 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL4_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Brachyspira hyodysenteriae (spirochaetes) MIC00258
             Description The IL-4 concentrations in MLN culture supernatants were significantly (P < 0.05) increased in Brachyspira colonized mice. [2]
         Chlamydia abortus (chlamydias) MIC00347
             Description Chlamydo abortus was able to induce a good Th2 response and IL-4 production after immunization. [3]
         Clostridium butyricum (firmicutes) MIC00388
             Description Clostridium butyricum CGMCC0313.1 is associated with IL-4 expression. [4]
         Clostridium leptum (firmicutes) MIC00402
             Description IL-23 expression level is decreased in the Clostridium leptum infection mice. [5]
         Deltaproteobacteria (delta-proteobacteria) MIC00480
             Description Deltaproteobacteria has associations with the IL-4(p = 0.086;R2 = 0.562)in the heart tissue. [6]
         Escherichia coli (enterobacteria) MIC00516
             Description Splenic TFF2 in attenuating SR-induced reduced protective ability against Escherichia coli (E. coli) pneumonia and increased expression of IL-4. [7]
         Eubacterium saphenum (firmicutes) MIC00579
             Description The intracellular production of IL-4 in CD4+/CD8+ T cells was rather low during Eubacterium saphenum infection. [8]
         Faecalibacterium prausnitzii (firmicutes) MIC00590
             Description Faecalibacterium prausnitzii is associated with IL-4. [9]
         Glaesserella parasuis (gamma-proteobacteria) MIC00654
             Description IL-4 was expressed in significantly(p < 0.05)higher levels in spleen, pharyngeal lymph nodes, lung and brain of survivors undergoing severe Glassers disease following Haemophilus parasuis infection. [10]
         Helicobacter bilis (epsilon-proteobacteria) MIC00663
             Description Helicobacter bilis colonized mice produced lower levels of interleukin (IL)-4 than did lymphocytes Brachyspira hyodysenteriae. [2]
         Lactobacillus helveticus (firmicutes) MIC01410
             Description Lactobacillus helveticus OFS 1515 alleviated proinflammatory cytokines IL-1Beta. [11]
         Lactobacillus kefiranofaciens (firmicutes) MIC00723
             Description Lactobacillus kefiranofaciens could induce IL-4 expression. [12]
         Lactobacillus paracasei (firmicutes) MIC00726
             Description Lactobacillus paracasei OFS 0291 alleviated proinflammatory cytokines IL-1Beta. [11]
         Leptospira borgpetersenii (spirochaetes) MIC00758
             Description Leptospira borgpetersenii is associated with IL-4 expression. [13]
         Leuconostoc mesenteroides (firmicutes) MIC00766
             Description Leuconostoc mesenteroides could augment the production of IL-4 in vitro. [14]
         Methanobrevibacter smithii (euryarchaeotes) MIC00792
             Description Methanobrevibacter smithii is associated with IL-4 expression. [15]
         Mycobacterium leprae (actinobacteria) MIC00851
             Description Mycobacterium leprae could stimulate IL-4 expression. [16]
         Neisseria lactamica (beta-proteobacteria) MIC00888
             Description Neisseria lactamica PorB can increase the secretion of cytokines IL-4. [17]
         Nocardia farcinica (actinobacteria) MIC00915
             Description Spleen cell production of IL-4 remained low following stimulation with recombinant Mce1E protein, with no statistically significant differences after Nocardia farcinica infection. [18]
         Rhodococcus hoagii (actinobacteria) MIC01092
             Description Expression of IL-4 mRNA was significantly higher in monocyte-derived macrophages during Rhodococcus equi injection. [19]
         Streptococcus dysgalactiae (firmicutes) MIC01247
             Description The IL-4 expression was protective immunity against Streptococcus dysgalactiae. [20]
References
1 Characterization of cryptic allosteric site at IL-4R: New paradigm towards IL-4/IL-4R inhibition.Int J Biol Macromol. 2019 Feb 15;123:239-245. doi: 10.1016/j.ijbiomac.2018.10.204. Epub 2018 Nov 2.
2 Induction of differential immune reactivity to members of the flora of gnotobiotic mice following colonization with Helicobacter bilis or Brachyspira hyodysenteriae. Microbes Infect. 2006 May;8(6):1602-10. doi: 10.1016/j.micinf.2006.01.019. Epub 2006 Apr 18.
3 Immune response to Chlamydophila abortus POMP91B protein in the context of different Pathogen Associated Molecular Patterns (PAMP); role of antigen in the orientation of immune response. Toxins (Basel). 2009 Dec;1(2):59-73. doi: 10.3390/toxins1020059. Epub 2009 Oct 13.
4 Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
5 Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
6 Gut Dysbiosis and Adaptive Immune Response in Diet-induced Obesity vs. Systemic Inflammation. Front Microbiol. 2017 Jun 22;8:1157. doi: 10.3389/fmicb.2017.01157. eCollection 2017.
7 Dexmedetomidine alleviates sleep-restriction-mediated exaggeration of postoperative immunosuppression via splenic TFF2 in aged mice. Aging (Albany NY). 2020 Mar 22;12(6):5318-5335. doi: 10.18632/aging.102952. Epub 2020 Mar 22.
8 Intraperitoneal immune cell responses to Eubacterium saphenum in mice. Microbiol Immunol. 2001;45(1):29-37. doi: 10.1111/j.1348-0421.2001.tb01271.x.
9 Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.
10 Haemophilus parasuis: infection, immunity and enrofloxacin. Vet Res. 2015 Oct 28;46:128. doi: 10.1186/s13567-015-0263-3.
11 Lactobacillus sp. improved microbiota and metabolite profiles of aging rats. Pharmacol Res. 2019 Aug;146:104312. doi: 10.1016/j.phrs.2019.104312. Epub 2019 Jun 14.
12 Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity. Cytokine. 2006 Dec;36(5-6):254-60. doi: 10.1016/j.cyto.2007.01.003. Epub 2007 Mar 23.
13 Evaluation of type 1 immune response in naive and vaccinated animals following challenge with Leptospira borgpetersenii serovar Hardjo: involvement of WC1(+) gammadelta and CD4 T cells. Infect Immun. 2002 Nov;70(11):6147-57. doi: 10.1128/iai.70.11.6147-6157.2002.
14 Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK. Cytokine. 2009 May;46(2):283-9. doi: 10.1016/j.cyto.2009.02.005. Epub 2009 Mar 18.
15 Methanobrevibacter smithii archaeosomes-entrapped mzNL4-3 virus-like particles induce specific T helper 1-oriented cellular and humoral responses against HIV-1. Curr HIV Res. 2013 Sep;11(6):491-7. doi: 10.2174/1570162x11666131216125059.
16 Host immune responses induced by specific Mycobacterium leprae antigens in an overnight whole-blood assay correlate with the diagnosis of paucibacillary leprosy patients in China. PLoS Negl Trop Dis. 2019 Apr 24;13(4):e0007318. doi: 10.1371/journal.pntd.0007318. eCollection 2019 Apr.
17 The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant. Vaccine. 2008 Feb 6;26(6):786-96. doi: 10.1016/j.vaccine.2007.11.080. Epub 2007 Dec 26.
18 Cloning, Expression, Invasion, and Immunological Reactivity of a Mammalian Cell Entry Protein Encoded by the mce1 Operon of Nocardia farcinica. Front Microbiol. 2017 Feb 22;8:281. doi: 10.3389/fmicb.2017.00281. eCollection 2017.
19 Effects of age and macrophage lineage on intracellular survival and cytokine induction after infection with Rhodococcus equi. Vet Immunol Immunopathol. 2014 Jul 15;160(1-2):41-50. doi: 10.1016/j.vetimm.2014.03.010. Epub 2014 Mar 29.
20 Identification and characterization of CD4+ T-cell epitopes on GapC protein of Streptococcus dysgalactiae. Microb Pathog. 2016 Feb;91:46-53. doi: 10.1016/j.micpath.2015.11.025. Epub 2015 Nov 30.

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