Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01247)
MIC Name Streptococcus dysgalactiae (firmicutes)
MIC Synonyms Streptococcus pseudogalactiae
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus dysgalactiae
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 2179445
Description Streptococcus dysgalactiae is a facultative anaerobic, Gram positive, beta-haemolytic, coccal bacterium belonging to the family Streptococcaceae. It is capable of infecting both humans and animals, but is most frequently encountered as a commensal of the alimentary tract, genital tract, or less commonly, as a part of the skin flora. The clinical manifestations in human disease range from superficial skin-infections and tonsillitis, to severe necrotising fasciitis and bacteraemia.
External Links Taxonomy ID
1334
Genome Assembly ID
ASM869372v1
GOLD Organism ID
Go0005557
Disease Relevance
          Sepsis  [ICD-11: 1G41]
             Description Streptococcus dysgalactiae was associated with septicaemia. [1]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description The highest IL-10 level contributes to macrophages activation or internalization of Streptococcus dysgalactiae mice. [2]
          Interleukin-17A
             HIF ID HIFM0134 HIF Info       Class Cytokine (Cyt)
             Description High level of IL-17A was detected in CD4(+) T-cells in subjects with Streptococcus dysgalactiae injection. [2]
          Interferon-4
             HIF ID HIFM0149 HIF Info       Class Cytokine (Cyt)
             Description The IL-4 expression was protective immunity against Streptococcus dysgalactiae. [2]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The GapC protein is highly conserved surface dehydrogenase among Streptococcus dysgalactiae (S. dysgalactiae) and is shown to be involved in bacterial virulence. High levels of IFN-Gamma and IL-17A, as well as moderate levels of IL-10 and IL-4 were detected in CD4(+) T-cells isolated from both GapC and peptide-immunized mice in vivo, suggesting that GapC63-77 and GapC96-110 preferentially elicited polarized Th1/Th17-type responses. [2]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Immunizationof GapC protein can induce specific CD4(+) T-cell immune responses and protect against Streptococcus dysgalactiae infection. [2]
Environmental Factor(s)
             Disbiome ID
      62
             gutMDisorder ID
      gm0624
References
1 Omphalitis, urachocystitis and septicemia by Streptococcus dysgalactiae in a southern right whale calf Eubalaena australis, Brazil. Dis Aquat Organ. 2018 Nov 20;131(3):227-232. doi: 10.3354/dao03293.
2 Identification and characterization of CD4+ T-cell epitopes on GapC protein of Streptococcus dysgalactiae. Microb Pathog. 2016 Feb;91:46-53. doi: 10.1016/j.micpath.2015.11.025. Epub 2015 Nov 30.

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