Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0134)
HIF Name
Interleukin-17A
HIF Synonym(s)
interleukin 17A, IL17A, IL17, CTLA8, IL-17, CTLA-8
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description Interleukin 17A (IL-17A) is disulfide-linked homodimeric cytokine of 155 amino acids (molecular weight 35kDa) and a member of an IL-17 family of related cytokines (IL-17B through IL-17F). [1]
Pfam Interleukin-17 (PF06083 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
IL-17 signaling pathway (hsa04657 )
Inflammatory bowel disease (IBD) (hsa05321 )
Rheumatoid arthritis (hsa05323 )
Th17 cell differentiation (hsa04659 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL17_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Actinobacillus pleuropneumoniae (gamma-proteobacteria) MIC00026
             Description Messenger RNA of IL-17A are suitable to characterize the immunological behavior of the Actinobacillus pleuropneumoniae harbouring tissue environment. [2]
         Bacillus firmus (firmicutes) MIC00127
             Description Bacilli is associated with IL-17 expression. [3]
         Bacteroides fragilis (CFB bacteria) MIC00158
             Description Bacteroides fragilis induced infiltration of the colonic lamina propria with IL-17-producing CD3+CD4+ T-cells. [4]
         Brucella canis (alpha-proteobacteria) MIC00269
             Description Brucella canis induced Th1/Th17 responses, with increased CD4+ T cells producing IL-17A simultaneously. [5]
         Candida albicans (budding yeasts) MIC00317
             Description Candidalysin production by Candida albicans hyphae is the triggering factor for innate IL-17 production in the murine model of OPC. [6]
         Clostridium butyricum (firmicutes) MIC00388
             Description Clostridium butyricum CGMCC0313.1 is associated with IL-17A expression. [7]
         Clostridium leptum (firmicutes) MIC00402
             Description Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th17 cell responses,which were characterized by IL-17A production. [8]
         Corynebacterium accolens (actinobacteria) MIC00448
             Description TCRlow cells actively released IL-17A after Corynebacterium accolens infection(P < 0.01). [9]
         Deltaproteobacteria (delta-proteobacteria) MIC00480
             Description Deltaproteobacteria has associations with the IL-17(p = 0.685;R2 = 0.034)in the adipose tissue. [10]
         Granulicatella adiacens (firmicutes) MIC00645
             Description Granulicatella is positive correlation with IL-17A expression. [11]
         Helicobacter acinonychis (epsilon-proteobacteria) MIC00662
             Description Helicobacter acinonychis activated Th17 cells with consequent production of IL-17. [12]
         Klebsiella pneumoniae (enterobacteria) MIC01405
             Description In antibiotic-treated mice there was significantly less intrapulmonary IL-17A produced (p<0.01)in response to infection with Klebsiella pneumoniae. [13]
         Lactococcus lactis (firmicutes) MIC00745
             Description Lactococcus lactis could increase IL-17 expression. [14]
         Parabacteroides goldsteinii (CFB bacteria) MIC00950
             Description Parabacteroides goldsteinii exerts anti-inflammatory effects in the colon with reduction of tumor necrosis factor-alpha (TNFa) production in macrophages and IL-17 expression in colonic tissue. [15]
         Prevotella copri (CFB bacteria) MIC01010
             Description The magnitude of Prevotella copri IgA antibodies has strong positive correlations IL-17A expression. [16]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description Salmonella typhimurium is associated with IL-17 expression. [17]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Staphylococcus aureus specific Th17 cells initially produced the IL-17. [18]
         Staphylococcus xylosus (firmicutes) MIC01227
             Description Staphylococcus xylosus could increase the IL-17A expression. [19]
         Streptococcus dysgalactiae (firmicutes) MIC01247
             Description High level of IL-17A was detected in CD4(+) T-cells in subjects with Streptococcus dysgalactiae injection. [20]
         Yersinia pestis (enterobacteria) MIC01401
             Description Bone marrowderived neutrophils transferred to IL-17A KO mice after 20 days could mitigate the severe inflammatory injuries challenged with Yersinia pestis(p<0.001). [21]
References
1 Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammation.Ann Rheum Dis. 2018 Apr;77(4):523-532. doi: 10.1136/annrheumdis-2017-212127. Epub 2017 Dec 23.
2 Actinobacillus pleuropneumoniae triggers IL-10 expression in tonsils to mediate colonisation and persistence of infection in pigs. Vet Immunol Immunopathol. 2018 Nov;205:17-23. doi: 10.1016/j.vetimm.2018.10.008. Epub 2018 Oct 22.
3 Cording Mycobacterium tuberculosis Bacilli Have a Key Role in the Progression towards Active Tuberculosis, Which is Stopped by Previous Immune Response. Microorganisms. 2020 Feb 8;8(2):228. doi: 10.3390/microorganisms8020228.
4 Bacteroides spp. and diarrhea. Curr Opin Infect Dis. 2010 Oct;23(5):470-4. doi: 10.1097/QCO.0b013e32833da1eb.
5 Brucella canis induces canine CD4(+) T cells multi-cytokine Th1/Th17 production via dendritic cell activation. Comp Immunol Microbiol Infect Dis. 2019 Feb;62:68-75. doi: 10.1016/j.cimid.2018.11.017. Epub 2018 Nov 30.
6 Candida albicans-epithelial interactions and induction of mucosal innate immunity. Curr Opin Microbiol. 2017 Dec;40:104-112. doi: 10.1016/j.mib.2017.10.030. Epub 2017 Nov 17.
7 Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
8 Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
9 Contextual control of skin immunity and inflammation by Corynebacterium. J Exp Med. 2018 Mar 5;215(3):785-799. doi: 10.1084/jem.20171079. Epub 2018 Jan 30.
10 Gut Dysbiosis and Adaptive Immune Response in Diet-induced Obesity vs. Systemic Inflammation. Front Microbiol. 2017 Jun 22;8:1157. doi: 10.3389/fmicb.2017.01157. eCollection 2017.
11 The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients. Scand J Immunol. 2019 Sep;90(3):e12799. doi: 10.1111/sji.12799. Epub 2019 Jul 8.
12 Recombinant Bacillus subtilis Spores Elicit Th1/Th17-Polarized Immune Response in a Murine Model of Helicobacter pylori Vaccination. Mol Biotechnol. 2015 Aug;57(8):685-91. doi: 10.1007/s12033-015-9859-0.
13 The microbiota protects against respiratory infection via GM-CSF signaling. Nat Commun. 2017 Nov 15;8(1):1512. doi: 10.1038/s41467-017-01803-x.
14 Production and delivery of Helicobacter pylori NapA in Lactococcus lactis and its protective efficacy and immune modulatory activity. Sci Rep. 2018 Apr 24;8(1):6435. doi: 10.1038/s41598-018-24879-x.
15 Altered Gut Microbiota Composition and Immune Response in Experimental Steatohepatitis Mouse Models. Dig Dis Sci. 2017 Feb;62(2):396-406. doi: 10.1007/s10620-016-4393-x. Epub 2016 Dec 2.
16 Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May;69(5):964-975. doi: 10.1002/art.40003. Epub 2017 Apr 7.
17 Salmonella Typhimurium, the major causative agent of foodborne illness inactivated by a phage lysis system provides effective protection against lethal challenge by induction of robust cell-mediated immune responses and activation of dendritic cells. Vet Res. 2017 Oct 25;48(1):66. doi: 10.1186/s13567-017-0474-x.
18 Immune control of Staphylococcus aureus - regulation and counter-regulation of the adaptive immune response. Int J Med Microbiol. 2014 Mar;304(2):204-14. doi: 10.1016/j.ijmm.2013.11.008. Epub 2013 Dec 1.
19 The resident pathobiont Staphylococcus xylosus in Nfkbiz-deficient skin accelerates spontaneous skin inflammation. Sci Rep. 2017 Jul 24;7(1):6348. doi: 10.1038/s41598-017-05740-z.
20 Identification and characterization of CD4+ T-cell epitopes on GapC protein of Streptococcus dysgalactiae. Microb Pathog. 2016 Feb;91:46-53. doi: 10.1016/j.micpath.2015.11.025. Epub 2015 Nov 30.
21 Immunology of Yersinia pestis Infection. Adv Exp Med Biol. 2016;918:273-292. doi: 10.1007/978-94-024-0890-4_10.

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