General Information of MIC (ID: MIC00026)
MIC Name	Actinobacillus pleuropneumoniae (gamma-proteobacteria)
MIC Synonyms	Haemophilus pleuropneumoniae
Body Site	Lung
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Pasteurellales Family: Pasteurellaceae Genus: Actinobacillus Species: Actinobacillus pleuropneumoniae
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Saccharolytic; Fermentative; Utilize hydrogen as energy source
Gram	Negative
Genome Size (bp)	2264279
No. of Coding Genes	2155
No. of Non-Coding Genes	53
No. of Small Non-Coding Genes	53
No. of Gene Transcripts	2208
No. of Base Pairs	2264279
Description	Actinobacillus pleuropneumoniae, is a Gram-negative, facultative anaerobic, respiratory pathogen.
External Links	Taxonomy ID	715
	Genome Assembly ID	ASM81752v1
	GOLD Organism ID	Go0520899

Host Genetic Factors (HGFs)
hsa-let-7f-5p
HGF ID	HGF0297	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-15a-5p was up-regulated in response to Actinobacillus pleuropneumoniae infection.				[1]
hsa-miR-451a
HGF ID	HGF0129	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-451a was down-regulated in response to Actinobacillus pleuropneumoniae infection.				[1]
mmu-miR-664-5p
HGF ID	HGF0019	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	The expression of miR-664-5p was up-regulated in response to Actinobacillus pleuropneumoniae infection.				[1]

Host Immune Factors (HIFs)
Interferon-10
HIF ID	HIFM0128	HIF Info	Class	Cytokine (Cyt)
Description	The Actinobacillus pleuropneumoniae presence in the tonsils could elicite an increased IL-10 expression.				[2]
Interleukin-17A
HIF ID	HIFM0134	HIF Info	Class	Cytokine (Cyt)
Description	Messenger RNA of IL-17A are suitable to characterize the immunological behavior of the Actinobacillus pleuropneumoniae harbouring tissue environment.				[2]
Interferon-2
HIF ID	HIFM0141	HIF Info	Class	Cytokine (Cyt)
Description	An attenuated Actinobacillus pleuropneumoniae serovar 1 live vaccine prototype stimulated IL-2 production.				[3]
Neutrophils
HIF ID	HIFC0029	HIF Info	Class	Granulocytes (Gra)
Description	Actinobacillus pleuropneumoniae was eliminated from inflamed lung tissue, which was characterized by an influx of neutrophils.				[2]
Immunoglobulin G2
HIF ID	HIFM0268	HIF Info	Class	Immunoglobulin (Ig)
Description	The abundance of Actinobacillus pleuropneumoniae is associated with IgG2 response.				[4]
Immunoglobulin G1
HIF ID	HIFM0269	HIF Info	Class	Immunoglobulin (Ig)
Description	The abundance of Actinobacillus pleuropneumoniae is associated with IgG1 response.				[4]
T helper type 17 cells
HIF ID	HIFC0080	HIF Info	Class	T cells (TCs)
Description	Actinobacillus pleuropneumoniae-specific Th17 subsets induced the production of IL-17A and IL-10 cytokines.				[2]

Environmental Factor(s)
Disbiome ID			420
gutMDisorder ID			gm0015

References
1	Profiling microRNAs in lung tissue from pigs infected with Actinobacillus pleuropneumoniae. BMC Genomics. 2012 Sep 6;13:459. doi: 10.1186/1471-2164-13-459.
2	Actinobacillus pleuropneumoniae triggers IL-10 expression in tonsils to mediate colonisation and persistence of infection in pigs. Vet Immunol Immunopathol. 2018 Nov;205:17-23. doi: 10.1016/j.vetimm.2018.10.008. Epub 2018 Oct 22.
3	The live attenuated Actinobacillus pleuropneumoniae triple-deletion mutant apxIC apxIIC apxIV-ORF1 strain, SLW05, Immunizes pigs against lethal challenge with Haemophilus parasuis. Clin Vaccine Immunol. 2013 Feb;20(2):134-9. doi: 10.1128/CVI.00458-12. Epub 2012 Dec 5.
4	Anti-haemolysin IgG1 to IgG2 ratios correlate with haemolysin neutralization titres and lung lesion scores in Actinobacillus pleuropneumoniae infected pigs.Vaccine. 1998 Dec;16(20):1971-5. doi: 10.1016/s0264-410x(98)00120-0.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.