General Information of HGF (ID: HGF0297)
HGF Name	hsa-let-7f-5p
HGF Synonym(s)	microRNA let-7f-5p, MIRLET7f-5p, MIRLET7f-5p
Source	Homo sapiens
HGF Classification	Non-coding RNA: Micro (ncRNA-miRNA)
Gene Location	chr9
Gene Start Site	94176353	Gene End Site		94176374
Strand	Forward (+)
Sequence	Click here to download the HGF sequence in FASTA format
External Links
	miRBase ID	MIMAT0000068

Microbe Species (MIC) Regulated by This HGF
Actinobacillus pleuropneumoniae (gamma-proteobacteria)			MIC00026
Description	The expression of miR-15a-5p was up-regulated in response to Actinobacillus pleuropneumoniae infection.				[1]
Aggregatibacter actinomycetemcomitans (gamma-proteobacteria)			MIC00051
Description	The hsa-let-7f targeted suppressors of cytokine signalling 4 (SOCS4) and thrombospondin-1 (TSP-1) during Aggregatibacter actinomycetemcomitans infection.				[2]
Gardnerella vaginalis (actinobacteria)			MIC00626
Description	The level of miR-15a expression was significantly upregulated by Gardnella vaginalis infection (p-value<0.05).				[3]
Mycobacterium sp. (actinobacteria)			MIC00855
Description	The level of miR-15a expression showed significantly upregulated upon Mycobacterium infection (p-value<0.05).				[4]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	The level of let-7f expression was significantly upregulated with Porphyromonas gingivalis infection (p-value<0.05).				[2]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	The let-7f-5p presents in mesenteric lymph nodes in Salmonella Typhimurium infected pigs.				[5]
Salmonella sp. (enterobacteria)			MIC01149
Description	The Salmonella subvert host defences by modulating miR-15a-5p expression.				[6]

References
1	Profiling microRNAs in lung tissue from pigs infected with Actinobacillus pleuropneumoniae. BMC Genomics. 2012 Sep 6;13:459. doi: 10.1186/1471-2164-13-459.
2	MicroRNAs and immunity in periodontal health and disease. Int J Oral Sci. 2018 Aug 6;10(3):24. doi: 10.1038/s41368-018-0025-y.
3	Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. Croston TL, Nayak AP, Lemons AR, Goldsmith WT, Gu JK, Germolec DR, Beezhold DH, Green BJ.. Clin Exp Allergy. 2016 Oct;46(10):1315-27. doi: 10.1111/cea.12783. Epub 2016 Sep 16.
4	Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0002-2019.
5	Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection. Vet Res. 2018 Feb 1;49(1):9. doi: 10.1186/s13567-018-0506-1.
6	Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk. Semin Cell Dev Biol. 2017 May;65:11-19. doi: 10.1016/j.semcdb.2016.06.016. Epub 2016 Jul 2.

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