Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00855)
MIC Name Mycobacterium sp. (actinobacteria)
Body Site Nose
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium sp.
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Description Mycobacterium sp. is a Gram-positive and strict anaerobic bacterium. Mycobacteria belong to the order Actinomycetales that are Gram-positive, acid-fast, pleomorphic, non-motile rods characterized by distinctive cell surface mycolic acid derivatives. They are obligate aerobes.
External Links Taxonomy ID
1785
GOLD Organism ID
Go0005551
Disease Relevance
          Chronic obstructive pulmonary disease  [ICD-11: CA22]
             Description Mycobacterium sp. was associated with pulmonary disease. [1]
Host Genetic Factors (HGFs)
          hsa-let-7f-5p
             HGF ID HGF0297 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-15a expression showed significantly upregulated upon Mycobacterium infection (p-value<0.05). [2]
Host Immune Factors (HIFs)
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description ML1899 conserved in all mycobacterium sp. could up-regulated the expression of IL-6. [3]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description ML1899 conserved in all mycobacterium sp. could up-regulated the expression of IL-8. [3]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description ML1899 conserved in all mycobacterium up-regulated TNF-alpha. [3]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description ML1899 conserved in all mycobacterium sp.up-regulated IFN-gamma. [3]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Mycobacterium sp. up-regulated pro-inflammatory cytokines and chemokine including TNF-, IFN-, IL-6 and IL-8 in macrophages. [3]
Environmental Factor(s)
             Disbiome ID
      839
References
1 Concomitant Presence of Aspergillus Species and Mycobacterium Species in the Respiratory Tract of Patients: Underestimated Co-occurrence. Front Microbiol. 2020 Jan 10;10:2980. doi: 10.3389/fmicb.2019.02980. eCollection 2019.
2 Multifaceted Roles of microRNAs in Host-Bacterial Pathogen Interaction. Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0002-2019.
3 Molecular characterization and immunogenic function of ML1899 (LipG) of Mycobacterium leprae. J Med Microbiol. 2019 Nov;68(11):1629-1640. doi: 10.1099/jmm.0.001080.

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