Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0151)
HIF Name
Interferon-6
HIF Synonym(s)
interleukin 6, IL6, CDF, HGF, HSF, BSF2, IL-6, BSF-2, IFNB2, IFN-beta-2
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine; Growth factor
Description IL-6 which is a key substance that mediates inflammatory response in human body is mainly manifested in regulating physiological activities of various immune cells and controlling immune response. [1]
Pfam Interleukin-6/G-CSF/MGF family (PF00489 )
Pathway AGE-RAGE signaling pathway in diabetic complications (hsa04933 )
African trypanosomiasis (hsa05143 )
Alzheimer disease (hsa05010 )
Amoebiasis (hsa05146 )
Antifolate resistance (hsa01523 )
C-type lectin receptor signaling pathway (hsa04625 )
Cellular senescence (hsa04218 )
Chagas disease (American trypanosomiasis) (hsa05142 )
Cytokine-cytokine receptor interaction (hsa04060 )
Cytosolic DNA-sensing pathway (hsa04623 )
EGFR tyrosine kinase inhibitor resistance (hsa01521 )
Epstein-Barr virus infection (hsa05169 )
FoxO signaling pathway (hsa04068 )
Graft-versus-host disease (hsa05332 )
HIF-1 signaling pathway (hsa04066 )
Hematopoietic cell lineage (hsa04640 )
Hepatitis B (hsa05161 )
Herpes simplex virus 1 infection (hsa05168 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Human cytomegalovirus infection (hsa05163 )
Hypertrophic cardiomyopathy (HCM) (hsa05410 )
IL-17 signaling pathway (hsa04657 )
Inflammatory bowel disease (IBD) (hsa05321 )
Influenza A (hsa05164 )
Insulin resistance (hsa04931 )
Intestinal immune network for IgA production (hsa04672 )
JAK-STAT signaling pathway (hsa04630 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Legionellosis (hsa05134 )
Malaria (hsa05144 )
Measles (hsa05162 )
NOD-like receptor signaling pathway (hsa04621 )
Non-alcoholic fatty liver disease (NAFLD) (hsa04932 )
PI3K-Akt signaling pathway (hsa04151 )
Pathogenic Escherichia coli infection (hsa05130 )
Pathways in cancer (hsa05200 )
Pertussis (hsa05133 )
Prion diseases (hsa05020 )
Rheumatoid arthritis (hsa05323 )
Salmonella infection (hsa05132 )
TNF signaling pathway (hsa04668 )
Th17 cell differentiation (hsa04659 )
Toll-like receptor signaling pathway (hsa04620 )
Transcriptional misregulation in cancer (hsa05202 )
Tuberculosis (hsa05152 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IL6_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Acidobacteria (bacteria) MIC00011
             Description Acidobacteria is associated with IL-6 expression. [2]
         Aggregatibacter aphrophilus (gamma-proteobacteria) MIC00052
             Description Aggregatibacter is associated with IL-6 expression. [3]
         Akkermansia muciniphila (verrucomicrobia) MIC00056
             Description Akkermansia muciniphila induced higher levels of IL-6. [4]
         Alistipes finegoldii (CFB bacteria) MIC00064
             Description Alistipes abundance was negatively correlated with IL-6 expression. [5]
         Aspergillus fumigatus (ascomycetes) MIC00103
             Description Aspergillus fumigatus could reduce gene expression and secretion of IL-6. [6]
         Atopobium vaginae (actinobacteria) MIC00110
             Description IL-6 was secreted by vaginal epithelial cells in response to the activity of Atopobium vaginae. [7]
         Bacillus licheniformis (firmicutes) MIC00132
             Description Bacillus licheniformis could higher expression level of IL-6. [8]
         Bacillus subtilis (firmicutes) MIC00136
             Description Bacillus subtilis could higher expression level of IL-6. [8]
         Bacteroides sp. (CFB bacteria) MIC00176
             Description Bacteroidaceae is associated with IL-6 expression. [9]
         Bacteroides uniformis (CFB bacteria) MIC00184
             Description Bacteroidia is associated with IL-6 expression. [10]
         Bifidobacterium longum (actinobacteria) MIC00232
             Description Bifidobacterium longum stimulated PBMC to produce high levels of IL-6. [11]
         Bifidobacterium pseudolongum (actinobacteria) MIC00220
             Description Bifidobacterium pseudolongum induced less amounts of the proinflammatory cytokines IL-6. [12]
         Brucella suis (alpha-proteobacteria) MIC00275
             Description Brucella suis-infected macrophages produced IL-6. [13]
         Burkholderia cenocepacia (beta-proteobacteria) MIC00280
             Description Burkholderia cenocepacia could increase the expression of IL-6. [14]
         Campylobacter coli (epsilon-proteobacteria) MIC00301
             Description Campylobacter coli could increase the expression of IL-6. [15]
         Campylobacter jejuni (epsilon-proteobacteria) MIC00307
             Description Campylobacter jejuni infection resulted in elevated colonic IL-6 secretion. [16]
         Capnocytophaga ochracea (CFB bacteria) MIC00328
             Description Capnocytophaga ochracea could kill or inactivate enzymatic activity to inhibite the IL-6 expression. [17]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description Chlamydophila pneumoniae could increase the expression of cytokines IL-6. [18]
         Chlorobi (chlorobi) MIC00351
             Description Chlorobi is associated with IL-6 expression. [2]
         Clostridiaceae (firmicutes) MIC00376
             Description Clostridiaceae is associated with IL-6 expression. [19]
         Clostridium sp. (firmicutes) MIC00418
             Description The increased abundance of Clostridium is associated with the increased levels of IL-6 in non-alcoholic fatty liver disease. [20]
         Cyanobacteria (cyanobacteria) MIC00475
             Description Cyanobacteria is associated with IL-6 expression. [21]
         Deltaproteobacteria (delta-proteobacteria) MIC00480
             Description Deltaproteobacteria has associations with the IL-6(p = 490;R2 = 0.070)in the heart tissue. [22]
         Desulfovibrio desulfuricans (delta-proteobacteria) MIC00495
             Description Desulfovibrio desulfuricans-derived lipopolysaccharides stimulated the release of IL-6 from endothelial cell. [23]
         Desulfovibrio sp. (delta-proteobacteria) MIC00493
             Description Desulfovibrio is associated with increased levels of IL-6 in ulcerative colitis patients. [24]
         Dorea sp. (firmicutes) MIC00513
             Description Dorea could cause the increased circulating levels of IL-6. [25]
         Edwardsiella tarda (enterobacteria) MIC00518
             Description Edwardsiella tarda is associated with IL-6 expression. [26]
         Eikenella corrodens (beta-proteobacteria) MIC00525
             Description A slight stimulation of the IL-6 mRNA levels was seen when Eikenella corrodens was separated from KB cells by cell culture inserts. [27]
         Eubacterium limosum (firmicutes) MIC00576
             Description Eubacterium limosum could produce the IL-6 expression. [28]
         Faecalibacterium prausnitzii (firmicutes) MIC00590
             Description Faecalibacterium prausnitzii is associated with IL-6. [29]
         Filifactor alocis (firmicutes) MIC00595
             Description Filifactor alocis elicited a local inflammatory response with neutrophils along with an increase in levels of IL-6. [30]
         Gardnerella vaginalis (actinobacteria) MIC00626
             Description Gardnerella vaginalis induce significantly higher levels of IL-6 than Lactobacillus species. [31]
         Glaesserella parasuis (gamma-proteobacteria) MIC00654
             Description High amounts of IL-6 were producd by CD163+ monocytes during highly virulent Haemophilus parasuis infection. [32]
         Granulicatella adiacens (firmicutes) MIC00645
             Description Granulicatella is positive correlation with IL-6 expression. [33]
         Klebsiella aerogenes (enterobacteria) MIC00530
             Description Enterobacter aerogenes is associated with IL-6 expression. [34]
         Lactobacillus acidophilus (firmicutes) MIC00702
             Description The gene expression of IL6 in IECs could be induced by Lactobacillus acidophilus infection. [35]
         Lactobacillus brevis (firmicutes) MIC00705
             Description Heat-killed Lactobacillus brevis promoted higher gene expression levels of IL-6. [36]
         Lactobacillus crispatus (firmicutes) MIC00710
             Description Lactobacillus crispatus and its supernatant reduced IL-6 production in Chlamydia trachomatis-infected HeLa and J774 cells. [37]
         Lactobacillus gallinarum (firmicutes) MIC00715
             Description Lactobacillus gallinarum WCFS1 induced considerably high amounts of IL-6. [38]
         Lactobacillus jensenii (firmicutes) MIC00720
             Description Lactobacillus jensenii TL2937 was the strain with the highest capacity to down-regulate IL-6 production. [39]
         Lactobacillus kefiranofaciens (firmicutes) MIC00723
             Description Lactobacillus kefiranofaciens could induce the IL-6 expression. [40]
         Lactobacillus plantarum (firmicutes) MIC00730
             Description Lactobacillus plantarum could stimulate the expression of the cytokines IL-6. [41]
         Lactobacillus reuteri (firmicutes) MIC00731
             Description Lactobacillus reuteri treatment could decrease the serum levels of the inflammatory cytokines IL-6. [42]
         Lactobacillus rhamnosus (firmicutes) MIC00732
             Description The combination of iSN34 from Lactobacillus rhamnosus GG could cause synergistic induction (in mouse splenocytes) of IL6. [43]
         Lactobacillus sp. (firmicutes) MIC00701
             Description Lactobacillaceae was negatively correlated with IL-6 expression. [44]
         Leptotrichia goodfellowii (fusobacteria) MIC00762
             Description Leptotrichia could trigger the transcription expression level of IL-6. [45]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with IL-6 expression. [46]
         Methylorubrum extorquens (alpha-proteobacteria) MIC00814
             Description The gene encoding IL-6 was up-regulated during Methylobacterium oryzae infection. [47]
         Mycobacterium sp. (actinobacteria) MIC00855
             Description ML1899 conserved in all mycobacterium sp. could up-regulated the expression of IL-6. [48]
         Mycoplasma genitalium (mycoplasmas) MIC00870
             Description There is no statistically significant differences in the levels of IL-1beta(p>0.05)in the Mollicutes infection with the health. [49]
         Mycoplasma pneumoniae (mycoplasmas) MIC00875
             Description Mycoplasma pneumoniae infection triggers secretion of several proinflammatory cytokines such as IL-6. [50]
         Mycoplasma synoviae (mycoplasmas) MIC00877
             Description Mycoplasma synoviae was able to induce the secretion of IL-6. [51]
         Oceanospirillales (gamma-proteobacteria) MIC00918
             Description Oceanospirillales was negatively correlated with IL-6 expression. [44]
         Oscillibacter valericigenes (firmicutes) MIC01961
             Description Oscillibacter abundance was significantly positively correlated with IL-6. [5]
         Parabacteroides distasonis (CFB bacteria) MIC00949
             Description Parabacteroides distasonis is associated with IL-6 expression. [52]
         Parasutterella excrementihominis (beta-proteobacteria) MIC00963
             Description Parasutterella is associated with increased levels of IL-6 in ulcerative colitis patients. [24]
         Pasteurella multocida (gamma-proteobacteria) MIC00967
             Description Pasteurella multocida was able to induce the subsequent immunomodulatory cytokines such as IL-6. [53]
         Plesiomonas shigelloides (enterobacteria) MIC00994
             Description The biological activities of Plesiomonas shigelloides lipid A can induce the productions of proinflammatory cytokines IL-6. [54]
         Prevotella pallens (CFB bacteria) MIC01022
             Description Prevotella pallens could increase the level of IL-6. [55]
         Propionibacterium sp. (actinobacteria) MIC01030
             Description Propionibacterium acnes could mediate proinflammatory cytokines, such as IL-6. [56]
         Proteobacteria (proteobacteria) MIC01037
             Description Increased abundance of the phyla Proteobacteria is associated with the enriched concentrations of IL-6 in serum. [57]
         Pseudobutyrivibrio (firmicutes) MIC01050
             Description Pseudobutyrivibrio could cause the increased circulating levels of IL-6. [25]
         Rhodococcus hoagii (actinobacteria) MIC01092
             Description Expression of IL-6 was significantly high(p<0.001)in bronchoalveolar macrophages during Rhodococcus equi infection. [58]
         Rickettsia rickettsii (alpha-proteobacteria) MIC01109
             Description Rickettsia rickettsii is associated with IL-6 expression. [59]
         Roseburia intestinalis (firmicutes) MIC01118
             Description Roseburia intestinalis led to a significant reduction in the protein expression of IL-6(P<0.01). [60]
         Ruminococcus gnavus (firmicutes) MIC01137
             Description Ruminococcus gnavus is associated with IL-6 expression. [61]
         Saccharomyces cerevisiae (budding yeasts) MIC01145
             Description Saccharomyces cerevisiae decreased the ETEC-induced IL-6 secretions in IPEC-1 cells. [62]
         Spirochaetes (bacteria) MIC01204
             Description Spirochaetes is associated with IL-6 expression. [63]
         Stenotrophomonas maltophilia (gamma-proteobacteria) MIC01231
             Description The vaccination with rOmpA significantly reduced the levels of IL-6(P<0.01) in BALF after respiratory Stenotrophomonas maltophilia challenge in mice. [64]
         Stenotrophomonas rhizophila (gamma-proteobacteria) MIC01232
             Description The expression levels of IL-6 significantly higher(P<0.0001) in Stenotrophomonas infection. [65]
         Streptococcus cristatus (firmicutes) MIC01246
             Description The RT-PCR confirmed the messenger RNA attenuation of IL-6 by Streptococcus cristatus. [66]
         Streptococcus gallolyticus (firmicutes) MIC01251
             Description Streptococcus gallolyticus infection could increase expression of IL-6. [67]
         Streptococcus gordonii (firmicutes) MIC01252
             Description Following co-stimulation with TNF and Streptococcus gordoniii, the synergistic induction of IL-6 could still be observed. [68]
         Streptococcus mitis (firmicutes) MIC01257
             Description Streptococcus mitis could reduce IL-6 protein levels. [69]
         Streptococcus pyogenes (firmicutes) MIC01267
             Description Streptococcus pyogenes induced inflammatory cytokines production of IL-6. [70]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description Streptococcus thermophilus alters cytokine IL-6 expression levels(25.12 0.61 fold ) of peripheral blood mononuclear cell. [71]
         Streptococcus uberis (firmicutes) MIC01274
             Description The majority of genes with 1.5-fold change within IL-6 Signaling were up-regulated due to inoculated with the 5,000 cfu of Streptococcus uberis intramammary infection. [72]
         Tannerella forsythia (CFB bacteria) MIC01305
             Description Tannerella forsythia may induce pro-inflammatory cytokines such as IL-6. [73]
         Treponema denticola (spirochetes) MIC01322
             Description Treponema denticola could stimulate the production of IL-6. [74]
         Treponema lecithinolyticum (spirochaetes) MIC01323
             Description Treponema lecithinolyticum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-6. [75]
         Treponema maltophilum (spirochaetes) MIC01324
             Description Treponema maltophilum activated human monocytes and PDL cells to induce production of proinflammatory cytokines, such as IL-6. [75]
         Trueperella pyogenes (actinobacteria) MIC01335
             Description Trueperella pyogenes is associated with IL-6 expression. [76]
         Veillonella parvula (firmicutes) MIC01365
             Description Veillonella parvula lipopolysaccharide stimulated IL-6 release in human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner. [77]
         Verrucomicrobia (verrucomicrobia) MIC01368
             Description Verrucomicrobia can induce the IL-6 expression. [78]
         Yersinia enterocolitica (enterobacteria) MIC01398
             Description Yersinia enterocolitica is associated with IL-6 expression. [79]
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