| General Information of MIC (ID: MIC01050) |
| MIC Name |
Pseudobutyrivibrio (firmicutes)
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| Body Site |
Gut
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| Lineage |
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Pseudobutyrivibrio
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| Oxygen Sensitivity |
Obligate anaerobe
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| Microbial Metabolism |
Saccharolytic; Fermentative
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| Gram |
Negative
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| Genome Size (bp) |
2911787
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| Description |
Pseudobutyrivibrio is a Gram-negative, anaerobic and non-spore-forming bacterial genus from the family of Lachnospiraceae
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| External Links |
Taxonomy ID |
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| GOLD Organism ID |
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| Disease Relevance |
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| Chronic kidney disease [ICD-11: GB61] |
| Description |
Pseudobutyrivibrio was negatively correlated with CKD(Chronic kidney disease) severity. |
[1] |
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| Host Genetic Factors (HGFs) |
| rs35197943 |
| HGF ID |
HGF1835 |
HGF Info
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Class |
Single Nucleotide Polymorphism: Intron variant (SNP-IV) |
| Description |
The rs35197943 SNP was significantly associated with the relative abundance of Pseudobutyrivibrio (p-value=2.15E-08). |
[2] |
| rs1826812 |
| HGF ID |
HGF2045 |
HGF Info
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Class |
Single Nucleotide Polymorphism (SNP) |
| Description |
The rs1826812 SNP was significantly associated with the relative abundance of Pseudobutyrivibrio (p-value=5.06E-09). |
[2] |
| rs13100905 |
| HGF ID |
HGF1334 |
HGF Info
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Class |
Single Nucleotide Polymorphism: Intron variant (SNP-IV) |
| Description |
The rs13100905 SNP was significantly associated with the abundance of Pseudobutyrivibrio (p-value=1.73E-08). |
[2] |
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| Host Immune Factors (HIFs) |
| C-C motif chemokine 2 |
| HIF ID |
HIFM0022 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
At the genus level, Pseudobutyrivibrio is associated with the MCP-1 expression. |
[3] |
| Interferon-6 |
| HIF ID |
HIFM0151 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
Pseudobutyrivibrio could cause the increased circulating levels of IL-6. |
[3] |
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| Environmental Factor(s) |
| Disbiome ID |
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| gutMDisorder ID |
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| References |
| 1 |
Gut Microbiota as Diagnostic Tools for Mirroring Disease Progression and Circulating Nephrotoxin Levels in Chronic Kidney Disease: Discovery and Validation Study. Int J Biol Sci. 2020 Jan 1;16(3):420-434. doi: 10.7150/ijbs.37421. eCollection 2020.
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| 2 |
Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
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| 3 |
Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun. 2011 Mar;25(3):397-407. doi: 10.1016/j.bbi.2010.10.023. Epub 2010 Oct 30.
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