Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00350)
MIC Name Chlamydia pneumoniae (chlamydias)
MIC Synonyms Chlamydophila pneumoniae
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Chlamydiae
Class: Chlamydiia
Order: Chlamydiales
Family: Chlamydiaceae
Genus: Chlamydia
Species: Chlamydia pneumoniae
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 1228123
No. of Coding Genes 1123
No. of Non-Coding Genes 49
No. of Small Non-Coding Genes 49
No. of Gene Transcripts 1172
No. of Base Pairs 1228123
Description Chlamydia pneumoniae is a Gram-negative, aerobic, intracellular pathogen. It is typically coccoid or rod-shaped and require growing cells to remain viable.
External Links Taxonomy ID
83558
Genome Assembly ID
CV14
GOLD Organism ID
Go0001308
Disease Relevance
          Abdominal aortic aneurysm  [ICD-11: BD50]
             Description Chlamydia pneumoniae has been linked with abdominal aortic aneurisms. [1]
          Alzheimer disease  [ICD-11: 8A20]
             Description Chlamydia pneumoniae has been linked with Alzheimers disease. [1]
          Asthma  [ICD-11: CA23]
             Description Chlamydia pneumoniae has been linked with valvular asthma. [1]
          Coronary atherosclerosis  [ICD-11: BA80]
             Description Chlamydia pneumoniae has been linked with valvular atherosclerosis. [1]
          Heart valve diseases  [ICD-11: BC0Z]
             Description Chlamydia pneumoniae has been linked with valvular lesions. [1]
          Pneumonia  [ICD-11: CA40]
             Description Chlamydia pneumoniae can cause pneumonia. [1]
Host Genetic Factors (HGFs)
          rs5030737
             HGF ID HGF1526 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs5030737 SNP was associated with the abundance of Chlamydia pneumoniae (p-value<0.05). [2]
          rs1800451
             HGF ID HGF1528 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs1800451 SNP was associated with the abundance of Chlamydia pneumoniae (p-value<0.05). [2]
          rs1800450
             HGF ID HGF1527 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs1800450 SNP was associated with the abundance of Chlamydia pneumoniae (p-value<0.05). [2]
Host Immune Factors (HIFs)
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description Chlamydophila pneumoniae could increase the MCP-1 expression. [3]
          C-X-C motif chemokine 1
             HIF ID HIFM0109 HIF Info       Class Cytokine (Cyt)
             Description Chlamydophila pneumoniae is associated with chemokine C-X-C motif ligand 1 (CXCL1) expression. [3]
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description Chlamydophila pneumoniae could increase the expression of IL-12. [3]
          Interferon-18
             HIF ID HIFM0136 HIF Info       Class Cytokine (Cyt)
             Description The NLRP3 inflammasome can detect cellular stress induced by Chlamydophila pneumoniae infection, resulting in caspase-1 activation and production of IL-18 following priming by the TLR2/MyD88 pathway. [3]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Chlamydophila pneumoniae infection can increase IL-1 levels in the pancreas. [3]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Chlamydophila pneumoniae could increase the expression of cytokines IL-6. [3]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Chlamydophila pneumoniae could increase the expression of IL-8. [3]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Chlamydophila pneumoniae could increase the level of TNF-Alpha. [3]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Chlamydophila pneumoniae could increase the level of IFN-Gamma. [3]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description The titer of Chlamydophila pneumoniaespecific IgE levels in asthmatic patients significantly correlated with asthma severity. [3]
          NACHT, LRR and PYD domains-containing protein 3
             HIF ID HIFM0180 HIF Info       Class Nod-like receptor (NLR)
             Description The NLRP3 inflammasome can detect cellular stress induced by Chlamydophila pneumoniae infection, resulting in caspase-1 activation and production of IL-18 following priming by the TLR2/MyD88 pathway. [3]
          Nucleotide-binding oligomerization domain-containing protein 1
             HIF ID HIFM0184 HIF Info       Class Nod-like receptor (NLR)
             Description Intracellular receptors NOD1,which recognize peptidoglycan components, is important players in the immune response to Chlamydophila pneumoniae. [3]
          Myeloid differentiation primary response 88 signaling pathway
             HIF ID HIFP0026 HIF Info       Class Signaling pathway (SP)
             Description Chlamydophila pneumoniae inflammatory responses are dependent on TLRs and the Myd88-dependent pathway. [3]
          Nucleotide binding oligomerization domain containing 2 signaling pathway
             HIF ID HIFP0029 HIF Info       Class Signaling pathway (SP)
             Description The abundance of Chlamydophila pneumoniae is associated with NOD2 [3]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Chlamydophila pneumoniae is associated with NF-B. [3]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description The activation of CD4+ T cells response is critical to resolve Chlamydophila pneumoniae infection. [3]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description The activation of CD8+ T cells response is critical to resolve Chlamydophila pneumoniae infection. [3]
          Normal T-cell expressed and secreted
             HIF ID HIFC0079 HIF Info       Class T cells (TCs)
             Description Chlamydophila pneumoniae could increase normal T-cell expressed and secreted (RANTES). [3]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description The NLRP3 inflammasome can detect cellular stress induced by Chlamydophila pneumoniae infection, resulting in caspase-1 activation and production of IL-18 following priming by the TLR2/MyD88 pathway. [3]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description Chlamydophila pneumoniae infection of primary aortic endothelial cells results in enhanced production of granulocyte macrophage colony stimulating factor (GM-CSF) in a TLR4- dependent manner that may promote enhanced DC proliferation within the atherosclerotic lesions. [3]
Environmental Factor(s)
             Disbiome ID
      508
References
1 Evolution to a chronic disease niche correlates with increased sensitivity to tryptophan availability for the obligate intracellular bacterium Chlamydia pneumoniae. J Bacteriol. 2014 Jun;196(11):1915-24. doi: 10.1128/JB.01476-14. Epub 2014 Mar 28.
2 The association of mannose binding lectin genotype and immune response to Chlamydia pneumoniae: The Strong Heart Study.PLoS One. 2019 Jan 10;14(1):e0210640. doi: 10.1371/journal.pone.0210640. eCollection 2019.
3 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.

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