Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0180)
HIF Name
NACHT, LRR and PYD domains-containing protein 3
HIF Synonym(s)
NLR family pyrin domain containing 3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCAS1, FCU, KEFH, MWS, NALP3, PYPAF1
HIF Classification
Nod-like receptor (NLR)
Molecular Function
Activator
Description NLRP3 is a member of the Nucleotide oligomerization domain (NOD)-like receptor (NLR)family NLRP. [1]
Pfam Fish-specific NACHT associated domain (PF14484 )
Leucine Rich repeat (PF13516 )
NACHT domain (PF05729 )
NLRC4 helical domain HD2 (PF17776 )
NOD2 winged helix domain (PF17779 )
PAAD/DAPIN/Pyrin domain (PF02758 )
Pathway C-type lectin receptor signaling pathway (hsa04625 )
Influenza A (hsa05164 )
NOD-like receptor signaling pathway (hsa04621 )
Necroptosis (hsa04217 )
Pathogenic Escherichia coli infection (hsa05130 )
Pertussis (hsa05133 )
Salmonella infection (hsa05132 )
Shigellosis (hsa05131 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
NLRP3_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description The NLRP3 inflammasome can detect cellular stress induced by Chlamydophila pneumoniae infection, resulting in caspase-1 activation and production of IL-18 following priming by the TLR2/MyD88 pathway. [2]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with NALP3 activation. [3]
         Mycoplasma pneumoniae (mycoplasmas) MIC00875
             Description NLRP3 is a critical regulator of inflammation and innate immune cell response during Mycoplasma pneumoniae Infection. [4]
         Propionibacterium sp. (actinobacteria) MIC01030
             Description Propionibacterium acnes could mediate proinflammatory cytokines, such as NLRP3. [5]
         Treponema pallidum (spirochaetes) MIC01325
             Description Treponema pallidum-induced macrophages induced NLRP3-dependent IL-1beta secretion. [6]
References
1 Function of Nod-like receptors in microbial recognition and host defense.Immunol Rev. 2009 Jan;227(1):106-28. doi: 10.1111/j.1600-065X.2008.00734.x.
2 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
3 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
4 NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection. Infect Immun. 2017 Dec 19;86(1):e00548-17. doi: 10.1128/IAI.00548-17. Print 2018 Jan.
5 Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol. Int J Mol Sci. 2019 Jul 17;20(14):3510. doi: 10.3390/ijms20143510.
6 The P2X7 receptor mediates NLRP3-dependent IL-1 secretion and promotes phagocytosis in the macrophage response to Treponema pallidum. Int Immunopharmacol. 2020 Mar 6;82:106344. doi: 10.1016/j.intimp.2020.106344. Online ahead of print.

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