Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01030)
MIC Name Propionibacterium sp. (actinobacteria)
Body Site Blood
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Propionibacteriales
Family: Propionibacteriaceae
Genus: Propionibacterium
Species: Propionibacterium sp.
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Description Propionibacterium is a Gram-positive, anaerobic, rod-shaped genus of bacteria named for their unique metabolism. Its members are primarily facultative parasites and commensals of humans and other animals, living in and around the sweat glands, sebaceous glands, and other areas of the skin. They are virtually ubiquitous and do not cause problems for most people, but propionibacteria have been implicated in acne and other skin conditions.
External Links Taxonomy ID
1977903
GOLD Organism ID
Go0533388
Disease Relevance
          Chronic rhinosinusitis  [ICD-11: CA0A]
             Description Propionibacterium was associated with chronic rhinosinusitis. [1]
          Peptic ulcer  [ICD-11: DA61]
             Description Elevated content of Propionibacterium occured in peptic ulcer disorders. [2]
Host Immune Factors (HIFs)
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description PJS(Propionibacterium freudenreicbii spp.sbermanii Js) could lowered intestinal immunoreactivity of TNF-alpha. [3]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Propionibacterium acnes could mediate proinflammatory cytokines, such as IL-6. [4]
          Mast cells
             HIF ID HIFC0022 HIF Info       Class Granulocytes (Gra)
             Description Propionibacterium freudenreichii spp. shermanii JS infection exhibited significantly low numbers of intestinal mast cells. [3]
          NACHT, LRR and PYD domains-containing protein 3
             HIF ID HIFM0180 HIF Info       Class Nod-like receptor (NLR)
             Description Propionibacterium acnes could mediate proinflammatory cytokines, such as NLRP3. [4]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Propionibacterium acnes is recognized by the toll-like receptors TLR2 and TLR4 and triggers the expression of inflammatory mediators through activating MAP kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB). [4]
Environmental Factor(s)
             Disbiome ID
      101
             gutMDisorder ID
      gm0543
References
1 Next Generation Sequencing and the Microbiome of Chronic Rhinosinusitis: A Primer for Clinicians and Review of Current Research, Its Limitations, and Future Directions. Ann Otol Rhinol Laryngol. 2016 Aug;125(8):613-21. doi: 10.1177/0003489416641429. Epub 2016 Apr 7.
2 Profiles of Microbial Fatty Acids in the Human Metabolome are Disease-Specific. Front Microbiol. 2011 Jan 20;1:148. doi: 10.3389/fmicb.2010.00148. eCollection 2010.
3 Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet. Br J Nutr. 2013 Jul 14;110(1):77-85. doi: 10.1017/S0007114512004801. Epub 2012 Dec 5.
4 Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol. Int J Mol Sci. 2019 Jul 17;20(14):3510. doi: 10.3390/ijms20143510.

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