General Information of HIF (ID: HIFC0022)
HIF Name	Mast cells
HIF Synonym(s)	mast cell, Mast cells
HIF Classification	Granulocytes (Gra)
Description	Mast cells are long-lived tissue-resident cells with an important role in many inflammatory settings including host defence to parasitic infection and in allergic reactions. Mast cells are located at the boundaries between tissues and the external environment, for example, at mucosal surfaces of the gut and lungs, in the skin and around blood vessels.				[1]

Microbe Species (MIC) Regulated by This HIF
Clostridioides difficile (firmicutes)			MIC00396
Description	Mast cells increase activation by Clostridium difficile toxins.				[2]
Leuconostoc citreum (firmicutes)			MIC00764
Description	Leuconostoc citreum is associated with mast cells response.				[3]
Propionibacterium sp. (actinobacteria)			MIC01030
Description	Propionibacterium freudenreichii spp. shermanii JS infection exhibited significantly low numbers of intestinal mast cells.				[4]

References
1	Mast cells.Physiol Rev. 1997 Oct;77(4):1033-79. doi: 10.1152/physrev.1997.77.4.1033.
2	Immune responses to Clostridium difficile infection.Trends Mol Med. 2012 Nov;18(11):658-66. doi: 10.1016/j.molmed.2012.09.005. Epub 2012 Oct 16.
3	Leuconostoc citreum isolated from kimchi suppresses the development of collagen-induced arthritis in DBA/1 mice. Min-SungKwon. Journal of Functional Foods. 63, 103579. doi:10.1016/j.jff.2019.103579
4	Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet. Br J Nutr. 2013 Jul 14;110(1):77-85. doi: 10.1017/S0007114512004801. Epub 2012 Dec 5.

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