Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0028)
HIF Name
Nuclear factor kappa B signaling pathway
HIF Synonym(s)
NF-kappaB signaling, NF-kB signaling pathway
HIF Classification
Signaling pathway (SP)
Description The IKK/NF-kB signaling pathway is key to the linking of metabolism, inflammation, and insulin action. [1]
Microbe Species (MIC) Regulated by This HIF
         Achromobacter piechaudii (beta-proteobacteria) MIC01438
             Description There is a slight capability to lower the NF-kB activation upon stimulation by toxic LPS from Acetobacter pasteurianus CIP103108. [2]
         Alphaproteobacteria (alpha-proteobacteria) MIC00070
             Description Dietary -glucan supplementation has a positive impact on immune responses of the intestine of sea cucumber by activating NF-B signaling pathway, probably through modulating the balance of intestinal microbiota(Alphaproteobacteria). [3]
         Atopobium vaginae (actinobacteria) MIC00110
             Description The abundance of Atopobium vaginae is associated with the NFkappaB signaling pathway. [4]
         Borrelia recurrentis (spirochaetes) MIC00255
             Description Borrelia recurrentis Vmp could rapidly stimulate nuclear translocation of NF-B. [5]
         Butyricimonas (CFB bacteria) MIC00294
             Description Decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. [6]
         Campylobacter concisus (epsilon-proteobacteria) MIC00302
             Description Global profiling of the transcriptome revealed the significant regulation of a total of 8, 343 transcripts upon infection with Campylobacter concisus, which included the activation of key inflammatory pathways involving CREB1, NF-kappaB, STAT, and interferon regulatory factor signaling. [7]
         Candida albicans (budding yeasts) MIC00317
             Description Candida albicans yeast cells are recognized by oral epithelial cells (in the TR146 cell line) and induce three signalling pathways within 15 min; the nuclear factor-kappaB (NF-kappaB) pathway, the phosphatidylinositol-4,5-bisphosphate 3-kinase (Pi3K), and all three mitogen-activated protein kinase (MAPK) pathways (p38, JNK (c-Jun N-terminal kinase) and ERK1/2 (extracellular signal-regulated protein kinase)). [8]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description At the species level, Chlamydophila pneumoniae is associated with NF-B. [9]
         Clostridioides difficile (firmicutes) MIC00396
             Description Toxins are a major Clostridium difficile virulence factor, they could disrupt the actin cytoskeleton and activate the inflammasome and NFkappaB-mediated pathways that lead to proinflammatory cytokine and chemokine production. [10]
         Gammaproteobacteria (gamma-proteobacteria) MIC00624
             Description At the class level, Gammaproteobacteria is associated with NF-B. [11]
         Klebsiella pneumoniae (enterobacteria) MIC01405
             Description At the species level, Klebsiella pneumoniae is associated with NF-B. [12]
         Lactobacillus acidophilus (firmicutes) MIC00702
             Description At the species level, Lactobacillus acidophilus is associated with NF-B. [13]
         Lactobacillus jensenii (firmicutes) MIC00720
             Description Lactobacillus jensenii TL2937 could inhibite NF-B signaling pathways. [14]
         Lactobacillus plantarum (firmicutes) MIC00730
             Description Heat-killed Lactobacillus plantarum MYL26 and bacterial cell wall extracts are able to reduce LPS-induced inflammation by impairing toll-like receptor 4 (TLR4)-nuclear factor kappaB (NF-kappaB) signal transduction in vitro. [15]
         Leuconostoc mesenteroides (firmicutes) MIC00766
             Description Leuconostoc mesenteroides is associated with the activation of NF-kappaB signaling. [16]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with NF-B induction. [17]
         Mycoplasma pneumoniae (mycoplasmas) MIC00875
             Description Proinflammatory gene upregulation during Mycoplasma pneumoniae infection is mediated by the MyD88/NF-kappaB pathway. [18]
         Mycoplasma synoviae (mycoplasmas) MIC00877
             Description Viable Mycoplasma synoviae cells could induce elevated levels of NF-B transcripts in HD11 cells. [19]
         Peptostreptococcus anaerobius (firmicutes) MIC00980
             Description Peptostreptococcus anaerobius is associated with the activation of NF-kappaB. [20]
         Propionibacterium sp. (actinobacteria) MIC01030
             Description Propionibacterium acnes is recognized by the toll-like receptors TLR2 and TLR4 and triggers the expression of inflammatory mediators through activating MAP kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB). [21]
         Rothia dentocariosa (actinobacteria) MIC01124
             Description The Rothia dentocariosa-infected cells could induce NF-kappaB activation in the transfected HEK293 cells in a dose-dependent manner. [22]
         Streptococcus cristatus (firmicutes) MIC01246
             Description Streptococcus cristatus attenuates Fusobacterium nucleatum-induced cytokine expression by influencing pathways converging on nuclear factor-kappaB. [23]
         Streptococcus salivarius (firmicutes) MIC01268
             Description live Streptococcus salivarius strains could inhibite the activation of the NF-kappaB pathway. [24]
         Streptomyces griseus (actinobacteria) MIC01280
             Description Streptomyces griseus (S.griseus) chitinase-induced IL-8 expression is regulated by the activation of NF-kB in human airway epithelial cells. [25]
         Treponema denticola (spirochetes) MIC01322
             Description Treponema denticola could trigger activation of NF-B. [26]
         Treponema lecithinolyticum (spirochaetes) MIC01323
             Description The abundance of Treponema lecithinolyticum is associated with NF-B activation. [27]
         Treponema maltophilum (spirochaetes) MIC01324
             Description The abundance of Treponema maltophilum is associated with NF-B activation. [27]
         Yersinia pestis (enterobacteria) MIC01401
             Description LPS in Yersinia pestis upregulates cell survival genes and inflammatory cytokine production controlled by MAPK and NF-kB. [28]
References
1 The nuclear factor NF-kappaB pathway in inflammation.Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651. doi: 10.1101/cshperspect.a001651. Epub 2009 Oct 7.
2 Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP103108. Int J Biol Macromol. 2018 Nov;119:1027-1035. doi: 10.1016/j.ijbiomac.2018.08.035. Epub 2018 Aug 8.
3 Intestinal microbiota and immune related genes in sea cucumber (Apostichopus japonicus) response to dietary -glucan supplementation. Biochem Biophys Res Commun. 2015 Feb 27;458(1):98-103. doi: 10.1016/j.bbrc.2015.01.074. Epub 2015 Jan 29.
4 Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis. Microbes Infect. 2008 Apr;10(4):439-46. doi: 10.1016/j.micinf.2008.01.004. Epub 2008 Jan 12.
5 Direct evidence for involvement of NF-kappaB in transcriptional activation of tumor necrosis factor by a spirochetal lipoprotein. Infect Immun. 2000 Sep;68(9):5447-9. doi: 10.1128/iai.68.9.5447-5449.2000.
6 Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015.
7 Transcriptomic and proteomic analyses reveal key innate immune signatures in the host response to the gastrointestinal pathogen Campylobacter concisus. Infect Immun. 2015 Feb;83(2):832-45. doi: 10.1128/IAI.03012-14. Epub 2014 Dec 8.
8 Candida albicans-epithelial interactions and induction of mucosal innate immunity. Curr Opin Microbiol. 2017 Dec;40:104-112. doi: 10.1016/j.mib.2017.10.030. Epub 2017 Nov 17.
9 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
10 Immune responses to Clostridium difficile infection.Trends Mol Med. 2012 Nov;18(11):658-66. doi: 10.1016/j.molmed.2012.09.005. Epub 2012 Oct 16.
11 IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome. J Immunol. 2019 Feb 1;202(3):920-930. doi: 10.4049/jimmunol.1800226. Epub 2018 Dec 28.
12 Pseudomonas aeruginosa and Klebsiella pneumoniae Adaptation to Innate Immune Clearance Mechanisms in the Lung. J Innate Immun. 2018;10(5-6):442-454. doi: 10.1159/000487515. Epub 2018 Apr 4.
13 Synbiotic Effects of the Dietary Fiber Long-Chain Inulin and Probiotic Lactobacillus acidophilus W37 Can be Caused by Direct, Synergistic Stimulation of Immune Toll-Like Receptors and Dendritic Cells. Mol Nutr Food Res. 2018 Jun 14;62(15):e1800251. doi: 10.1002/mnfr.201800251. Online ahead of print.
14 Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937. Front Immunol. 2014 Jan 14;4:512. doi: 10.3389/fimmu.2013.00512. eCollection 2014 Jan 14.
15 Short communication: Complete genome sequence of Lactobacillus plantarum J26, a probiotic strain with immunomodulatory activity. J Dairy Sci. 2019 Dec;102(12):10838-10844. doi: 10.3168/jds.2019-16593. Epub 2019 Sep 20.
16 Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK. Cytokine. 2009 May;46(2):283-9. doi: 10.1016/j.cyto.2009.02.005. Epub 2009 Mar 18.
17 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
18 NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection. Infect Immun. 2017 Dec 19;86(1):e00548-17. doi: 10.1128/IAI.00548-17. Print 2018 Jan.
19 Diacylated lipopeptide from Mycoplasma synoviae mediates TLR15 induced innate immune responses. Vet Res. 2013 Oct 17;44(1):99. doi: 10.1186/1297-9716-44-99.
20 Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity. Nat Microbiol. 2019 Dec;4(12):2319-2330. doi: 10.1038/s41564-019-0541-3. Epub 2019 Sep 9.
21 Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol. Int J Mol Sci. 2019 Jul 17;20(14):3510. doi: 10.3390/ijms20143510.
22 Rothia dentocariosa induces TNF-alpha production in a TLR2-dependent manner. Pathog Dis. 2014 Jun;71(1):65-8. doi: 10.1111/2049-632X.12115. Epub 2013 Dec 16.
23 Streptococcus cristatus attenuates Fusobacterium nucleatum-induced cytokine expression by influencing pathways converging on nuclear factor-B. Mol Oral Microbiol. 2011 Apr;26(2):150-63. doi: 10.1111/j.2041-1014.2010.00600.x. Epub 2011 Jan 27.
24 Anti-inflammatory properties of Streptococcus salivarius, a commensal bacterium of the oral cavity and digestive tract. Appl Environ Microbiol. 2014 Feb;80(3):928-34. doi: 10.1128/AEM.03133-13. Epub 2013 Nov 22.
25 Chitinase induce the release of IL-8 in human airway epithelial cells, via Ca2+-dependent PKC and ERK pathways. Scand J Immunol. 2010 Jul;72(1):15-21. doi: 10.1111/j.1365-3083.2010.02404.x.
26 Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2. Infect Immun. 2017 Dec 19;86(1):e00573-17. doi: 10.1128/IAI.00573-17. Print 2018 Jan.
27 Upregulation of intercellular adhesion molecule 1 and proinflammatory cytokines by the major surface proteins of Treponema maltophilum and Treponema lecithinolyticum, the phylogenetic group IV oral spirochetes associated with periodontitis and endodontic infections. Infect Immun. 2005 Jan;73(1):268-76. doi: 10.1128/IAI.73.1.268-276.2005.
28 Immunology of Yersinia pestis Infection. Adv Exp Med Biol. 2016;918:273-292. doi: 10.1007/978-94-024-0890-4_10.

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