Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00294)
MIC Name Butyricimonas (CFB bacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Odoribacteraceae
Genus: Butyricimonas
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Description Butyricimonas is a bacterial genus under Porphyromonadaceae family. Butyricimonas is a butyric acid-producing bacterium in the family 'Porphyromonadaceae' originally isolated from rat faeces. This genus contains microbial species that can reside in the human gastrointestinal tract.
External Links Taxonomy ID
574697
GOLD Organism ID
Go0544618
Disease Relevance
          Multiple sclerosis  [ICD-11: 8A40]
             Description Butyricimonas was decreased in the untreated multiple sclerosis patients as compared with healthy participants [1]
Host Immune Factors (HIFs)
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description The abundance of Butyricimonas decreases in dendritic cells. [2]
          Monocytes
             HIF ID HIFC0024 HIF Info       Class Monocytes (Mono)
             Description Decreases in Butyricimonas correlated with variations in interferon signalling and NF-kB signalling pathways in circulating monocytes. [2]
          Interferon signaling pathway
             HIF ID HIFP0017 HIF Info       Class Signaling pathway (SP)
             Description Decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. [2]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes. [2]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Butyricimonas decreases in circulating T cells. [2]
Environmental Factor(s)
             Disbiome ID
      772
             gutMDisorder ID
      gm0136
References
1 Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection. Genome Med. 2016 Apr 28;8(1):49. doi: 10.1186/s13073-016-0301-4.
2 Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015.

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