Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0017)
HIF Name	Interferon signaling pathway
HIF Synonym(s)	interferon signalling, Interferon signaling pathway
HIF Classification	Signaling pathway (SP)
Description	Interferon (IFN) Cell Signaling Pathway. Following viral infection, the human body triggers a complex regulatory system of innate and adaptive immune responses designed to defend against the virus. One of the many responses to the viral invasion is the induction of the pleiotropic cytokines, interferon (IFN) [1].	[1]

Microbe Species (MIC) Regulated by This HIF
Butyricimonas (CFB bacteria)		MIC00294
Description	Decreases in Butyricimonas, and correlate with variations in the expression of genes involved in dendritic cell maturation, interferon signalling and NF-kB signalling pathways in circulating T cells and monocytes.		[2]

References
1	Decoding type I and III interferon signalling during viral infection.Version 2. Nat Microbiol. 2019 Jun;4(6):914-924. doi: 10.1038/s41564-019-0421-x. Epub 2019 Apr 1.
2	Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015.

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