| General Information of MIC (ID: MIC00255) |
| MIC Name |
Borrelia recurrentis (spirochaetes)
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| MIC Synonyms |
Spirochaete recurrentis
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| Body Site |
Blood
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| Lineage |
Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Spirochaetales
Family: Borreliaceae
Genus: Borrelia
Species: Borrelia recurrentis
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| Oxygen Sensitivity |
Aerobe
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| Microbial Metabolism |
Respiration
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| Gram |
Negative
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| Host Relationship |
Pathogen
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| Description |
Borrelia recurrentis is a species of Borrelia, a spirochaete bacterium associated with relapsing fever.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Host Genetic Factors (HGFs) |
| rs41289586 |
| HGF ID |
HGF1927 |
HGF Info
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Class |
Single Nucleotide Polymorphism: Missense variant (SNP-MV) |
| Description |
The rs41289586 SNP was significantly associated with the abundance of Borrelia recurrentis (p-value=7.18E-08). |
[1] |
| rs17850869 |
| HGF ID |
HGF1225 |
HGF Info
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Class |
Single Nucleotide Polymorphism: Synonymous variant (SNP-SV) |
| Description |
The rs17850869 SNP was significantly associated with the abundance of Borrelia recurrentis (p-value=4.17E-09). |
[1] |
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| Host Immune Factors (HIFs) |
| Tumor necrosis factor |
| HIF ID |
HIFM0226 |
HIF Info
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Class |
Cytokine (Cyt) |
| Description |
The abundance of Borrelia recurrentis is associated with TNF. |
[2] |
| Immunoglobulin M |
| HIF ID |
HIFM0266 |
HIF Info
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Class |
Immunoglobulin (Ig) |
| Description |
IgM could provide a component of protective immunity in Borrelia recurrentis infection. |
[3] |
| Nuclear factor kappa B signaling pathway |
| HIF ID |
HIFP0028 |
HIF Info
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Class |
Signaling pathway (SP) |
| Description |
Borrelia recurrentis Vmp could rapidly stimulate nuclear translocation of NF-B. |
[2] |
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| Environmental Factor(s) |
| gutMDisorder ID |
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| References |
| 1 |
A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity.Mol Med. 2015 Feb 23;21(1):26-37. doi: 10.2119/molmed.2014.00219.
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| 2 |
Direct evidence for involvement of NF-kappaB in transcriptional activation of tumor necrosis factor by a spirochetal lipoprotein. Infect Immun. 2000 Sep;68(9):5447-9. doi: 10.1128/iai.68.9.5447-5449.2000.
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| 3 |
IgM in microbial infections: taken for granted. Immunol Lett. 2009 Aug 15;125(2):79-85. doi: 10.1016/j.imlet.2009.06.003. Epub 2009 Jun 17.
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