Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00730)
MIC Name Lactobacillus plantarum (firmicutes)
MIC Synonyms Streptobacterium plantarum
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus plantarum
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 3348624
No. of Coding Genes 3155
No. of Non-Coding Genes 84
No. of Small Non-Coding Genes 84
No. of Gene Transcripts 3239
No. of Base Pairs 3324076
Description Lactobacllus plantarum is a facultative anaerobic, Gram positive, widespread member of the genus Lactobacillus, comonly found in many fermented food products as well as anaerobic plant matter. It is also present in saliva (from which it was first isolated). L.plantarum has one of the largest genomes known among the lactic acid bacteria and is a very flexible and versatile species. Along with promoting normal digestive health, Lactobacillus plantarum has been shown to be an effetive treatment for irritable bowel syndrome, Crohn's disease and colitis.
External Links Taxonomy ID
1590
Genome Assembly ID
ASM73185v1
GOLD Organism ID
Go0005160
Disease Relevance
          Crohn disease  [ICD-11: DD70]
             Description Abincol (Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01), an oral nutraceutical, pragmatic use in patients with chronic intestinal disorders,such as ulcerative colitis and Crohn's disease. [1]
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Lactobacillus plantarum 299v (DSM 9843) provided effective symptom relief, particularly of abdominal pain and bloating, in IBS(Irritable bowel syndrome) patients fulfilling the Rome III criteria. [2]
          Obesity  [ICD-11: 5B81]
             Description Lactobacillus plantarum is downregulated in obesity. [3]
          Vibrio mimicus gastroenteritis  [ICD-11: 1A40]
             Description The colitis triggered by DSS was less severe in the mice that received the L. plantarum treatment, which also diversified the microbe species in the colon [4]
Host Immune Factors (HIFs)
          T-lymphocyte activation antigen CD86
             HIF ID HIFM0055 HIF Info       Class Checkpoint molecule (CM)
             Description The proportions of cells expressing the co-receptors CD86 was associated with the abundance of Lactobacillus plantarum. [5]
          HLA class II histocompatibility antigen, DR alpha chain
             HIF ID HIFM0093 HIF Info       Class Checkpoint molecule (CM)
             Description The Lactobacillus plantarum exopolysaccharide also up-regulated the expression of MHC II and CD86 on DCs surface and promoted T cells to proliferate in vitro. [5]
          C-X-C motif chemokine 9
             HIF ID HIFM0073 HIF Info       Class Cytokine (Cyt)
             Description The cirrhotic complications induced by TAA are through activation of CXCL9 pathway and could be prevented by the early administration of Lactobacillus Plantarum. [6]
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus plantarum could stimulate the expression of the cytokines IL-1alpa. [7]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus plantarum could stimulate the expression of the cytokines IL-1beta. [7]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus plantarum could stimulate the expression of the cytokines IL-6. [7]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Lactobacillus plantarum could upregulate the mRNA expression of proinflammatory cytokines TNF-Alpha. [7]
          CD103+CD11b+ dendritic cells
             HIF ID HIFC0163 HIF Info       Class Dendritic cells (DCs)
             Description The CD103+CD11b+ DCs response is significantly associated with Lactobacillus plantarum infection. [8]
          High affinity immunoglobulin gamma Fc receptor I
             HIF ID HIFM0104 HIF Info       Class Fc Receptor (FCR)
             Description Only monocytes exposed to IFN-I-producing Lactobacillus plantarum showed a very significant reduction in CD64 expression. [9]
          Peripheral blood natural killer cells
             HIF ID HIFC0181 HIF Info       Class Natural killer cells (NKCs)
             Description Peripheral blood NK cells stimulated by Lactobacillus plantarum conferred protection against intestinal epithelial barrier damage. [10]
          Nuclear factor kappa B signaling pathway
             HIF ID HIFP0028 HIF Info       Class Signaling pathway (SP)
             Description Heat-killed Lactobacillus plantarum MYL26 and bacterial cell wall extracts are able to reduce LPS-induced inflammation by impairing toll-like receptor 4 (TLR4)-nuclear factor kappaB (NF-kappaB) signal transduction in vitro. [7]
          Mitogen-activated protein kinase signaling pathway
             HIF ID HIFP0023 HIF Info       Class Signaling pathway (SP)
             Description Lactobacillus plantarum was associated with MAPK signalling pathway. [7]
          Toll like receptor 2 signalling pathway
             HIF ID HIFP0044 HIF Info       Class Signaling pathway (SP)
             Description Lactobacillus plantarum was associated with TLR-2 signalling pathway. [7]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description Lactobacillus plantarum infection showed a Mincle-dependent induction of IL-17 and IL-22 production by CD4+ T cells. [8]
          CD4+FOXP3+ regulatory T cells
             HIF ID HIFC0200 HIF Info       Class T cells (TCs)
             Description Lactobacillus plantarum DSM15313 is related to the increase of CD4+FOXP3+ Treg cells in the MLNs. [11]
          Monocyte differentiation antigen CD14
             HIF ID HIFM0037 HIF Info       Class T-cell receptor (TCR)
             Description Probiotics(Lactobacillus plantarum) can inhibit the binding of lipopolysaccharides to the CD14 receptor. [12]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Lactobacillus plantarum could stimulate the expression of the TLR-2. [7]
Environmental Factor(s)
             Disbiome ID
      342
             gutMDisorder ID
      gm0393
References
1 Abincol(Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, Lactobacillus delbrueckii LDD01), an oral nutraceutical, pragmatic use in patients with chronic intestinal disorders. Acta Biomed. 2019 Jul 10;90(7-S):8-12. doi: 10.23750/abm.v90i7-S.8649.
2 Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome. World J Gastroenterol. 2012 Aug 14;18(30):4012-8. doi: 10.3748/wjg.v18.i30.4012.
3 Intestinal Lactobacillus in health and disease, a driver or just along for the ride. Curr Opin Biotechnol. 2018 Feb;49:140-147. doi: 10.1016/j.copbio.2017.08.004. Epub 2017 Sep 1.
4 The Impact of Lactobacillus plantarum on the Gut Microbiota of Mice with DSS-Induced Colitis. Biomed Res Int. 2019 Feb 20;2019:3921315. doi: 10.1155/2019/3921315. eCollection 2019.
5 Exopolysaccharide Produced by Lactobacillus Plantarum Induces Maturation of Dendritic Cells in BALB/c Mice.PLoS One. 2015 Nov 24;10(11):e0143743. doi: 10.1371/journal.pone.0143743. eCollection 2015.
6 Involvement of TLR4/ CXCL9/ PREX-2 pathway in the development of hepatocellular carcinoma (HCC) and the promising role of early administration of lactobacillus plantarum in Wistar rats.Tissue Cell. 2019 Oct;60:38-47. doi: 10.1016/j.tice.2019.07.010. Epub 2019 Jul 31.
7 Short communication: Complete genome sequence of Lactobacillus plantarum J26, a probiotic strain with immunomodulatory activity. J Dairy Sci. 2019 Dec;102(12):10838-10844. doi: 10.3168/jds.2019-16593. Epub 2019 Sep 20.
8 Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.Immunity. 2019 Feb 19;50(2):446-461.e9. doi: 10.1016/j.immuni.2018.12.020. Epub 2019 Jan 29.
9 Beneficial bacteria activate type-I interferon production via the intracellular cytosolic sensors STING and MAVS. Gut Microbes. 2020 Jul 3;11(4):771-788. doi: 10.1080/19490976.2019.1707015. Epub 2020 Jan 15.
10 Human Gut-Associated Natural Killer Cells in Health and Disease.Front Immunol. 2019 May 3;10:961. doi: 10.3389/fimmu.2019.00961. eCollection 2019.
11 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.
12 Probiotics importance and their immunomodulatory properties. J Cell Physiol. 2019 Jun;234(6):8008-8018. doi: 10.1002/jcp.27559. Epub 2018 Oct 14.

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