Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0104)
HIF Name
High affinity immunoglobulin gamma Fc receptor I
HIF Synonym(s)
Fc fragment of IgG receptor Ia, FCGR1A, FCRI, CD64A, IGFR1
HIF Classification
Fc Receptor (FCR)
Molecular Function
IgG-binding protein; Receptor
Description FcgR1 also known as CD64, is a subtype of Fc Receptor. [1]
Pfam Immunoglobulin domain (PF00047 )
Immunoglobulin domain (PF13895 )
Pathway Acute myeloid leukemia (hsa05221 )
Fc gamma R-mediated phagocytosis (hsa04666 )
Hematopoietic cell lineage (hsa04640 )
Leishmaniasis (hsa05140 )
Osteoclast differentiation (hsa04380 )
Phagosome (hsa04145 )
Staphylococcus aureus infection (hsa05150 )
Systemic lupus erythematosus (hsa05322 )
Transcriptional misregulation in cancer (hsa05202 )
Tuberculosis (hsa05152 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
FCGR1_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Citrobacter rodentium (enterobacteria) MIC00366
             Description Indeed, in mice, IgG and activating FcgRs are protective against the systemic spread of Citrobacter rodentium, an enteropathic bacteria. [2]
         Lactobacillus plantarum (firmicutes) MIC00730
             Description Only monocytes exposed to IFN-I-producing Lactobacillus plantarum showed a very significant reduction in CD64 expression. [3]
         Pediococcus pentosaceus (firmicutes) MIC01430
             Description Only monocytes exposed to IFN-I-producing Pediococcus pentosaceus showed a very significant reduction in CD64 expression. [3]
References
1 A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.J Hematol Oncol. 2013 Jan 4;6:1. doi: 10.1186/1756-8722-6-1.
2 Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019 Apr 16;50(4):1099-1114.e10. doi: 10.1016/j.immuni.2019.02.006. Epub 2019 Mar 12.
3 Beneficial bacteria activate type-I interferon production via the intracellular cytosolic sensors STING and MAVS. Gut Microbes. 2020 Jul 3;11(4):771-788. doi: 10.1080/19490976.2019.1707015. Epub 2020 Jan 15.

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