Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0093)
HIF Name
HLA class II histocompatibility antigen, DR alpha chain
HIF Synonym(s)
MHC II, HLA-DRA1, HLA-DRA
HIF Classification
Checkpoint molecule (CM)
Description The HLA-DRA is reported to be immune associated genes. [1]
Pfam Class II histocompatibility antigen, alpha domain (PF00993 )
Immunoglobulin C1-set domain (PF07654 )
Pathway Allograft rejection (hsa05330 )
Antigen processing and presentation (hsa04612 )
Asthma (hsa05310 )
Autoimmune thyroid disease (hsa05320 )
Cell adhesion molecules (CAMs) (hsa04514 )
Epstein-Barr virus infection (hsa05169 )
Graft-versus-host disease (hsa05332 )
Hematopoietic cell lineage (hsa04640 )
Herpes simplex virus 1 infection (hsa05168 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Inflammatory bowel disease (IBD) (hsa05321 )
Influenza A (hsa05164 )
Intestinal immune network for IgA production (hsa04672 )
Leishmaniasis (hsa05140 )
Phagosome (hsa04145 )
Rheumatoid arthritis (hsa05323 )
Staphylococcus aureus infection (hsa05150 )
Systemic lupus erythematosus (hsa05322 )
Th1 and Th2 cell differentiation (hsa04658 )
Th17 cell differentiation (hsa04659 )
Toxoplasmosis (hsa05145 )
Tuberculosis (hsa05152 )
Type I diabetes mellitus (hsa04940 )
Viral myocarditis (hsa05416 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
DRA_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Lactobacillus plantarum (firmicutes) MIC00730
             Description The Lactobacillus plantarum exopolysaccharide also up-regulated the expression of MHC II and CD86 on DCs surface and promoted T cells to proliferate in vitro. [2]
References
1 Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma.Nat Commun. 2019 Jun 11;10(1):2541. doi: 10.1038/s41467-019-10493-6.
2 Exopolysaccharide Produced by Lactobacillus Plantarum Induces Maturation of Dendritic Cells in BALB/c Mice.PLoS One. 2015 Nov 24;10(11):e0143743. doi: 10.1371/journal.pone.0143743. eCollection 2015.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.