Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0055)
HIF Name
T-lymphocyte activation antigen CD86
HIF Synonym(s)
B7-2, ETC-1, CD86
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Host cell receptor for virus entry; Receptor
Description CD86 is expressed on T cells to regulate responses to self-proteins. [1]
Pfam Immunoglobulin V-set domain (PF07686 )
Immunoglobulin domain (PF13895 )
Pathway Allograft rejection (hsa05330 )
Autoimmune thyroid disease (hsa05320 )
Cell adhesion molecules (CAMs) (hsa04514 )
Graft-versus-host disease (hsa05332 )
Intestinal immune network for IgA production (hsa04672 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Rheumatoid arthritis (hsa05323 )
Systemic lupus erythematosus (hsa05322 )
Toll-like receptor signaling pathway (hsa04620 )
Transcriptional misregulation in cancer (hsa05202 )
Type I diabetes mellitus (hsa04940 )
Viral myocarditis (hsa05416 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CD86_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bacteroides sp. (CFB bacteria) MIC00176
             Description The proportions of cells expressing the co-receptors CD86 was associated with the abundance of Bacteroidales. [2]
         Lactobacillus plantarum (firmicutes) MIC00730
             Description The proportions of cells expressing the co-receptors CD86 was associated with the abundance of Lactobacillus plantarum. [2]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with CD86 expression. [3]
         Methanobrevibacter smithii (euryarchaeotes) MIC00792
             Description The cell-surface receptors CD86 was associated with the abundance of Methoanobrevibacter smithii. [4]
         Rikenella microfusus (CFB bacteria) MIC01112
             Description The proportions of cells expressing the co-receptors CD86 was associated with Rikenellaceae. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Staphylococcus aureus inhibits T-cell IL-2 responses through modulation of CD86. [5]
References
1 Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2 Exopolysaccharide Produced by Lactobacillus Plantarum Induces Maturation of Dendritic Cells in BALB/c Mice.PLoS One. 2015 Nov 24;10(11):e0143743. doi: 10.1371/journal.pone.0143743. eCollection 2015.
3 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
4 The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells. PLoS One. 2014 Jun 10;9(6):e99411. doi: 10.1371/journal.pone.0099411. eCollection 2014.
5 Control of adaptive immune responses by Staphylococcus aureus through IL-10, PD-L1, and TLR2.Sci Rep. 2012;2:606. doi: 10.1038/srep00606. Epub 2012 Aug 28.

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