Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00792)
MIC Name Methanobrevibacter smithii (euryarchaeotes)
Body Site Gut
Lineage Kingdom: Archaea
Phylum: Euryarchaeota
Class: Methanobacteria
Order: Methanobacteriales
Family: Methanobacteriaceae
Genus: Methanobrevibacter
Species: Methanobrevibacter smithii
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Utilize carbon dioxide; Utilize hydrogen and formate as energy sources and acetate as carbon source
Gram Positive
Host Relationship Commensal
Genome Size (bp) 1853160
Description Methanobrevibacter smithii is a predominant archaeon in the human gut. Lower counts have been associated with obesity while higher amounts have been associated with anorexia. Methanobrevibacter smithii affects specificity and efficiency of bacterial digestion of dietary polysaccharides.
External Links Taxonomy ID
2173
Genome Assembly ID
ASM1652v1
GOLD Organism ID
Go0102218
Disease Relevance
          Anorexia nervosa  [ICD-11: 6B80]
             Description Anorexia nervosa intestinal microbiota was significantly affected at every taxonomic level, showing a significant increase of the archeon Methanobrevibacter smithii compared with healthy controls. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Methanobrevibacter smithii was not a strong inducer of the inflammatory response in inflammatory bowel disease. [2]
          Multiple sclerosis  [ICD-11: 8A40]
             Description Methanobrevibacter is upregulated in disease expression of Multiple sclerosis. [3]
          Obesity  [ICD-11: 5B81]
             Description Methanobrevibacter smithii is upregulated in disease expression of obesity. [4]
Host Genetic Factors (HGFs)
          rs6666120
             HGF ID HGF1950 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6666120 SNP was significantly associated with the relative abundance of Methanobrevibacter (p-value=1.23E-08). [5]
          rs651821
             HGF ID HGF1924 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The APOA5 rs651821 SNP increased the abundance of Methanobrevibacter. [6]
Host Immune Factors (HIFs)
          T-lymphocyte activation antigen CD86
             HIF ID HIFM0055 HIF Info       Class Checkpoint molecule (CM)
             Description The cell-surface receptors CD86 was associated with the abundance of Methoanobrevibacter smithii. [7]
          C-C chemokine receptor type 7
             HIF ID HIFM0036 HIF Info       Class Cytokine (Cyt)
             Description The expression of CD197 is important to Methanobrevibacter smithii. [7]
          Interferon-4
             HIF ID HIFM0149 HIF Info       Class Cytokine (Cyt)
             Description Methanobrevibacter smithii is associated with IL-4 expression. [8]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Methanobrevibacter smithii is associated with IFN-Gamma. [8]
          Monocyte-derived dendritic cells
             HIF ID HIFC0004 HIF Info       Class Dendritic cells (DCs)
             Description Methanobrevibacter smithii which is associated with monocyte-derived dendritic cells response. [7]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Methanobrevibacter smithii is associated with IgG immune response. [8]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Methanobrevibacter smithii archaeosomes-entrapped mzNL4-3 VLPs specifically induced and augmented T-helper type 1 cells oriented responses against HIV antigens. [8]
Environmental Factor(s)
             Disbiome ID
      234
             gutMDisorder ID
      gm0439
References
1 Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests. PLoS One. 2017 Jun 21;12(6):e0179739. doi: 10.1371/journal.pone.0179739. eCollection 2017.
2 Increased prevalence of Methanosphaera stadtmanae in inflammatory bowel diseases. PLoS One. 2014 Feb 3;9(2):e87734. doi: 10.1371/journal.pone.0087734. eCollection 2014.
3 Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017 Feb;20(2):145-155. doi: 10.1038/nn.4476. Epub 2017 Jan 16.
4 The impact of the gut microbiota on human health: an integrative view. Cell. 2012 Mar 16;148(6):1258-70. doi: 10.1016/j.cell.2012.01.035.
5 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
6 The effect of host genetics on the gut microbiome.Nat Genet. 2016 Nov;48(11):1407-1412. doi: 10.1038/ng.3663. Epub 2016 Oct 3.
7 The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells. PLoS One. 2014 Jun 10;9(6):e99411. doi: 10.1371/journal.pone.0099411. eCollection 2014.
8 Methanobrevibacter smithii archaeosomes-entrapped mzNL4-3 virus-like particles induce specific T helper 1-oriented cellular and humoral responses against HIV-1. Curr HIV Res. 2013 Sep;11(6):491-7. doi: 10.2174/1570162x11666131216125059.

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