Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0036)
HIF Name
C-C chemokine receptor type 7
HIF Synonym(s)
C-C motif chemokine receptor 7, BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
HIF Classification
Cytokine (Cyt)
Molecular Function
G-protein coupled receptor; Receptor; Transducer
Description By guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance. [1]
Pfam 7 transmembrane receptor (rhodopsin family) (PF00001 )
Pathway Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CCR7_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Methanobrevibacter smithii (euryarchaeotes) MIC00792
             Description The expression of CD197 is important to Methanobrevibacter smithii. [2]
         Methylorubrum extorquens (alpha-proteobacteria) MIC00814
             Description The chemokines CCR7 expression was associated with the Methylobacterium oryzae abundance. [3]
References
1 CCR7 and its ligands: balancing immunity and tolerance.Nat Rev Immunol. 2008 May;8(5):362-71. doi: 10.1038/nri2297.
2 The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells. PLoS One. 2014 Jun 10;9(6):e99411. doi: 10.1371/journal.pone.0099411. eCollection 2014.
3 Bacteria in the adventitia of cardiovascular disease patients with and without rheumatoid arthritis. PLoS One. 2014 May 29;9(5):e98627. doi: 10.1371/journal.pone.0098627. eCollection 2014.

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