Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00814)
MIC Name Methylorubrum extorquens (alpha-proteobacteria)
MIC Synonyms Bacillus extorquens
Body Site Ocular Surface
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Rhizobiales
Family: Methylobacteriaceae
Genus: Methylorubrum
Species: Methylorubrum extorquens
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Host Relationship Opportunistic pathogen
Description Methylobacterium extorquens also known as Bacillus extorquens, Vibrio extorquens, is an aerobic, Gram negative bacterium. It was positively related to hepatic encephalopathy within the peripheral blood and faeces.
External Links Taxonomy ID
408
Genome Assembly ID
ASM24343v2
GOLD Organism ID
Go0494001
Disease Relevance
          Chronic liver disease  [ICD-11: DB99]
             Description Methylobacterium extorquens was positively related to Hepatic encephalopathy. [1]
Host Genetic Factors (HGFs)
          rs7702475
             HGF ID HGF1391 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7702475 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=2.46E-07). [2]
          rs73041416
             HGF ID HGF1383 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs73041416 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=6.85E-06). [2]
          rs6857914
             HGF ID HGF2061 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6857914 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=3.21E-06). [2]
          rs67737950
             HGF ID HGF2064 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs67737950 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=2.73E-07). [2]
          rs4861117
             HGF ID HGF1681 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4861117 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=1.01E-05). [2]
          rs4842665
             HGF ID HGF2221 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs4842665 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=1.32E-05). [2]
          rs4693242
             HGF ID HGF1879 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4693242 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=9.14E-06). [2]
          rs35294573
             HGF ID HGF1303 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs35294573 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=6.73E-06). [2]
          rs308961
             HGF ID HGF1304 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs308961 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=8.12E-07). [2]
          rs2503218
             HGF ID HGF1429 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2503218 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=3.47E-06). [2]
          rs1454337
             HGF ID HGF1876 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1454337 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=7.10E-06). [2]
          rs13025486
             HGF ID HGF1921 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs13025486 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=5.92E-06). [2]
          rs1278260
             HGF ID HGF1948 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1278260 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=6.21E-07). [2]
          rs11244781
             HGF ID HGF1947 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11244781 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=4.49E-06). [2]
          rs10547084
             HGF ID HGF2065 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs10547084 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=4.93E-07). [2]
          rs10195682
             HGF ID HGF1922 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10195682 SNP in mucosal immunity pathways influences the abundance of Methylobacterium in the upper airway (p-value=6.08E-06). [2]
Host Immune Factors (HIFs)
          C-C chemokine receptor type 7
             HIF ID HIFM0036 HIF Info       Class Cytokine (Cyt)
             Description The chemokines CCR7 expression was associated with the Methylobacterium oryzae abundance. [3]
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description The gene encoding IL-1alpha was up-regulated during Methylobacterium infection. [3]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description The gene encoding IL-1beta was up-regulated during Methylobacterium infection. [3]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description The gene encoding IL-6 was up-regulated during Methylobacterium oryzae infection. [3]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description The gene encoding IL-8 was up-regulated during Methylobacterium oryzae infection. [3]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Methylobacterium was associated with TNF-Alpha. [3]
          Toll-like receptor
             HIF ID HIFM0001 HIF Info       Class Toll-like receptor (TLR)
             Description Methylobacterium oryzae was able to stimulate the activation of TLR2-mediated NFB signalling albeit at a lower level. [3]
References
1 Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy. Sci Rep. 2018 May 29;8(1):8210. doi: 10.1038/s41598-018-26509-y.
2 Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.Microbiome. 2017 Feb 1;5(1):16. doi: 10.1186/s40168-016-0227-5.
3 Bacteria in the adventitia of cardiovascular disease patients with and without rheumatoid arthritis. PLoS One. 2014 May 29;9(5):e98627. doi: 10.1371/journal.pone.0098627. eCollection 2014.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.