Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0001)
HIF Name
Toll-like receptor
HIF Synonym(s)
18-w, 18-wheeler, 18W, CG8896, CT25100, Dmel\CG8896, l(2)00053, toll, Toll-2, Toll2
HIF Classification
Toll-like receptor (TLR)
Molecular Function
Receptor
Description Toll-like receptor. Toll-like receptors ( TLRs) are a class of proteins that play a key role in the innate immune system. [1]
Pfam Leucine rich repeat C-terminal domain (PF01463 )
Leucine rich repeat (PF13855 )
TIR domain (PF01582 )
Pathway Amoebiasis (hsa05146 )
Chagas disease (American trypanosomiasis) (hsa05142 )
Epstein-Barr virus infection (hsa05169 )
Hepatitis B (hsa05161 )
Herpes simplex virus 1 infection (hsa05168 )
Human immunodeficiency virus 1 infection (hsa05170 )
Inflammatory bowel disease (IBD) (hsa05321 )
Legionellosis (hsa05134 )
Leishmaniasis (hsa05140 )
Malaria (hsa05144 )
Measles (hsa05162 )
PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
PI3K-Akt signaling pathway (hsa04151 )
Phagosome (hsa04145 )
Proteoglycans in cancer (hsa05205 )
Rheumatoid arthritis (hsa05323 )
Salmonella infection (hsa05132 )
Toll-like receptor signaling pathway (hsa04620 )
Toxoplasmosis (hsa05145 )
Tuberculosis (hsa05152 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
A0A0S2Z4S4_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Faecalibacterium prausnitzii (firmicutes) MIC00590
             Description Faecalibacterium prausnitzii is associated with the activation of TLR system. [2]
         Leptospira borgpetersenii (spirochaetes) MIC00758
             Description Toll-like receptors were involved in the protection against pathogenic Leptospira antigens. [3]
         Methylorubrum extorquens (alpha-proteobacteria) MIC00814
             Description Methylobacterium oryzae was able to stimulate the activation of TLR2-mediated NFB signalling albeit at a lower level. [4]
         Neisseria sp. (beta-proteobacteria) MIC00900
             Description TLR recognition of the Neisseria-associated molecular patterns (NAMPs) plays a critical role in host innate. [5]
         Shigella boydii (enterobacteria) MIC01180
             Description Shigella was associated with activation of TLR system. [6]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Staphylococcus aureus was associated with activation of TLR system. [7]
References
1 TLR signaling in B-cell development and activation.Cell Mol Immunol. 2013 Mar;10(2):103-6. doi: 10.1038/cmi.2012.61. Epub 2012 Dec 17.
2 Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients. Front Microbiol. 2018 Jul 2;9:1451. doi: 10.3389/fmicb.2018.01451. eCollection 2018.
3 Leptospira and inflammation. Mediators Inflamm. 2012;2012:317950. doi: 10.1155/2012/317950. Epub 2012 Oct 21.
4 Bacteria in the adventitia of cardiovascular disease patients with and without rheumatoid arthritis. PLoS One. 2014 May 29;9(5):e98627. doi: 10.1371/journal.pone.0098627. eCollection 2014.
5 The biology of Neisseria adhesins. Biology (Basel). 2013 Jul 29;2(3):1054-109. doi: 10.3390/biology2031054.
6 Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen-host interactions. Cell Microbiol. 2020 Apr;22(4):e13184. doi: 10.1111/cmi.13184.
7 Immune control of Staphylococcus aureus - regulation and counter-regulation of the adaptive immune response. Int J Med Microbiol. 2014 Mar;304(2):204-14. doi: 10.1016/j.ijmm.2013.11.008. Epub 2013 Dec 1.

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