Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00900)
MIC Name Neisseria sp. (beta-proteobacteria)
Body Site Nose
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Neisseriaceae
Genus: Neisseria
Species: Neisseria sp.
Oxygen Sensitivity Aerobe
Microbial Metabolism Oxidative
Gram Negative
Description Neisseria sp. is an aerobic, Gram negative species of genus Neisseria. It was isolates from a population of Neisseria which are clearly distinct from currently recognized species are tentatively designated at the species level.
External Links Taxonomy ID
192066
GOLD Organism ID
Go0005589
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Neisseria was significantly under-represented in autistic children. [1]
          Bacterial meningitis  [ICD-11: 1D01]
             Description Neisseriaceae can cause meningitis. [2]
          Infectious endocarditis  [ICD-11: BB40]
             Description Neisseriaceae can cause endocarditis. [2]
          Liver cirrhosis  [ICD-11: DB93]
             Description Neisseria sp. in the oropharyngeal microbiome was associated with liver cirrhosis. [3]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Neisseriaceae can cause gonorrhoea. [2]
          Pneumonia  [ICD-11: CA40]
             Description Neisseria sp. in the oropharyngeal microbiome was associated with liver pneumonia. [3]
          Sepsis  [ICD-11: 1G41]
             Description Neisseriaceae can cause septicaemia. [2]
Host Genetic Factors (HGFs)
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Oral microbiome Neisseriaceae differs between high AMY1-CN and low AMY1-CN groups at the OTU level (p-value<0.05). [4]
          rs11734372
             HGF ID HGF1680 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs11734372 SNP was significantly associated with the abundance of Neisseria (p-value=2.43E-06). [5]
          rs6867032
             HGF ID HGF1549 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6867032 SNP was significantly associated with the abundance of Neisseriaceae (p-value=4.60E-07). [6]
          rs4975794
             HGF ID HGF1548 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs4975794 SNP was significantly associated with the abundance of Neisseriaceae (p-value=4.60E-07). [6]
          rs34912554
             HGF ID HGF1230 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs34912554 SNP was significantly associated with the abundance of unclassified Neisseria (p-value<1.00E-08). [7]
          rs28719164
             HGF ID HGF2280 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs28719164 SNP was significantly associated with the abundance of unclassified Neisseria (p-value<1.00E-08). [7]
Host Immune Factors (HIFs)
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description Neisseria could interact with B cells. [8]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Purified recombinant PorA protein from Neisseria can activate monocyte-derived dendritic cells. [8]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description The Tfp of pathogenic Neisseria have been shown to mediate adhesion to the uropod of polarized neutrophils. [8]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Neisseriaceae is non-differing between SIgA-saliva and whole rumen. [9]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description The class A scavenger receptor on macrophages can enhance Neisseria uptake. [8]
          Monocytes
             HIF ID HIFC0024 HIF Info       Class Monocytes (Mono)
             Description Neisseria could activate TLR2-CD14 in monocytes. [8]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Neisseria could interact with T cells. [8]
          Toll-like receptor
             HIF ID HIFM0001 HIF Info       Class Toll-like receptor (TLR)
             Description TLR recognition of the Neisseria-associated molecular patterns (NAMPs) plays a critical role in host innate. [8]
Environmental Factor(s)
             Disbiome ID
      248
             gutMDisorder ID
      gm0466
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family. Nat Commun. 2015 Dec 16;6:10172. doi: 10.1038/ncomms10172.
3 Alterations of Bacteroides sp., Neisseria sp., Actinomyces sp., and Streptococcus sp. populations in the oropharyngeal microbiome are associated with liver cirrhosis and pneumonia. BMC Infect Dis. 2015 Jun 23;15:239. doi: 10.1186/s12879-015-0977-x.
4 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
5 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
6 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
7 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
8 The biology of Neisseria adhesins. Biology (Basel). 2013 Jul 29;2(3):1054-109. doi: 10.3390/biology2031054.
9 Host Immune Selection of Rumen Bacteria through Salivary Secretory IgA. Front Microbiol. 2017 May 12;8:848. doi: 10.3389/fmicb.2017.00848. eCollection 2017.

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