General Information of MIC (ID: MIC01180)
MIC Name	Shigella boydii (enterobacteria)
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Shigella Species: Shigella boydii
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Fermentative; Catalytic
Gram	Negative
Host Relationship	Pathogen
Genome Size (bp)	4574246
No. of Coding Genes	4485
No. of Non-Coding Genes	122
No. of Small Non-Coding Genes	122
No. of Gene Transcripts	4607
No. of Base Pairs	4574246
Description	Shigella boydii is a facultative anaerobic, Gram-negative bacterium of the genus Shigella. Like other members of the genus, S. boydii is a nonmotile, nonsporeforming, rod-shaped bacterium which can cause dysentery in humans through fecal-oral contamination.
External Links	Taxonomy ID	621
	Genome Assembly ID	ASM102722v1
	GOLD Organism ID	Go0520625
Disease Relevance
Irritable bowel syndrome  [ICD-11: DD91]
Description	Infectious diarrhoea was caused by Shigella in humans.				[1]
Shigella intestinal infection  [ICD-11: 1A02]
Description	Shigella boydii can cause bacillary dysentery.				[2]

Host Immune Factors (HIFs)
Cathelicidin antimicrobial peptide
HIF ID	HIFM0014	HIF Info	Class	Antimicrobial peptide (AMP)
Description	Shigella was found to switch-off the LL-37 expression.				[3]
C-X-C motif chemokine 2
HIF ID	HIFM0069	HIF Info	Class	Cytokine (Cyt)
Description	The expression of CXCL2 was found to positively correlate with the pro-inflammatory bacteria Shigella.				[4]
Toll-like receptor
HIF ID	HIFM0001	HIF Info	Class	Toll-like receptor (TLR)
Description	Shigella was associated with activation of TLR system.				[5]

Environmental Factor(s)
Disbiome ID			74
gutMDisorder ID			gm0602

References
1	Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota. BMC Gastroenterol. 2010 Nov 12;10:134. doi: 10.1186/1471-230X-10-134.
2	Distribution and characterization of Shiga toxin converting temperate phages carried by Shigella flexneri in Hispaniola. Infect Genet Evol. 2018 Nov;65:321-328. doi: 10.1016/j.meegid.2018.07.038. Epub 2018 Jul 31.
3	The human cathelicidin hCAP18/LL-37: a multifunctional peptide involved in mycobacterial infections.Peptides. 2010 Sep;31(9):1791-8. doi: 10.1016/j.peptides.2010.06.016. Epub 2010 Jun 25.
4	The role of gut microbiota in pathogenesis of Alzheimer's disease.J Appl Microbiol. 2019 Oct;127(4):954-967. doi: 10.1111/jam.14264. Epub 2019 Apr 15.
5	Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen-host interactions. Cell Microbiol. 2020 Apr;22(4):e13184. doi: 10.1111/cmi.13184.

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