Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0069)
HIF Name
C-X-C motif chemokine 2
HIF Synonym(s)
C-X-C motif chemokine ligand 2, CXCL2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description Stroma-derived factor 1 (SDF-1) (also known as CXCL2) is a cell-signaling cytokine and a chemoattractant. It is the only known ligand for CXCR4 and CXCR7. Using conditional mice, Chen and colleagues 102 induced SDF-1 disruption on PN7. At PN14, there were enlarged alveolar spaces. [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway Amoebiasis (hsa05146 )
Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
Epithelial cell signaling in Helicobacter pylori infection (hsa05120 )
IL-17 signaling pathway (hsa04657 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Legionellosis (hsa05134 )
NF-kappa B signaling pathway (hsa04064 )
NOD-like receptor signaling pathway (hsa04621 )
Rheumatoid arthritis (hsa05323 )
TNF signaling pathway (hsa04668 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CXCL2_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Cyanobacteria (cyanobacteria) MIC00475
             Description At the phylum level, Cyanobacteria is associated with CXCL-2 expression. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description The expression of CXCL2 was found to positively correlate with the pro-inflammatory bacterium Escherichia coli. [3]
         Eubacterium rectale (firmicutes) MIC00578
             Description The expression of CXCL2 was found to negatively correlate with the presence anti-inflammatory bacteria Eubacterium rectale. [3]
         Prevotella bivia (CFB bacteria) MIC01007
             Description Prevotella bivia could induce higher levels exspression of CXCL2. [4]
         Shigella boydii (enterobacteria) MIC01180
             Description The expression of CXCL2 was found to positively correlate with the pro-inflammatory bacteria Shigella. [3]
References
1 Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma.BMB Rep. 2018 Dec;51(12):630-635. doi: 10.5483/BMBRep.2018.51.12.140.
2 Lipopolysaccharides from Microcystis Cyanobacteria-Dominated Water Bloom and from Laboratory Cultures Trigger Human Immune Innate Response. Toxins (Basel). 2019 Apr 11;11(4):218. doi: 10.3390/toxins11040218.
3 The role of gut microbiota in pathogenesis of Alzheimer's disease.J Appl Microbiol. 2019 Oct;127(4):954-967. doi: 10.1111/jam.14264. Epub 2019 Apr 15.
4 The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.

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