Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00578)
MIC Name Eubacterium rectale (firmicutes)
MIC Synonyms Bacteroides rectalis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: unclassified Lachnospiraceae
Species: Eubacterium rectale
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative; Convert acetate
Gram Positive
Host Relationship Commensal
Genome Size (bp) 3449685
No. of Coding Genes 2860
No. of Non-Coding Genes 59
No. of Small Non-Coding Genes 59
No. of Gene Transcripts 2919
No. of Base Pairs 3045135
Description Eubacterium rectale is one of the most prevalent human gut bacteria. Eubacterium rectale group appear to be particularly dependent on carbohydrate content of the diet.
External Links Taxonomy ID
39491
Genome Assembly ID
T1815
GOLD Organism ID
Go0001428
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Eubacterium rectale was highly associated with inflammatory bowel disease. [1]
          Obesity  [ICD-11: 5B81]
             Description Eubacterium rectale was associated with genetic variants in Obesity. [2]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Clostridia coccoides-Eubacterium rectale is downregulated in disease expression of type 2 diabetes. [3]
          Ulcerative colitis  [ICD-11: DD71]
             Description Eubacterium rectale is downregulated in Eubacterium rectale. [1]
Host Genetic Factors (HGFs)
          NOD2
             HGF ID HGF2335 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of NOD2 increased the abundance of Eubacterium rectale. (p-value<0.05). [4]
          C4B
             HGF ID HGF2348 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description The low C4B-CN has been significantly associated with the high abundance of Eubacterium rectale (p-value<0.05). [5]
Host Immune Factors (HIFs)
          C-X-C motif chemokine 2
             HIF ID HIFM0069 HIF Info       Class Cytokine (Cyt)
             Description The expression of CXCL2 was found to negatively correlate with the presence anti-inflammatory bacteria Eubacterium rectale. [6]
          Immunoglobulin E
             HIF ID HIFM0271 HIF Info       Class Immunoglobulin (Ig)
             Description IgE immune responses was associated with Eubacterium rectale. [7]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Eubacterium rectale is associated with CD4+ T-cells responses. [8]
          CD25+ T cells
             HIF ID HIFC0063 HIF Info       Class T cells (TCs)
             Description Eubacterium rectale is associated with CD25+ T-cells responses. [8]
          Monocyte differentiation antigen CD14
             HIF ID HIFM0037 HIF Info       Class T-cell receptor (TCR)
             Description Microbiota composition improved significantly decreased Eubacterium rectale cluster and a reduction of soluble CD14 (sCD14). [8]
Environmental Factor(s)
             Disbiome ID
      8
References
1 Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention. Front Immunol. 2017 Nov 28;8:1674. doi: 10.3389/fimmu.2017.01674. eCollection 2017.
2 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
3 The impact of the gut microbiota on human health: an integrative view. Cell. 2012 Mar 16;148(6):1258-70. doi: 10.1016/j.cell.2012.01.035.
4 Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction.Sci Rep. 2017 Apr 3;7(1):548. doi: 10.1038/s41598-017-00484-2.
5 C4B gene influences intestinal microbiota through complement activation in patients with paediatric-onset inflammatory bowel disease.Clin Exp Immunol. 2017 Dec;190(3):394-405. doi: 10.1111/cei.13040. Epub 2017 Sep 25.
6 The role of gut microbiota in pathogenesis of Alzheimer's disease.J Appl Microbiol. 2019 Oct;127(4):954-967. doi: 10.1111/jam.14264. Epub 2019 Apr 15.
7 A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants.Pediatr Res. 2018 Mar;83(3):677-686. doi: 10.1038/pr.2017.270. Epub 2017 Dec 6.
8 Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial. Mucosal Immunol. 2011 Sep;4(5):554-63. doi: 10.1038/mi.2011.15. Epub 2011 Apr 27.

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